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Glimepiride + Metformin + Pioglitazone

Uses

How Glimepiride, Metformin, and Pioglitazone Work Glimepiride, Metformin, and Pioglitazone is a combination of three antidiabetic medications: Glimepiride, Metformin, and Pioglitazone. They work through different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea that increases the amount of insulin released by the pancreas to lower blood glucose levels. Metformin is a biguanide that reduces glucose production in the liver, delays glucose absorption from the intestines, and enhances the body's sensitivity to insulin. Pioglitazone is a thiazolidinedione that further increases insulin sensitivity.

How it Works

Common side effects of Glimepiride, Metformin, and Pioglitazone include hypoglycemia (low blood glucose level), nausea, diarrhea, headache, edema (swelling), anemia (low number of red blood cells), upper respiratory tract infection, dizziness, vomiting, flatulence, and bronchitis (inflammation of the airways).

Expert Advice

  • Take it with food to reduce the risk of an upset stomach.
  • It may cause hypoglycemia (low blood sugar levels) when used with other antidiabetic medications, alcohol, or if you delay or miss a meal.
  • Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms, which may include:
    • Cold sweats
    • Cool, pale skin
    • Tremors
    • Anxiety
  • Your doctor may monitor your liver function regularly.
  • Inform your doctor if you develop symptoms such as:
    • Abdominal pain
    • Loss of appetite
    • Yellowing of the eyes or skin (jaundice)

Other Combinations

Glimepiride + Lobeglitazone Sulfate

Glimepiride + Metformin + Rosiglitazone

Glimepiride + Metformin + Sitagliptin

Glimepiride + Metformin + Vitamin B12 (Methylcobalamin)

Glimepiride + Metformin + Voglibose

Glimepiride + Pioglitazone

Glimepiride + Rosiglitazone

Atorvastatin + Glimepiride + Metformin

Glimepiride + Metformin

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Frequently asked questions

Yes, this medication can cause hypoglycemia. Symptoms include nausea, headache, irritability, hunger, sweating, dizziness, rapid heartbeat, and anxiety. Hypoglycemia is more likely if meals are missed, alcohol is consumed, or if other antidiabetic medications are taken. Regular blood sugar monitoring is essential, and carrying a sugary item is recommended.
Yes, Glimepiride+Metformin+Pioglitazone can lead to Vitamin B12 deficiency due to the metformin it contains, which may interfere with Vitamin B12 absorption over time.
No, drinking alcohol while using Glimepiride+Metformin+Pioglitazone is unsafe as it can lower blood sugar levels and increase the risk of lactic acidosis.
Store the medicine in its original container, tightly closed, and follow the storage instructions on the label. Dispose of any unused medication properly to prevent accidental ingestion by pets or children.
Inform your doctor if you have congestive heart failure, kidney or liver issues, or swelling of the back of the eye. Additionally, disclose if you are pregnant, breastfeeding, or premenopausal, and list any medications, vitamins, or herbal supplements you are taking.
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