Glimepiride + Metformin + Rosiglitazone

Uses

Glimepiride, Metformin, and Rosiglitazone are used in the treatment of type 2 diabetes mellitus.

How it Works

How Glimepiride, Metformin, and Rosiglitazone Work Glimepiride, Metformin, and Rosiglitazone is a combination of three antidiabetic medications: Glimepiride, Metformin, and Rosiglitazone. They work through different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea that increases the amount of insulin released by the pancreas to lower blood glucose levels. Metformin is a biguanide that reduces glucose production in the liver, delays glucose absorption from the intestines, and increases the body's sensitivity to insulin. Rosiglitazone is a thiazolidinedione that further enhances insulin sensitivity.

Side Effects

Common side effects of Glimepiride, Metformin, and Rosiglitazone include hypoglycemia (low blood glucose level), nausea, taste changes, diarrhea, stomach pain, headache, edema (swelling), weight gain, blurred vision, bone fractures, and respiratory tract infections.

Expert Advice

Take it with food to reduce the risk of an upset stomach.
It may cause hypoglycemia (low blood sugar levels) when used with other antidiabetic medications, alcohol, or if you delay or miss a meal.
Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms, such as:
- Cold sweats
- Cool, pale skin
- Tremors
- Anxiety
Your doctor may monitor your liver function regularly.
Inform your doctor if you develop symptoms such as:
- Abdominal pain
- Loss of appetite
- Yellowing of the eyes or skin (jaundice)