Enizahex 25 Tablet

Enizahex 25 Tablet contains Tetrabenazine, a medication used to treat chorea (involuntary, jerky, or irregular movements) associated with Huntington’s disease. It belongs to a group of medicines known as monoamine depleters. By regulating the amount of certain natural substances in the brain that control muscle movement, Enizahex 25 Tablet helps reduce the frequency and severity of involuntary movements, allowing for better physical coordination and daily functioning.

Enizahex 25 Tablet is a prescription medication used to manage hyperkinetic movement disorders. It is primarily used for the symptoms of Huntington’s Disease, a neurological condition characterized by the progressive loss of motor control. Chorea, the most visible symptom, involves abrupt, purposeless movements caused by an oversensitivity or overabundance of dopamine in the brain's motor centers.

Tetrabenazine acts as a high-affinity, reversible inhibitor of the vesicular monoamine transporter 2 (VMAT2). In simple terms, it prevents the storage of neurotransmitters (primarily dopamine, but also serotonin and norepinephrine) within the vesicles of nerve cells. When these chemicals are not stored, they are broken down, leading to a depletion of dopamine at the nerve endings. This reduction in dopamine signaling "quiets" the overactive motor pathways in the brain that trigger involuntary jerking.

Enizahex 25 Tablet is extensively metabolized in the liver into its active metabolites (alpha- and beta-dihydrotetrabenazine). Due to its potent effect on brain chemistry, the dose is typically started very low and increased slowly to find the optimal balance between movement control and side effects.

Chorea associated with Huntington’s Disease

Reduction of involuntary, dance-like movements.

Tardive Dyskinesia

In some cases, used off-label to manage repetitive movements caused by long-term use of certain psychiatric drugs.

Tourette Syndrome

Occasionally used for the management of severe motor and vocal tics when other treatments fail.

Movement Stabilization

Significantly reduces the intensity of jerky, irregular movements.

Improved Daily Function

Helps patients perform routine tasks like eating or dressing more easily by increasing motor control.

Specific Targeting

Unlike some older neuroleptics, it does not carry the same high risk of causing permanent movement disorders (tardive dyskinesia).

Adjustable Dosing

The gradual titration process allows for a personalized treatment plan based on the patient's unique sensitivity.

Because this medicine lowers levels of mood-regulating chemicals like serotonin, psychological side effects are common and require close monitoring.

Common Side Effects

• Drowsiness or sleepiness (sedation)

• Insomnia (trouble sleeping)

• Nausea

• Fatigue or tiredness

• Anxiety or restlessness (akathisia)

Uncommon Side Effects

• Dizziness

• Difficulty swallowing

• Slowed movements or muscle stiffness (Parkinsonism)

• Increased sweating

Serious Side Effects (Seek Urgent Medical Care)

• Depression and Suicidality: New or worsening depression, agitation, or thoughts of self-harm.

• Neuroleptic Malignant Syndrome (NMS): High fever, severe muscle rigidity, and confusion.

• Severe Parkinsonism: Difficulty speaking, tremors, or a "shuffling" gait that interferes with walking.

• Q-T Prolongation: Irregular heart rhythm or fainting spells.

Enizahex 25 Tablet should be taken exactly as prescribed by your neurologist. It is generally taken one to three times daily. The medication can be taken with or without food. To minimize the risk of side effects, your doctor will start with a low dose and increase it weekly. Do not stop taking this medication suddenly, as your movement symptoms may return quickly and severely. If you miss multiple doses, consult your doctor before restarting.

• Mood Monitoring: This is the most critical part of therapy. Inform your doctor immediately if you feel unusually sad, hopeless, or anxious.

• Fall Prevention: Because this medicine can cause drowsiness and dizziness, move slowly when standing up to avoid falls.

• Avoid Overheating: Tetrabenazine can interfere with your body's ability to regulate temperature; stay hydrated and avoid extreme heat.

• Routine Check-ups: Ensure you attend all follow-up appointments so your doctor can check for signs of Parkinson-like stiffness.

• Alcohol (Severe): Increases CNS depression, leading to extreme sleepiness and impaired coordination.

• Caffeine (Moderate): May counteract some of the sedative effects but could also worsen restlessness or anxiety.

• MAO Inhibitors (Severe): Do not take within 14 days of an MAOI (e.g., phenelzine), as this can cause a dangerous spike in blood pressure.

• Reserpine (Severe): Should not be used with other monoamine depleters.

• Antidepressants (High): Drugs like Fluoxetine or Paroxetine (strong CYP2D6 inhibitors) can double the levels of Tetrabenazine in your blood; dose reduction is required.

• Neuroleptics (Moderate): Using with antipsychotics (e.g., Haloperidol) increases the risk of Parkinsonism and NMS.

• Depression/Suicidality (Severe): Contraindicated in patients who are actively suicidal or have untreated/undertreated depression.

• Liver Disease (Severe): Should not be used in patients with liver impairment.

• Parkinson’s Disease (Moderate): May worsen symptoms like tremors and rigidity.

If you miss a dose, skip it and take your next dose at the regular time. Do not take two doses at once. If you miss more than two days of treatment, contact your doctor, as your dose may need to be adjusted or restarted from the beginning.