Dtmol AP 100mg/325mg Tablet

Dtmol AP 100mg/325mg Tablet is a fixed‑dose combination medicine that contains Diclofenac, a non‑steroidal anti‑inflammatory drug (NSAID), and Paracetamol, an analgesic (pain-reliever) and antipyretic (fever-reducer). Together, they are used to relieve pain, inflammation, and fever associated with conditions such as arthritis, muscle and joint pain, backache, dental pain, menstrual cramps, and post‑operative discomfort.

Diclofenac works by blocking cyclo‑oxygenase (COX) enzymes, which are responsible for producing prostaglandins (chemical messengers that cause pain, swelling, and inflammation). By reducing prostaglandin levels, Diclofenac helps ease stiffness and discomfort. Paracetamol complements this effect by acting centrally in the brain to lower pain perception and reduce fever, with minimal stomach irritation.

This combination provides enhanced pain relief compared to either medicine alone, offering faster and more effective symptom control. Dtmol AP 100mg/325mg Tablet is generally prescribed for short‑term use and should always be taken under medical supervision, as prolonged or excessive use may increase the risk of side effects such as stomach irritation, liver damage, or kidney problems.

Dtmol AP 100mg/325mg Tablet is used to treat different types of pain, swelling, and fever. Doctors may prescribe it for:

Musculoskeletal Pain:

Pain, swelling, and stiffness associated with sprains, strains, low back pain, and shoulder pain.

Osteoarthritis and Rheumatoid Arthritis:

Short-term relief of flare-ups and acute exacerbations of chronic joint pain.

Ankylosing Spondylitis:

Treatment of pain and inflammation in the spine.

Dental Pain:

Pain following dental procedures, toothaches, and inflammation of the gums.

Post-operative Pain:

Management of moderate pain and swelling after minor surgical interventions.

Dysmenorrhea:

Relief from painful menstrual cramps.

Fever:

Reduction of high body temperature associated with the painful conditions listed above.

Comprehensive Pain Relief:

Addresses pain through both peripheral anti-inflammatory action (Aceclofenac) and central analgesic effects (Paracetamol).

Synergistic Effect:

The combination provides a greater degree of pain relief than can be achieved by increasing the dose of either drug alone.

Fast Onset:

Paracetamol ensures a relatively quick onset of pain relief.

Anti-Inflammatory Potency:

Aceclofenac effectively reduces inflammation and swelling, particularly in joint tissues.

Fever Control:

Provides reliable reduction of fever (antipyretic action).

When taken as directed, Dtmol AP 100mg/325mg Tablet is generally safe. Side effects are usually rare, mild, and temporary.

Common Side Effects (usually mild and resolve on discontinuation):

• Nausea, Vomiting
• Indigestion (Dyspepsia), Heartburn, Abdominal pain
• Diarrhoea or Constipation
• Headache, Dizziness
• Drowsiness

Serious Side Effects (Seek urgent medical attention if you experience):

• Gastrointestinal Bleeding: Black, tarry stools, or vomiting blood/material resembling coffee grounds.
• Hepatotoxicity: Yellowing of the skin or eyes (Jaundice), dark urine, or persistent upper right quadrant abdominal pain (signs of liver damage from Paracetamol overdose).
• Allergic Reactions: Swelling of the face, lips, tongue, or throat; difficulty breathing; or severe skin reactions (e.g., Stevens-Johnson Syndrome).
• Cardiovascular Events: Chest pain, shortness of breath, sudden weakness, or slurred speech (associated with long-term NSAID use).
• Renal Impairment: Changes in the amount or frequency of urination.

• Dosage: Take the tablet exactly as prescribed by your doctor. The usual adult dose is one tablet 2 times a day (morning and evening).
• Administration: Swallow the tablet whole with a full glass of water. Do not chew, crush, or break the tablet.
• Timing: To reduce the risk of gastrointestinal irritation, it is crucial to take Dtmol AP 100mg/325mg Tablet with food or milk immediately after a meal or snack.
• Duration: Use the medication for the shortest effective duration to control your symptoms, typically not exceeding 7 to 10 days, unless otherwise directed by a physician.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Do not take two doses at once.

Dtmol AP 100mg/325mg Tablet is a combination medicine that relieves pain and reduces inflammation by using two complementary approaches.

• Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that works at the site of pain and inflammation. It blocks the production of chemicals called prostaglandins, which are responsible for swelling, pain, and stiffness. By lowering prostaglandin levels, Aceclofenac helps reduce inflammation and discomfort in joints, muscles, and tissues.
• Paracetamol (Acetaminophen) works primarily in the brain and spinal cord. It helps block pain signals and reduce fever, providing fast relief from discomfort and complementing the anti-inflammatory effects of Aceclofenac.
• Together, Dtmol AP 100mg/325mg Tablet often works faster and more effectively than either medicine alone, and using lower doses can help minimise the risk of side effects.

• Follow strict dosing limits: Never exceed the prescribed dose. Ensure total Paracetamol intake from all sources does not exceed 4000 mg (4 grams) in 24 hours.
• Protect your stomach: Always take Dtmol AP 100mg/325mg Tablet with food. If you have a history of ulcers, your doctor may prescribe a protective medicine (like a PPI).
• Check other medicines: Review labels of cold/flu remedies to ensure they do not also contain Paracetamol to avoid toxicity.
• Watch for warning signs: Seek medical help immediately for black stools, jaundice (yellow skin/eyes), or persistent abdominal pain.

• Store Dtmol AP 100mg/325mg Tablet in its original packaging at room temperature, ideally between 20°C and 25°C (68°F to 77°F).
• Keep the medicine away from excessive heat, moisture, and direct sunlight.
• Always keep the tablets out of the reach of children and pets.
• Do not use the medicine after the expiry date printed on the packaging.

• Food: Beneficial interaction. Taking the tablet with food reduces the likelihood of gastric irritation.
• Alcohol: Severe Interaction. Significantly increases the risk of liver damage and gastrointestinal bleeding.

• Other NSAIDs/Aspirin: Increased risk of gastrointestinal bleeding.
• Anticoagulants (e.g., Warfarin): Enhanced effect of blood thinners, increasing bleeding risk.
• Corticosteroids: Increased risk of stomach ulcers.
• Antihypertensives: Aceclofenac may reduce the effectiveness of blood pressure-lowering drugs.
• Lithium: Aceclofenac can increase blood levels of Lithium, potentially leading to toxicity.

Dtmol AP 100mg/325mg Tablet should be used with extreme caution or is contraindicated in:

• Gastrointestinal Ulcers: Active or recurrent peptic ulcer disease or bleeding.
• Severe Hepatic Impairment: Pre-existing liver disease.
• Severe Renal Impairment: Significant kidney dysfunction.
• Cardiovascular Disease: History of heart failure, stroke, or uncontrolled hypertension.
• Asthma: Especially in patients with aspirin-sensitive asthma.

The usual adult dose of Dtmol AP 100mg/325mg Tablet is one tablet taken twice daily, preferably after meals to reduce stomach irritation.

• Maximum Aceclofenac: Do not exceed 200 mg per day.
• Maximum Paracetamol: Do not exceed 4,000 mg per day from all sources, including other medications containing Paracetamol, to avoid liver damage. Elderly patients or those with liver or kidney problems should use the lowest effective dose under medical supervision. Avoid taking additional NSAIDs or Paracetamol-containing medicines at the same time unless prescribed by your doctor.

An overdose is a medical emergency. The critical risk is severe liver failure due to Paracetamol, which may not show symptoms for 24–48 hours. Signs include nausea, stomach pain, and drowsiness. Seek immediate medical attention even if no symptoms are present.