Amitriptyline + Pregabalin

Uses

Amitriptyline and Pregabalin are used in the treatment of neuropathic pain.

How it Works

How Amitriptyline and Pregabalin work Amitriptyline and Pregabalin is a combination of two medications: Amitriptyline and Pregabalin. Amitriptyline is a tricyclic antidepressant that increases the levels of chemical messengers (serotonin and noradrenaline) that inhibit the transmission of pain signals in the brain. Together, they alleviate neuropathic pain, which is pain resulting from damaged nerves. Pregabalin is an alpha-2 delta ligand that reduces pain by modulating the calcium channel activity of nerve cells.

Side Effects

Common side effects of Amitriptyline and Pregabalin include constipation, weight gain, sleepiness, dizziness, tiredness, blurred vision, dry mouth, increased heart rate, orthostatic hypotension (sudden drop in blood pressure upon standing), difficulty urinating, and uncoordinated body movements.

Other Combinations