Epalrestat, Methylcobalamin, and Pregabalin are used in the treatment of diabetic nerve pain.
How Epalrestat, Methylcobalamin, and Pregabalin work Epalrestat, Methylcobalamin, and Pregabalin is a combination of three medicines used to treat diabetic nerve disease. Epalrestat is an aldose reductase inhibitor that blocks the accumulation of sorbitol in cells, which contributes to diabetic nerve disease. Methylcobalamin is a form of vitamin B that aids in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. Pregabalin is an alpha-2-delta ligand that decreases pain by modulating the calcium channel activity of nerve cells.
Common side effects of Epalrestat, Methylcobalamin, and Pregabalin include nausea, vomiting, drowsiness, dizziness, tiredness, uncoordinated body movements, and increased liver enzymes.
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