How Darunavir and Ritonavir work Darunavir and Ritonavir are a combination of two anti-HIV medications. Together, they interfere with an enzyme called protease, which is necessary for HIV-infected cells to produce new viruses. This action halts the production of new viruses, thereby treating HIV infections.
Common side effects of Darunavir and Ritonavir include diarrhea, headache, nausea, abdominal pain, rash, and vomiting.