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Glimepiride + Metformin

Uses

How Glimepiride and Metformin Work Glimepiride and Metformin is a combination of two antidiabetic medications: Glimepiride and Metformin.

How it Works

Common side effects of Glimepiride and Metformin include nausea, diarrhea, headache, upper respiratory tract infection, dizziness, and flatulence.

Expert Advice

  • You have been prescribed this combination medicine as it can control blood sugar more effectively than metformin alone.
  • Continue to exercise regularly and maintain a healthy diet.
  • Take your other diabetes medications along with Glimepiride + Metformin.
  • Take this medication with food to reduce the risk of an upset stomach.
  • Regularly monitor your blood sugar levels while using this medicine.
  • Be aware that it can cause hypoglycemia (low blood sugar) when used with other antidiabetic medications, alcohol, or if you delay or miss a meal.
  • Inform your doctor about your diabetes treatment if you are scheduled for surgery under general anesthesia.
  • Notify your doctor immediately if you experience any of the following symptoms:
    • Deep or rapid breathing
    • Persistent nausea
    • Vomiting
    • Stomach pain
  • Glimepiride + Metformin may cause a rare but serious condition called lactic acidosis, which is characterized by an excess of lactic acid in the blood.
  • Your doctor may monitor your liver function regularly.
  • Inform your doctor if you develop symptoms such as:
    • Abdominal pain
    • Loss of appetite
    • Yellowing of the eyes or skin (jaundice)

Other Combinations

Glimepiride + Lobeglitazone Sulfate

Glimepiride + Metformin + Pioglitazone

Glimepiride + Metformin + Rosiglitazone

Glimepiride + Metformin + Sitagliptin

Glimepiride + Metformin + Vitamin B12 (Methylcobalamin)

Glimepiride + Metformin + Voglibose

Glimepiride + Pioglitazone

Glimepiride + Rosiglitazone

Atorvastatin + Glimepiride + Metformin

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Frequently asked questions

What is Glimepiride+Metformin?
Glimepiride+Metformin is a combination medication used to treat type 2 diabetes mellitus. It helps control blood glucose levels when combined with a healthy diet and regular exercise. Glimepiride stimulates insulin release from the pancreas, while Metformin reduces glucose production in the liver and enhances insulin sensitivity. This combination is not suitable for type 1 diabetes.
Can the use of Glimepiride+Metformin cause hypoglycemia?
Yes, Glimepiride+Metformin can cause hypoglycemia. Symptoms include nausea, headache, irritability, hunger, sweating, dizziness, rapid heartbeat, and anxiety. The risk increases if meals are missed, alcohol is consumed, excessive exercise occurs, or other antidiabetic medications are taken. Regular blood sugar monitoring is essential, and it is advisable to carry a quick source of sugar.
What are the possible side effects of Glimepiride+Metformin?
Common side effects of Glimepiride+Metformin include hypoglycemia, altered taste, nausea, stomach pain, diarrhea, headache, and upper respiratory infections. Serious but rare side effects include lactic acidosis, and long-term use may lead to Vitamin B12 deficiency.
Can the use of Glimepiride+Metformin lead to lactic acidosis?
Yes, Glimepiride+Metformin can cause lactic acidosis, a rare but serious condition resulting from high lactic acid levels in the blood. It is particularly dangerous for patients with kidney disease, the elderly, or those consuming excessive alcohol. Symptoms include muscle pain, dizziness, cold extremities, breathing difficulties, nausea, vomiting, stomach pain, and slow heart rate. Seek immediate medical attention if these symptoms occur.
Can the use of Glimepiride+Metformin lead to Vitamin B12 deficiency?
Yes, long-term use of Glimepiride+Metformin can result in Vitamin B12 deficiency due to impaired absorption. Untreated deficiency may lead to anemia and neurological issues, including tingling, numbness, weakness, urinary problems, cognitive changes, and balance difficulties. Annual Vitamin B12 supplementation is recommended to prevent these complications.
What are the recommended storage conditions for Glimepiride+Metformin?
Store Glimepiride+Metformin in its original container, tightly closed, and follow the storage instructions on the packaging. Dispose of any unused medicine properly to prevent accidental ingestion by pets or children.
Is it safe to take alcohol while I am also taking Glimepiride+Metformin?
No, consuming alcohol while taking Glimepiride+Metformin is unsafe as it can lower blood sugar levels and increase the risk of hypoglycemia and lactic acidosis.
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