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Midodrine

Uses

Midodrine is used in the treatment of low blood pressure.

How it Works

How Midodrine works Midodrine is an alpha-adrenergic agonist. It functions by activating specific receptors on blood vessels, leading to their constriction and an increase in blood pressure.

Side Effects

Common side effects of Midodrine include nausea, piloerection, supine hypertension, discomfort when urinating, stomatitis (inflammation of the mouth), dyspepsia, urinary retention, and itching.

Expert Advice

  • Take Midodrine at least 4 hours before bedtime to avoid the risk of high blood pressure at night.
  • Monitor your blood pressure regularly while taking this medication.
  • Inform your doctor if you have a history of prostate disorders or blood circulation problems.
  • Notify your doctor immediately if you experience symptoms such as chest pain, palpitations, headache, shortness of breath, or blurred vision.
  • Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Other Combinations

Frequently asked questions

Take Midodrine as prescribed by your doctor, orally with or without food. Swallow the tablet whole with water, usually three times a day (morning, midday, late afternoon before 6 PM), with at least 3 hours between doses. The last dose should be taken before an evening meal and at least 4 hours before bedtime.
Midodrine is contraindicated in individuals with allergies to its components, severe heart disease, bradycardia, hypertension, and conditions that cause arterial constriction. It should also be avoided in patients with enlarged prostate, urinary retention, pheochromocytoma, severe kidney disease, hyperthyroidism, diabetic vision problems, and narrow-angle glaucoma.
Midodrine typically takes about 1 hour to take effect, but its action lasts only 2-3 hours.
Midodrine may slightly slow heart rate. Caution is advised when used with other medications (e.g., beta blockers, digitalis) that can further reduce heart rate. Patients should be monitored for symptoms of bradycardia.
Yes, Midodrine may cause high blood pressure when lying flat (supine hypertension). It should only be used by individuals whose low blood pressure impacts daily life and who have not responded to other treatments.
Combining Midodrine and metoprolol can significantly slow heart rate. Use caution and inform your doctor if you experience slow pulse, dizziness, or fainting, as dosage adjustments may be necessary.
You should avoid lying down immediately after taking Midodrine due to the risk of supine hypertension. It is recommended to take the last daily dose at least 4 hours before bedtime and consider elevating your head to reduce nighttime risks.
Prior to starting Midodrine, blood pressure and kidney and liver function tests may be necessary. During treatment, consistently monitor blood pressure and heart rate, especially after lying down.
Symptoms of supine hypertension include chest pain, palpitations, shortness of breath, headache, and blurred vision. If you experience these symptoms, contact your doctor immediately, as they may adjust your Midodrine dosage or discontinue treatment.
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