Efnine 13.9% Cream 20gm (eflornithine hydrochloride) is a prescription topical cream used to slow unwanted facial hair growth in women. It is commonly used to manage facial hirsutism, which may be associated with hormonal conditions such as polycystic ovary syndrome (PCOS). It is applied directly to the skin and helps reduce the rate of new hair growth with regular use, but it does not remove existing hair.
Written by: Syed Jommy Abbas, B. Pharma
Reviewed by: Dr. Devika Rani, MBBS
Last updated on: 05-06-2026
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Efnine 13.9% Cream 20gm (eflornithine hydrochloride) is a prescription topical cream used to slow unwanted facial hair growth in women. It is commonly used to manage facial hirsutism, which may be associated with hormonal conditions such as polycystic ovary syndrome (PCOS). It is applied directly to the skin and helps reduce the rate of new hair growth with regular use, but it does not remove existing hair.
Efnine 13.9% Cream 20gm (eflornithine hydrochloride) is a prescription topical medicine used to slow the growth of unwanted facial hair in women. It is commonly used for facial hirsutism, which may occur due to hormonal conditions such as polycystic ovary syndrome (PCOS) or other endocrine-related causes.
It works by inhibiting an enzyme called ornithine decarboxylase in the hair follicle. This enzyme plays a role in hair cell growth and division. By reducing its activity, Efnine 13.9% Cream 20gm slows the rate of new hair growth, which may make hair appear finer and less noticeable over time.
Efnine 13.9% Cream 20gm is applied directly to the affected areas of the face as directed by a doctor. Results are gradual and may take several weeks of consistent use. If treatment is stopped, the effect on slowing hair growth is no longer maintained, and facial hair growth gradually returns to its previous pattern over time.
Efnine 13.9% Cream 20gm is generally used as part of a supportive approach to managing hirsutism. It should be used under medical supervision, especially in cases where excess hair growth is linked to underlying hormonal or endocrine conditions that may require additional evaluation or treatment.
Efnine 13.9% Cream 20gm may be indicated by your doctor for:
Management and reduction of excessive or unwanted facial hair growth in women.
Slowing the rate of coarse hair development caused by polycystic ovary syndrome.
Treatment of unwanted facial hair where the underlying cause is unknown.
Efnine 13.9% Cream 20gm may provide benefits such as:
Efnine 13.9% Cream 20gm is used to slow unwanted hair growth, particularly on the face. It helps reduce the rate at which new hair grows, although it does not remove existing hair permanently.
Eflornithine works by blocking an enzyme called ornithine decarboxylase, which is involved in the production of substances needed for cell growth and hair follicle activity. By reducing the activity of this enzyme, the medicine slows the growth and division of cells within the hair follicle.
As hair growth becomes slower, hair may appear finer and less noticeable over time. The effect develops gradually and usually requires continued use to maintain results.
By slowing hair follicle activity rather than removing hair directly, Efnine 13.9% Cream 20gm is often used alongside other hair removal methods such as shaving, threading, or laser treatments.
If you miss a dose of Efnine 13.9% Cream 20gm, simply apply it as soon as you remember. If it is almost time for your next scheduled application, skip the missed dose and return to your regular routine. Do not apply extra cream to make up for a forgotten dose, as this may increase the risk of skin irritation.
Therapeutic Class
Dermatological / Antihirsutism
Action Class
Enzyme Inhibitor (ODC Inhibitor)
Chemical Class
Amino Acid Analogue
Habit Forming
No
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