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Pyrimethamine

Uses

Pyrimethamine is used in the treatment of malaria.

How it Works

How Pyrimethamine works Pyrimethamine is an antiparasitic medication that treats malaria. It functions by increasing the levels of heme in the blood, a substance toxic to the malarial parasite. This action kills the parasite and prevents the infection from spreading.

Side Effects

Common side effects of Pyrimethamine include abnormal bruising, abnormal skin pigmentation, anemia (low number of red blood cells), changes in blood test results, dizziness, headache, vomiting, weakness, diarrhea, and nausea.

Expert Advice

  • Pyrimethamine should be taken with food to prevent stomach upset.
  • Finish the prescribed course, even if you start to feel better; stopping it early may allow the infection to return and become harder to treat.
  • Tips to reduce the chance of being bitten by mosquitoes:
    • Wear light-colored and covered clothing when outdoors after sunset.
    • Use insect repellent creams or sprays on exposed skin.
    • Spray to eliminate any mosquitoes that may have entered rooms despite screening.
  • Inform your doctor if you have kidney, liver, or heart disease.

Other Combinations

Pyrimethamine + Sulfamethoxazole

Artesunate + Pyrimethamine + Sulphadoxine

Pyrimethamine + Sulphadoxine

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Frequently asked questions

Pyrimethamine is safe when taken as prescribed by your doctor. Adhere to the recommended dosage and duration, and report any bothersome side effects to your doctor.
Pyrimethamine should be avoided by individuals allergic to it or any of its components. If you are unsure about allergies or using it for the first time, consult your doctor.
If you miss a dose of Pyrimethamine, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with the scheduled one. Do not double the dose to compensate for the missed one.
Prevent malaria by avoiding mosquito bites through protective clothing, using mosquito nets, and applying insect repellent. Consult your doctor about the need for antimalarial tablets, and if prescribed, take them as directed and complete the course. Seek medical advice if you experience malaria symptoms.
Do not discontinue Pyrimethamine without consulting your doctor, even if you feel better. Symptoms may improve before the infection is fully treated, so complete the prescribed course.
Malaria symptoms can appear as soon as 7 days after being bitten by an infected mosquito, with an incubation period typically ranging from 7 to 18 days. In some cases, symptoms may take up to a year to develop, initially presenting as flu-like symptoms including fever, chills, muscle pain, vomiting, headaches, and diarrhea.
Before starting Pyrimethamine, inform your doctor about any existing health conditions, particularly kidney or heart issues, as these may require dose adjustments. Also, disclose all medications you are taking and notify your doctor if you are pregnant or breastfeeding.
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