Alikast DX 400/10mg Tablet 10s

Alikast Dx 400 10mg Tablet 10s is a combination respiratory medication containing Doxofylline and Montelukast in a sustained-release formulation. It is used to manage chronic respiratory conditions, including asthma, allergic airway disease, exercise-induced bronchospasm, and chronic obstructive pulmonary disease (COPD). Doxofylline helps relax airway muscles and improve breathing, while Montelukast reduces airway inflammation and prevents bronchospasm triggered by allergens. Together, they provide long-lasting relief from wheezing, chest tightness, cough, and breathlessness.

Alikast Dx 400 10mg Tablet 10s is designed for patients who require long-term control of airway inflammation and bronchial hyper-responsiveness. This fixed-dose combination works through complementary mechanisms: Doxofylline, a xanthine derivative, acts as a bronchodilator by relaxing bronchial smooth muscle and improving airflow. Unlike older methylxanthines, it has a lower tendency to cause palpitations or nervous system side-effects. Montelukast is a leukotriene receptor antagonist (LTRA) that blocks inflammatory mediators responsible for airway swelling, mucus production, and constriction.

Sustained-release (SR) delivery maintains stable therapeutic levels for extended symptom control, reducing the need for multiple daily doses. It is particularly beneficial in individuals with nocturnal asthma, persistent allergic symptoms, or those with inadequate response to inhaled therapies alone.

Alikast Dx 400 10mg Tablet 10s plays a vital role in maintaining day-to-day respiratory stability, preventing flare-ups, and improving overall quality of life in patients living with chronic airway disease.

Alikast Dx 400 10mg Tablet 10s is prescribed under medical guidance for conditions requiring long-term respiratory management:

1. Bronchial Asthma

Used in mild to moderate persistent asthma to:

1. Improve airflow

2. Reduce breathlessness and wheezing

3. Control nighttime symptoms

4. Prevent recurrent exacerbations

2. Allergic Asthma

Helps manage asthma triggered by allergens such as:

1. Dust mites

2. Pollen

3. Pet dander

4. Smoke or environmental pollutants

Montelukast prevents allergic inflammatory pathways responsible for bronchospasm.

3. Exercise-Induced Bronchoconstriction (EIB)

Athletes and individuals who develop symptoms after exertion benefit from improved airway protection and enhanced breathing capacity.

4. Chronic Obstructive Pulmonary Disease (COPD)

Used as supportive therapy to:

1. Reduce flare-ups

2. Improve breathing capacity

3. Control inflammation-associated airway narrowing

5. Chronic Cough Associated with Airway Hyper-Responsiveness

Helps manage a persistent cough caused by allergic triggers or airway hypersensitivity.

6. Seasonal and Perennial Allergic Rhinitis (Adjunct Use)

Reduces rhinitis-associated symptoms such as sneezing, mucus production, and nasal obstruction when respiratory symptoms coexist.

1. Dual Mechanism for Better Symptom Control

1. Doxofylline opens the air passages

2. Montelukast prevents inflammation and bronchospasm

3. This combination provides more substantial and sustained relief than monotherapy.

2. Long-Acting Control

The sustained-release formulation offers prolonged symptom protection throughout the day and night.

3. Better Tolerance than Traditional Xanthines

Doxofylline is associated with:

1. Fewer palpitations

2. Reduced tremors

3. Lower likelihood of gastric irritation or nervousness

4. Reduces Frequency and Severity of Asthma Attacks

Long-term use helps minimise emergency inhaler usage and hospital visits.

5. Suitable as an Add-On Therapy

Ideal for patients not adequately responding to inhaled corticosteroids or bronchodilators alone.

6. Lower Risk of Steroid Exposure

In some cases, the combination may reduce the required dose of inhaled or systemic steroids.

7. Improved Quality of Life

Patients experience better exercise tolerance, restful sleep, and daily functional improvement.

Alikast Dx 400 10mg Tablet 10s is generally well tolerated, and most people using it do not experience serious problems. When side effects do appear, they are often mild, short-lived, and tend to improve as the body adjusts to the treatment.

Common Side Effects

These effects are usually mild and do not require stopping the medicine unless persistent or bothersome:

1. Headache

2. Mild stomach upset or abdominal discomfort

3. Dryness of mouth

4. Nausea, indigestion, or bloating

5. Tiredness or low energy

6. Light dizziness

Less Common Side Effects

Some individuals may experience slightly stronger symptoms, especially during the first few days of treatment:

1. Sensation of rapid or forceful heartbeat (palpitations)

2. Difficulty sleeping or altered sleep pattern

3. Feeling unusually restless or irritable

4. Muscle cramps or weakness

Rare but Important Side Effects

Although rare, specific reactions need prompt medical attention. Stop the medicine and consult a doctor if you notice:

1. Persistent or worsening chest pain

2. Severe or irregular palpitations

3. Noticeable changes in behaviour, mood swings, unusual irritability, or agitation

4. Marked tremors or uncontrolled shaking

5. Signs of allergy, such as swelling of the face or lips, an itchy skin rash, wheezing, or difficulty breathing

Allergic symptoms require immediate medical care.

1. Take the tablet exactly as prescribed, typically once daily, preferably in the evening, unless advised differently.
2. Swallow the tablet whole with a glass of water. Do not crush, split, or chew the sustained-release (SR) tablet, as this may affect how the medicine is released in the body.
3. Alikast Dx 400 10mg Tablet 10s may be taken with or without food. If you experience acidity or nausea, taking it after meals may be more comfortable.
4. Continue using prescribed inhalers or other asthma/COPD medicines unless your doctor advises a change.

Consistency is essential. Alikast Dx 400 10mg Tablet 10s is intended for maintenance therapy. It does not work as a rescue treatment for sudden breathing difficulty or asthma attacks. For emergencies, continue using your prescribed quick-relief inhaler.

1. The medicine can be taken with or after meals, which may help reduce gastric discomfort.
2. Limiting beverages that contain high caffeine levels (such as strong coffee, energy drinks, or cola) is advisable, as caffeine may intensify stimulant-like effects sometimes associated with xanthine derivatives.

Tell your doctor about all prescription, non-prescription, or herbal medicines you are currently using. Some medicines may interact with Alikast Dx 400 10mg Tablet 10s, leading to reduced effect or increased side effects. Notable interacting medicines include:

1. Theophylline or other bronchodilators

2. Warfarin

3. Beta-blockers

4. Certain antibiotics, such as ciprofloxacin or erythromycin

5. Antiepileptic medications

Any changes to medication should be made only after consulting a healthcare professional.

Alikast Dx 400 10mg Tablet 10s should be used cautiously in people with the following conditions:

1. Peptic or gastric ulcers

2. Severe liver disease

3. Hyperthyroidism

4. Heart rhythm disorders or cardiovascular disease

These conditions may influence medicine tolerance or increase the likelihood of side effects.

Accidental or purposeful overdose should be treated as a medical emergency. Symptoms of overdose may include:

1. Rapid or irregular heartbeat

2. Persistent nausea or vomiting

3. Tremors or shaking

4. Marked restlessness or agitation

Immediate medical evaluation is essential to prevent complications.

1. Take the missed dose as soon as you remember.

2. If it is close to the next scheduled dose, skip the missed dose.

3. Do not take extra tablets to make up for a missed dose, as this may increase the risk of side effects.