Sirolimus

Uses

Sirolimus is used for the prevention of kidney transplant rejection.

How it Works

How Sirolimus works Sirolimus is an immunosuppressant that functions by suppressing the body’s immune response after the transplantation of an organ (e.g., liver, kidney, heart). This mechanism helps the body accept the new organ as if it were its own.

Side Effects

Common side effects of Sirolimus include decreased white blood cell count (neutrophils), stomatitis (inflammation of the mouth), sepsis, kidney infection, cytomegalovirus infection, herpes zoster, non-melanoma skin cancer, hemolytic uremic syndrome, hypersensitivity, pericardial effusion, venous thrombosis, pulmonary embolism, pneumonitis, pleural effusion, nosebleeds, pancreatic inflammation, ascites (accumulation of fluid in the abdominal cavity), osteonecrosis (reduced blood flow to the bones), and ovarian cysts.

Expert Advice

You may be frequently monitored for renal function during concomitant administration of sirolimus and ciclosporin.
Sirolimus increases the risk of infection and the development of certain types of cancer (e.g., lymphoma, skin cancer).
Seek immediate medical attention if you notice signs of infection, such as:
- Persistent sore throat
- Chills
- Fever
Report any changes in the appearance or size of a mole, night sweats, unusual growths or lumps, or unusual tiredness or weakness.
Avoid the use of live vaccines during treatment, as vaccinations may be less effective while taking sirolimus.
Use effective methods of contraception during sirolimus therapy and for 12 weeks after discontinuation of sirolimus.
Consult your doctor if you develop any of the following conditions:
- Liver problems
- Kidney problems
- High cholesterol or triglycerides
- Low blood platelet levels
- Diabetes or high blood sugar
- Lung or breathing problems
- High risk for rejection, especially if you have had a previous transplant that was lost to rejection
Limit exposure to sunlight and UV light by covering your skin with clothing and using a sunscreen with a high protection factor due to the increased risk of skin cancer when receiving sirolimus.
Take sirolimus at the same time in relation to ciclosporin, and consistently with or without food, as its blood levels will be monitored.

Other Combinations

Temsirolimus

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