Sitaglip D 10/100mg Tablet 10s

Sitaglip D 10 100mg Tablet 10s is an oral anti-diabetic medicine used to manage Type 2 Diabetes Mellitus (T2DM) in adults. It combines Dapagliflozin, an SGLT2 (Sodium-Glucose Co-Transporter 2) inhibitor, and Sitagliptin, a DPP-4 (Dipeptidyl Peptidase-4) inhibitor. Dapagliflozin helps lower blood sugar by increasing the excretion of glucose through urine, while Sitagliptin enhances insulin secretion and reduces glucagon release in a glucose-dependent manner. Together, they provide complementary blood sugar control, helping improve both fasting and post-meal glucose levels with a low risk of hypoglycaemia when used appropriately.

Sitaglip D 10 100mg Tablet 10s is an oral anti-diabetic medication designed to help adults with Type 2 Diabetes Mellitus (T2DM) achieve better blood sugar control. It combines Dapagliflozin, an SGLT2 (Sodium-Glucose Co-Transporter 2) inhibitor, with Sitagliptin, a DPP-4 (Dipeptidyl Peptidase-4) inhibitor. This combination targets high blood sugar through complementary mechanisms.

Dapagliflozin works in the kidneys by preventing glucose reabsorption, promoting the removal of excess glucose through urine. This process lowers blood sugar independently of insulin and may also support modest weight loss and help control blood pressure.

Sitagliptin enhances the activity of incretin hormones such as Glucagon-like peptide-1 (GLP-1) and Glucose-dependent insulinotropic polypeptide (GIP), which are released after meals. These hormones increase insulin secretion and reduce glucagon release in a glucose-dependent manner, helping the body manage post-meal blood sugar effectively while minimising the risk of low blood sugar (hypoglycaemia).

By combining these two medicines, Sitaglip D 10 100mg Tablet 10s addresses both insulin-dependent and insulin-independent pathways. This helps reduce both fasting and post-meal glucose levels, providing stable and sustained glycemic control throughout the day. The combination supports long-term management of diabetes and may help reduce the risk of complications affecting the eyes, kidneys, nerves, and cardiovascular system.

Sitaglip D 10 100mg Tablet 10s is generally well tolerated when used as prescribed. It should be taken as directed by a healthcare professional, usually with or after meals, to improve tolerability and minimise gastrointestinal discomfort. Regular monitoring of blood sugar and kidney function is recommended during treatment.

Sitaglip D 10 100mg Tablet 10s is indicated for:

• Type 2 Diabetes Mellitus (T2DM): Used as an adjunct to diet and exercise to improve glycemic control in adults.
• Combination Therapy: For patients who are not sufficiently controlled on Dapagliflozin or Sitagliptin alone, or those already taking both drugs as separate tablets.

• Dual Action for Better Blood Sugar Control: Dapagliflozin removes excess sugar via the kidneys, while Sitagliptin increases insulin release and lowers glucagon in response to food.
• Cardiovascular and Renal Support: SGLT2 inhibitors like Dapagliflozin are known to provide protection for the heart and kidneys in diabetic patients.
• Low Risk of Hypoglycaemia: Both medicines work in a way that is less likely to cause dangerously low blood sugar when used without insulin or sulfonylureas.
• Weight and Blood Pressure Management: The excretion of glucose can lead to modest weight loss and a slight reduction in blood pressure.
• Convenient Treatment: Combines two therapeutic classes in one dose, simplifying the daily treatment routine.

When taken as directed, Sitaglip D 10 100mg Tablet 10s is generally well-tolerated. Side effects are typically mild and often diminish as the body adjusts to the medication.

Common Side Effects:

• Genital yeast (fungal) infections
• Urinary tract infections (UTI)
• Nasopharyngitis (cold-like symptoms)
• Headache or Dizziness
• Increased urination

Serious Side Effects (Stop taking the medicine and seek urgent medical attention if you experience):

• Pancreatitis (Sitagliptin): Severe and persistent stomach pain that may radiate to your back.
• Diabetic Ketoacidosis (Dapagliflozin): A serious condition where the blood becomes too acidic. Symptoms include nausea, vomiting, stomach pain, and unusual tiredness.
• Dehydration: Severe thirst, dry mouth, or lightheadedness.
• Serious Allergic Reactions: Swelling of the face, lips, tongue, or throat (angioedema).

• Dosage: Usually taken once daily, or as prescribed by your doctor.
• Administration: The tablet can be taken with or without food.
• Consistency: Swallow the tablet whole with a glass of water at the same time every day to maintain a steady effect.

• Stay Hydrated: Drink plenty of water throughout the day to support kidney function.
• Personal Hygiene: Maintain good genital hygiene to reduce the risk of yeast infections.
• Sick Day Rules: If you are unable to eat or drink due to illness, contact your doctor, as you may need to pause the medication.
• Monitor Feet: Perform daily foot checks and maintain regular eye and dental exams.

Store in a cool, dry place below 30°C. Protect from moisture and light by keeping tablets in their original blister pack. Keep away from children.

• Hydration: It is important to maintain adequate water intake to prevent dehydration while on Dapagliflozin.
• Balanced Diet: Continue following a diabetic-friendly meal plan to support the medication's efficacy.

• Diuretics (Water Pills): May increase the risk of dehydration and low blood pressure.
• Insulin or Sulfonylureas: Combining these with Sitaglip D 10 100mg Tablet 10s may require a dose adjustment to prevent low blood sugar.
• NSAIDs: Long-term use of certain painkillers can affect kidney function and should be monitored.

• Renal Impairment: The glucose-lowering effect is reduced in patients with kidney problems.
• History of Pancreatitis: Use with caution due to the Sitagliptin component.
• Hypotension: May cause low blood pressure, especially in elderly patients or those on diuretics.

Standard dosing is usually one tablet once daily. Follow the specific instructions provided by your healthcare provider.

An overdose can lead to severe dehydration or gastrointestinal distress. Action Required: Seek emergency medical care or contact a poison control centre immediately if an overdose is suspected.

Take the missed dose as soon as you remember. If it is nearly time for the next dose, skip the missed one. Never "double up" on doses.