Osonim P 100/500mg Tablet 10s

Osonim P 100 500mg Tablet 10s is a potent combination drug used for the symptomatic relief of moderate to severe pain and fever, often associated with inflammation. It contains two active ingredients: Nimesulide (100mg), which is a selective Non-Steroidal Anti-Inflammatory Drug (NSAID) known for its strong anti-inflammatory and pain-relieving effects, and Paracetamol (Acetaminophen 325mg), a well-known analgesic and antipyretic (fever reducer). The combination provides fast-acting and comprehensive relief by targeting both pain and the underlying inflammation. Due to the presence of Nimesulide, this medication is typically reserved for short-term use.

Osonim P 100 500mg Tablet 10s provides dual action against pain and inflammation by combining two effective agents:

Nimesulide (100mg): This is a selective COX-2 inhibitor, a type of NSAID. It works by blocking the production of pain and inflammation-causing chemicals (prostaglandins) at the site of injury.

Paracetamol / Acetaminophen (325mg): This component primarily acts in the brain to raise the pain threshold and reduce fever.

The combination is synergistic, meaning the effects of both drugs together are often greater than either drug alone. This makes Osonim P 100 500mg Tablet 10s highly effective for acute, moderate pain where inflammation is a key factor.

Because of the potential for serious side effects, particularly affecting the liver (hepatotoxicity) and stomach, Osonim P 100 500mg Tablet 10s is not intended for chronic, long-term use. It is crucial to follow your doctor's instructions regarding both the dose frequency and the total duration of treatment.

Osonim P 100 500mg Tablet 10s is prescribed for the short-term relief of acute painful and inflammatory conditions in adults, such as:

• Musculoskeletal Pain: Pain associated with sprains, strains, tendonitis, and arthritis flare-ups.
• Post-Operative and Traumatic Pain: Pain following surgery or injury.
• Dental Pain: Pain, swelling, and inflammation after dental procedures.
• Dysmenorrhea: Painful menstrual periods.
• Fever: When accompanied by inflammation and pain.

• Dual-Action Pain Relief: Combines two distinct analgesic mechanisms for superior relief compared to either component alone.
• Anti-Inflammatory Power: Nimesulide effectively targets and reduces inflammation, addressing the root cause of many types of pain.
• Fast Onset: The combination allows for a rapid onset of pain-relieving and fever-reducing effects.
• Comprehensive Symptom Control: Effectively manages pain, inflammation, and fever simultaneously.

Side effects are generally mild, but the risk of severe effects (especially on the liver and stomach) requires vigilance. Common Side Effects:

• Nausea, vomiting
• Diarrhoea, stomach pain
• Dizziness, drowsiness
• Heartburn (Dyspepsia) Serious Side Effects (Seek immediate medical attention if you experience):
• Liver Toxicity (Hepatotoxicity): Loss of appetite, severe abdominal pain, dark urine, or yellowing of the skin or eyes (jaundice). This is the most serious risk, especially with Nimesulide and Paracetamol overdose.
• Gastrointestinal Bleeding: Black, tarry stools, or vomiting blood (due to the NSAID component, Nimesulide).
• Kidney Problems: Reduced or absent urination, swelling of the hands or feet.
• Severe Allergic Reactions: Rash, hives, swelling of the face/throat, difficulty breathing (signs of Stevens-Johnson Syndrome or anaphylaxis).

Always take Osonim P 100 500mg Tablet 10s exactly as prescribed by your doctor.

• Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
• Take the medicine after a meal or snack to minimise the risk of stomach upset, which is common with NSAIDs like Nimesulide.
• The typical dose is one tablet, taken twice daily (12 hours apart).
• Crucial Rule: This medication is for short-term use only (usually no more than 5-10 days) to minimise the risk of liver damage.
• Do not exceed the prescribed dose or combine with any other medication containing Paracetamol or Nimesulide.

• Strictly Short-Term: Never use this medication for more than 10-15 days or for chronic pain management without explicit, ongoing instruction from a specialist due to the liver risks.
• Alcohol Warning: The most severe interaction is with alcohol. Do not consume alcohol while taking this medicine.
• Monitor Liver Symptoms: Be acutely aware of the symptoms of liver toxicity (jaundice, dark urine, severe stomach pain) and stop the medication and call your doctor immediately if they appear.
• Stomach Protection: Take this tablet with food to protect your stomach lining. If you have a history of ulcers, your doctor may prescribe a stomach protector (like a PPI) alongside it.
• Avoid Other Painkillers: Do not take any other drug containing Paracetamol or Nimesulide, and check with your doctor before combining with other NSAIDs (like ibuprofen).

• Store the tablets at room temperature, below 30°C, in a cool, dry place.
• Keep the medicine away from excessive moisture and direct sunlight.
• Keep the tablets out of the reach of children and pets.
• Do not use the medication past the expiry date printed on the packaging.

Food: Taking the tablet with food helps reduce the risk of gastrointestinal upset associated with Nimesulide. Food does not significantly reduce the drug's effectiveness.

Osonim P 100 500mg Tablet 10s may interact with several other medicines, especially those affecting the liver, blood, or stomach. Always inform your doctor about all medications you are taking.

• Blood Thinners (e.g., Warfarin): May increase the risk of bleeding. Regular monitoring of INR (a blood clotting test) is advised.
• Other Painkillers (NSAIDs like Ibuprofen or Aspirin): Can raise the risk of stomach ulcers, bleeding, or kidney strain when used together.
• Liver-affecting Medicines (e.g., Rifampicin, Phenytoin): May increase liver toxicity. Use with caution and under medical supervision.
• Methotrexate: May raise methotrexate levels in the blood, increasing the risk of harmful side effects.
• Diuretics (water pills): Nimesulide may reduce their effectiveness, especially in people with heart or kidney conditions.
• Other Paracetamol-containing Products: Avoid combining to prevent accidental overdose and liver damage.
• Alcohol: Strictly avoid. Alcohol increases the risk of severe liver injury when taken with Paracetamol and Nimesulide.

Patients with certain pre-existing conditions need extreme caution:

• Severe Liver Disease (Contraindicated): Due to the high risk of hepatotoxicity from both Nimesulide and Paracetamol, this medication is strictly contraindicated (should not be used) in patients with active or severe liver impairment.
• Gastrointestinal Bleeding/Ulcers (Contraindicated): Nimesulide can worsen or reactivate peptic ulcers or cause stomach bleeding.
• Severe Kidney Disease: Both components are primarily cleared by the kidneys. Severe renal impairment requires dose reduction or avoidance.
• Heart Failure/High Blood Pressure: NSAIDs like Nimesulide can cause fluid retention, worsening heart failure and raising blood pressure.

The standard dose of Osonim P 100 500mg Tablet 10s is one tablet (Nimesulide 100mg + Paracetamol 325mg) taken twice daily (every 12 hours).

• The medication should be used for the shortest possible duration.
• NEVER exceed 2 tablets in 24 hours to prevent serious side effects from Nimesulide and Paracetamol. Always adhere to the dosing schedule prescribed by your doctor.

An overdose of Osonim P 100 500mg Tablet 10s, which contains Nimesulide and Paracetamol, is a medical emergency and can lead to serious health complications. Immediate medical attention is essential, even if no symptoms are present initially.

Paracetamol overdose can cause severe liver damage. Early symptoms may include nausea, vomiting, loss of appetite, and abdominal pain. These signs often appear within the first 24 to 48 hours but may be mild or absent, making the condition harder to detect without medical tests.

As the overdose progresses, more serious symptoms may develop, such as yellowing of the skin or eyes (jaundice), dark urine, confusion, or extreme tiredness. These may indicate liver failure, which can be life-threatening if not treated promptly.

Nimesulide, on the other hand, can worsen liver toxicity and may also affect kidney function and the gastrointestinal system. Combining both drugs in excessive amounts increases the risk of multi-organ damage.

If you suspect an overdose of Osonim P 100 500mg Tablet 10s, do not wait for symptoms. Seek emergency care immediately. Early treatment, such as activated charcoal or antidotes like N-acetylcysteine (for Paracetamol), is most effective when started within hours of ingestion.

If you miss a dose of Osonim P 100 500mg Tablet 10s, take it as soon as you remember. If it is already close to the time for your next scheduled dose (e.g., within 4 hours), skip the missed dose and resume your regular dosing schedule. Do not take a double dose to catch up. Maintain the prescribed 12-hour gap between doses.