T Ris Plus 2mg/2mg Tablet

Risperidone + Trihexyphenidyl is a combination medicine used to manage schizophrenia, psychosis, and related behavioural disturbances. Risperidone helps control hallucinations, delusions, aggression, and mood instability, while Trihexyphenidyl prevents movement-related side effects such as stiffness, tremors, and restlessness that may occur with antipsychotic therapy. This combination provides balanced symptom control while improving treatment tolerability and overall functioning. It is typically prescribed when antipsychotic therapy causes extrapyramidal symptoms (EPS).

Risperidone + Trihexyphenidyl is a prescription combination medicine commonly used in the treatment of schizophrenia, psychotic disorders, and certain behavioural disturbances. Risperidone belongs to the class of atypical antipsychotics that work by restoring chemical balance in the brain, particularly by blocking excessive dopamine (D2) and serotonin (5-HT2) activity. This helps reduce symptoms such as hallucinations, delusions, disorganised thinking, aggression, irritability, and severe mood fluctuations.

However, antipsychotic medicines like Risperidone may occasionally cause extrapyramidal symptoms (EPS), including tremors, muscle stiffness, rigidity, restlessness (akathisia), or involuntary movements. To counter this, the formulation includes Trihexyphenidyl, an anticholinergic agent that smoothens muscle control and helps prevent movement-related side effects. Trihexyphenidyl also improves patient comfort and treatment adherence, ensuring better long-term outcomes.

This combination is especially useful in patients who are sensitive to EPS or those who have previously developed movement-related side effects from antipsychotic therapy. With regular use, Risperidone + Trihexyphenidyl helps stabilise thoughts, emotions, and behaviour, enabling individuals to regain daily functioning and improve their quality of life.

The medicine should always be taken under strict medical supervision, as dosage adjustment depends on patient age, symptom severity, treatment response, and susceptibility to side effects. Consistent adherence is crucial because psychotic symptoms can return if treatment is interrupted. Patients should continue follow-ups with their doctor to monitor progress, manage side effects, and ensure safe long-term use.

• Treatment of schizophrenia
• Management of psychotic disorders and acute psychosis
• Control of hallucinations, delusions, disorganised thinking
• Reduction of aggression, irritability, and behavioural disturbances
• Prevention and management of extrapyramidal symptoms (EPS) caused by antipsychotics
• Useful in patients prone to tremors, stiffness, or drug-induced Parkinsonism
• Stabilisation of mood and improvement of daily functioning

1. Improves Symptoms of Schizophrenia and Psychosis

Risperidone helps reduce hallucinations, delusions, disorganised thinking, aggression, and severe mood disturbances, providing better emotional and behavioural stability.

2. Prevents and Reduces Extrapyramidal Side Effects (EPS)

Trihexyphenidyl is included to counteract movement-related side effects caused by Risperidone, such as stiffness, tremors, slowed movement, or muscle spasms.

3. Enhances Overall Treatment Tolerability

By combining an antipsychotic with an anticholinergic, this formulation ensures patients experience fewer motor side effects, improving comfort and adherence to long-term therapy.

4. Supports Better Daily Functioning

With reduced psychotic symptoms and controlled movement issues, patients are more able to manage daily activities, social interactions, and work responsibilities.

5. Helps Maintain Long-Term Stability

This combination is useful for patients likely to require ongoing treatment, helping prevent relapses, hospitalisations, and symptom flare-ups by providing balanced and sustained control.

Common side effects may include:

• Drowsiness or sedation
• Dry mouth
• Blurred vision
• Constipation
• Dizziness or light-headedness
• Weight gain
• Increased appetite
• Muscle stiffness (occasionally, despite Trihexyphenidyl)
• Restlessness or difficulty sitting still
• Tremors (rare)
• Changes in sleep patterns
• Low blood pressure on standing (orthostatic hypotension) Seek medical help if you experience severe EPS, confusion, palpitations, uncontrolled movements, high fever, or signs of neuroleptic malignant syndrome (rare).

• Take the tablet exactly as prescribed by your doctor.
• Swallow whole with water; do not crush or chew.
• Can be taken with or without food.
• Take at the same time each day for consistent therapeutic effect.
• Do not stop the medication abruptly unless advised by your doctor.
• Follow-up visits are important to adjust the dose and monitor side effects.

• Take the medicine at the same time daily for stable symptom control.
• Do not discontinue suddenly; symptoms may return or worsen.
• Inform your doctor if you notice restlessness, tremors, or unusual movements.
• Stay hydrated and maintain healthy lifestyle habits.
• Attend regular follow-ups for dose adjustments and monitoring of side effects.

• Store in a cool, dry place away from direct sunlight.
• Keep tablets in the original blister pack until use.
• Keep out of reach of children and pets.
• Do not use expired medicine or tablets with damaged packaging.

Risperidone + Trihexyphenidyl can be taken with or without food, but certain foods may influence side effects. High-fat meals may increase drowsiness due to slower digestion. Caffeine may worsen restlessness or insomnia in sensitive individuals. Alcohol must be strictly avoided due to increased sedation and risk of side effects.

Avoid:

• Alcohol

• Excess caffeine (coffee/energy drinks)

• Very high-fat meals if they worsen drowsiness

Some medicines can alter how this combination works or increase the risk of side effects. Always inform your doctor about all ongoing treatments.

Possible interactions with:

• CNS depressants (benzodiazepines, sleeping pills): Increase sedation

• Antihistamines: Enhance drowsiness and anticholinergic effects

• Antihypertensives: May increase risk of low blood pressure

• Anti-Parkinson’s drugs: May interfere with Trihexyphenidyl

• SSRIs (fluoxetine, paroxetine): Increase Risperidone levels

• Carbamazepine: may reduce Risperidone effectiveness

This combination should be used cautiously in patients with certain medical conditions, as antipsychotics and anticholinergics can worsen symptoms or complicate disease management. Caution in:

• Heart disease or irregular heartbeat
• Kidney or liver impairment
• Glaucoma (Trihexyphenidyl may increase eye pressure)
• Prostate enlargement or urinary retention
• Seizure disorders
• Severe dehydration
• Gastrointestinal obstruction
• Always discuss your medical history with your doctor before starting therapy.

The usual recommended dose is one tablet daily or as directed by your doctor. Dose may be adjusted based on clinical response, severity of symptoms, age, and tolerance. Do not change or stop the dose without medical guidance.

Overdose may cause severe drowsiness, low blood pressure, agitation, tremors, irregular heartbeat, seizures, or breathing difficulty. Trihexyphenidyl overdose may cause confusion, hallucinations, or high fever. Seek immediate medical attention. Supportive care, monitoring, and hospital treatment may be required.

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed tablet and continue with your regular schedule. Do not take two doses at the same time to compensate. Irregular dosing can worsen symptoms or cause relapse, so consider using reminders or pill organisers to maintain consistency.