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Memantine

Uses

Memantine is used in the treatment of Alzheimer's disease. It is indicated for patients with moderate to severe Alzheimer's disease.

How it Works

How Memantine works Memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist. Memory loss in Alzheimer’s disease is caused by excessive production of glutamate, a chemical messenger in the brain, which is mediated by NMDA receptors. Memantine works by blocking the action of NMDA receptors and regulating the production of glutamate, which is involved in the transmission of nerve signals. This mechanism helps prevent memory loss in Alzheimer’s disease.

Side Effects

Common side effects of Memantine include dizziness, headache, balance disorder (loss of balance), weight gain, drug allergy, high blood pressure, shortness of breath, and gastrointestinal intolerance.

Expert Advice

  • You have been prescribed Memantine to slow the progression of Alzheimer's disease.
  • It is well tolerated and has fewer side effects compared to other similar medications.
  • Exercise caution while driving or engaging in activities that require concentration until you understand how Memantine affects you.
  • Inform your doctor if you have a history of:
    • Seizures
    • Kidney disease
    • Heart disease
    • Liver disease
  • Notify your doctor if you are:
    • Pregnant
    • Planning to conceive
    • Breastfeeding

Other Combinations

Donepezil + Memantine

Frequently asked questions

Dementia is a syndrome characterized by a decline in memory, thinking, behavior, and daily functioning. It is a leading cause of disability among the elderly, with Alzheimer's disease being the most prevalent form, accounting for 60-70% of cases.
Memantine may enhance memory by protecting NMDA receptors in the brain from excessive glutamate, which can lead to degeneration, thus potentially improving cognitive function.
Yes, Memantine may cause drowsiness and has a minor to moderate effect on driving and operating machinery; caution is advised for outpatients.
Memantine does not have abuse potential and may even help prevent the excessive use of addictive substances like morphine or ethanol.
No, Memantine should not be discontinued without consulting a doctor, even if symptoms improve, as it only manages Alzheimer's symptoms and does not provide a cure.
Memantine should be taken orally once daily at the same time, with or without food, and swallowed with water.
Yes, Memantine can be safely combined with donepezil without increasing adverse effects. This combination may enhance cognitive function and alleviate symptoms but does not cure Alzheimer's disease.
Symptoms of Memantine overdose may include tiredness, weakness, drowsiness, confusion, hallucinations, vomiting, diarrhea, vertigo, agitation, aggression, and difficulty walking.
Yes, Memantine may interact with hydrochlorothiazide (HCT) by reducing its effectiveness. Additionally, medications like procainamide and quinidine may elevate Memantine levels, increasing the risk of toxicity.
Memantine is an NMDA receptor antagonist that reduces abnormal brain activity, potentially improving cognitive function and slowing the decline in abilities in Alzheimer's patients. However, it does not cure the disease.
Memantine may take 3 to 8 hours to begin working, with a follow-up assessment recommended after 4 weeks and then again after 6 months.
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