Amitriptyline

Uses

Amitriptyline is used in the treatment of depression, anxiety, bed-wetting, migraine, obsessive-compulsive disorder, insomnia, and neuropathic pain.

How it Works

How Amitriptyline works Amitriptyline is a tricyclic antidepressant that possesses anticholinergic and sedative properties. It prevents the reuptake and subsequent inactivation of neurotransmitters called noradrenaline and serotonin, which are present at the nerve terminals in the brain. By inhibiting the reuptake of these monoamine neurotransmitters, Amitriptyline enhances their action in the brain. This mechanism is thought to be associated with its antidepressant effects and helps regulate mood. Additionally, it blocks the transmission of pain signals from nerves to the brain, thereby relieving neuropathic pain, which originates from damaged nerves.

Side Effects

Common side effects of Amitriptyline include constipation, dry mouth, orthostatic hypotension (sudden lowering of blood pressure upon standing), weight gain, aggressive behavior, nasal congestion (stuffy nose), sleepiness, dizziness, headache, decreased libido, nausea, fatigue, confusion, tremors, speech disorders, palpitations, changes in taste, paresthesia (tingling or pricking sensation), abnormalities of voluntary movements, loss of accommodation, atrioventricular block, micturition disorders, erectile dysfunction, abnormal ECG, and decreased sodium levels in the blood.

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