Vostazole 100mg/200mg Tablet

Vostazole 100mg 200mg Tablet contains Furazolidone and Metronidazole, a combination of two antimicrobial agents used in the treatment of gastrointestinal infections caused by susceptible bacteria and protozoa. Furazolidone is a nitrofuran derivative with antibacterial and antiprotozoal activity, while Metronidazole is a nitroimidazole antimicrobial effective against anaerobic bacteria and protozoal organisms. Together, they help control infective diarrhoea, intestinal infections, and mixed gastrointestinal infections by targeting a broad range of causative organisms. This combination is commonly prescribed in selected intestinal infections under medical supervision and should be used exactly as directed by your doctor.

Vostazole 100mg 200mg Tablet combines Furazolidone, a nitrofuran antimicrobial, with Metronidazole, a nitroimidazole antimicrobial, to provide broad antimicrobial coverage against susceptible intestinal pathogens including bacteria and protozoa.

Furazolidone works by interfering with bacterial enzyme systems involved in carbohydrate metabolism and nucleic acid synthesis. It exhibits activity against certain Gram-positive and Gram-negative bacteria and also shows effectiveness against some protozoal organisms. It has historically been used in gastrointestinal infections where bacterial contamination and protozoal involvement coexist.

Metronidazole acts primarily against anaerobic bacteria and protozoa by entering susceptible microbial cells and undergoing intracellular reduction. This produces reactive intermediates that damage microbial DNA and inhibit nucleic acid synthesis, leading to microbial death. It is particularly effective against organisms such as Entamoeba histolytica, Giardia lamblia, and anaerobic bacteria commonly associated with intestinal infection.

The combination offers broader antimicrobial coverage than either agent alone and may be prescribed in selected gastrointestinal infections where mixed infective causes are suspected. It is generally used for short prescribed durations and should not be taken unnecessarily because inappropriate antimicrobial use may contribute to resistance.

The uses of Vostazole 100mg 200mg Tablet are as follows:

Infective Diarrhoea

Used in selected bacterial or protozoal diarrhoeal infections.

Amoebic Intestinal Infection

Helps control susceptible protozoal infections affecting the intestine.

Giardiasis

Used in selected cases involving Giardia infection.

Mixed Gastrointestinal Infections

Useful where bacterial and protozoal organisms may coexist.

Intestinal Dysentery

Helps control infective intestinal inflammation under medical supervision.

Here are the benefits of Vostazole 100mg 200mg Tablet:

• Broad antimicrobial coverage: Targets both bacteria and protozoa.

• Supports gastrointestinal infection control: Helps reduce infective symptoms in susceptible intestinal infections.

• Dual mechanism action: Two different antimicrobial pathways improve coverage.

• Useful in mixed infections: Beneficial when multiple organisms are involved.

• Helps reduce intestinal pathogen load: Supports clinical recovery when used appropriately.

Like all medicines, Vostazole 100mg 200mg Tablet may cause side effects in some individuals, especially during treatment initiation.

Common Side Effects:

• Nausea: Mild nausea may occur during treatment.

• Abdominal Discomfort: Mild stomach upset or cramps may occur.

• Metallic Taste: Common with Metronidazole.

• Loss of Appetite: Temporary reduction in appetite may occur.

• Headache: Mild headache may develop in some individuals.

Uncommon Side Effects:

• Dizziness: Mild dizziness may occur.

• Dry Mouth: Temporary dryness may be noticed.

• Dark Urine: Harmless darkening of urine may occur with Metronidazole.

Serious Side Effects (Require Immediate Medical Attention):

• Severe Allergic Reaction: Rash, swelling, or breathing difficulty requires urgent attention.

• Persistent Vomiting: Severe gastrointestinal intolerance needs medical review.

• Neurological Symptoms: Tingling, numbness, or coordination problems require immediate evaluation.

Always consult your doctor if symptoms worsen or unusual side effects appear.

To ensure safe and effective use:

• Take exactly as prescribed.

• Swallow with water.

• Usually taken after food to reduce stomach irritation.

• Complete the prescribed course.

• Do not stop early even if symptoms improve.

• Avoid alcohol during treatment.

Vostazole 100mg 200mg Tablet works through two complementary antimicrobial mechanisms.

Furazolidone interferes with bacterial enzyme systems involved in energy metabolism and nucleic acid function, inhibiting growth of susceptible bacteria and certain protozoa.

Metronidazole enters anaerobic bacteria and protozoal cells, where it is reduced to active metabolites that damage microbial DNA and inhibit nucleic acid synthesis, resulting in microbial death.

Together, this combination provides broader antimicrobial action against susceptible intestinal pathogens.

• Complete the full course.

• Avoid alcohol completely.

• Maintain hydration during diarrhoea.

• Do not self-medicate repeatedly.

• Seek medical review if diarrhoea persists.

• Store below 25°C

• Keep away from moisture

• Protect from direct sunlight

• Keep out of reach of children

Vostazole 100mg 200mg Tablet may be taken after food to improve gastric tolerance. However:

• Avoid alcohol completely: Metronidazole may cause flushing, nausea, vomiting, abdominal discomfort, and headache when taken with alcohol.

• Maintain adequate hydration: Fluid intake is important, especially if diarrhoea is present, to prevent dehydration.

• Prefer light meals: Bland food may improve gastric tolerance in individuals experiencing nausea or abdominal discomfort.

• Avoid fermented or alcohol-containing products: Certain syrups, tonics, or fermented foods may trigger alcohol-related reactions in sensitive individuals.

Vostazole 100mg 200mg Tablet may interact with:

• Alcohol-containing Preparations: Concurrent use may trigger a disulfiram-like reaction with nausea, flushing, and vomiting.

• Anticoagulants: Metronidazole may enhance anticoagulant effect and increase bleeding risk.

• Antiepileptic Medicines: These may alter Metronidazole metabolism and reduce treatment effectiveness.

• Lithium: Metronidazole may increase lithium levels and raise the risk of toxicity.

• Other Antimicrobial Medicines: Combined use may alter gut flora and increase gastrointestinal side effects.

• Monoamine Oxidase-Related Medicines: Furazolidone has weak MAO-inhibitory properties and may interact with certain medicines affecting neurotransmitter metabolism.

Vostazole 100mg 200mg Tablet should be used carefully in:

• Liver Disease: Metronidazole is primarily metabolised in the liver, and impaired liver function may increase drug exposure.

• Kidney Impairment: Caution is advised in significant renal dysfunction, especially during prolonged treatment.

• Peripheral Neuropathy: Metronidazole may worsen tingling, numbness, or nerve-related symptoms in susceptible individuals.

• Blood Disorders: Furazolidone should be used carefully in patients with pre-existing haematological abnormalities.

• Severe Gastrointestinal Disease: Persistent severe symptoms may require further clinical evaluation before treatment.

The dose depends on age, severity of infection, and clinical response. Always follow the prescribed schedule exactly.

If you miss a dose, take it when remembered unless the next dose is due soon. Do not double the dose.