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Entacapone

Uses

Entacapone is used in the treatment of Parkinson's disease.

How it Works

How Entacapone works Entacapone is a selective reversible inhibitor that is administered in combination with levodopa. It functions by inhibiting a chemical messenger known as catechol-O-methyl transferase (COMT), which helps increase the levels of dopamine in the body. An adequate amount of dopamine is essential for the brain to effectively coordinate body movements. This mechanism is how entacapone aids in the management of Parkinson's disease.

Side Effects

Common side effects of Entacapone include nausea, confusion, hallucinations, urine discoloration, insomnia (difficulty sleeping), diarrhea, ischemic heart disease, abdominal pain, and involuntary muscle movements.

Expert Advice

  • You have been prescribed Entacapone to enhance the effectiveness of levodopa for the treatment of Parkinson's disease.
  • This medication may cause significant drowsiness; avoid driving or engaging in activities that require concentration until you understand how it affects you.
  • To reduce the risk of dizziness or fainting, rise slowly from a sitting or lying position.
  • Inform your doctor if you experience impulsive behaviors, unusual actions, or an abnormally high sex drive.
  • Consult your doctor if you develop hallucinations or any other behavioral changes.
  • Diarrhea is a common side effect of this medication; therefore, ensure you drink plenty of fluids and monitor for any weight loss.
  • Do not be alarmed if you notice reddish-brown discoloration in your urine, as this is harmless.
  • Do not discontinue the medication abruptly without consulting your doctor.

Other Combinations

Carbidopa + Entacapone + Levodopa

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Frequently asked questions

Yes, the combination of Entacapone and levodopa may lead to excessive daytime sleepiness and sudden sleep onset. Consult your doctor if these symptoms occur.
No, Entacapone does not affect fertility, but it should be avoided by pregnant or lactating women due to insufficient safety data.
No, Entacapone is not a dopamine agonist; it is a selective and reversible COMT inhibitor that enhances and sustains levodopa levels.
Entacapone is classified as a COMT (catechol-O-methyltransferase) inhibitor.
Yes, Entacapone may cause urine to turn brownish-orange, which is a common and harmless effect.
Entacapone can be taken at any time but should ideally be taken around the same time each day for better adherence.
No, Entacapone does not cross the blood-brain barrier but helps prolong the benefits of levodopa doses.
Impulse control disorders involve urges to engage in unusual behaviors, such as compulsive gambling or excessive spending. If experienced, consult your doctor for possible dose adjustments.
No, Entacapone should not be crushed or split. It should be taken whole with a full glass of water at the same time as a dose of levodopa.
If you accidentally take more than the recommended dose, you may experience confusion, sleepiness, and other symptoms. Seek immediate medical attention.
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