Vitamin A (Retinol) + Vitamin B12 (Methylcobalamin) + Vitamin B3 (Niacin) + Vitamin B5 (Pantothenic Acid) + Vitamin B6 (Pyridoxine) + Vitamin B2 (Riboflavin) + Vitamin B1 (Thiamine) + Vitamin D3 (Cholecalciferol) + Zinc (Elemental Zinc) is a comprehensive multi-nutrient formulation combining fat-soluble vitamins A and D3, the full B-vitamin complex, and elemental zinc. Together these nutrients support immune function, neurological health, energy metabolism, skin integrity, bone health, and antioxidant defence. It is used in the prevention and treatment of multiple nutritional deficiencies and as a daily supplement in individuals with increased requirements. Always use Vitamin A (Retinol) + Vitamin B12 (Methylcobalamin) + Vitamin B3 (Niacin) + Vitamin B5 (Pantothenic Acid) + Vitamin B6 (Pyridoxine) + Vitamin B2 (Riboflavin) + Vitamin B1 (Thiamine) + Vitamin D3 (Cholecalciferol) + Zinc (Elemental Zinc) exactly as directed by your doctor.

Vitamin A (Retinol) + Vitamin B12 (Methylcobalamin) + Vitamin B3 (Niacin) + Vitamin B5 (Pantothenic Acid) + Vitamin B6 (Pyridoxine) + Vitamin B2 (Riboflavin) + Vitamin B1 (Thiamine) + Vitamin D3 (Cholecalciferol) + Zinc (Elemental Zinc) combines nine essential micronutrients with complementary roles across immune function, energy metabolism, neurological health, and cellular protection.

Vitamin A (retinol) supports vision, epithelial integrity, immune cell development, and mucosal barrier maintenance. Thiamine (B1), riboflavin (B2), niacin (B3), and pantothenic acid (B5) serve as coenzymes in mitochondrial energy production, fatty acid metabolism, and DNA repair. Pyridoxine (B6) supports amino acid metabolism, neurotransmitter synthesis, and homocysteine regulation. Methylcobalamin (B12) maintains myelin integrity, supports axonal regeneration, and works with B6 in homocysteine remethylation.

Vitamin D3 (cholecalciferol) regulates calcium absorption, bone mineralisation, and immune modulation. Zinc supports over 300 enzymatic reactions including immune cell proliferation, wound healing, DNA replication, and antioxidant defence through superoxide dismutase activity.

The uses of Vitamin A (Retinol) + Vitamin B12 (Methylcobalamin) + Vitamin B3 (Niacin) + Vitamin B5 (Pantothenic Acid) + Vitamin B6 (Pyridoxine) + Vitamin B2 (Riboflavin) + Vitamin B1 (Thiamine) + Vitamin D3 (Cholecalciferol) + Zinc (Elemental Zinc) are as follows:

• Multiple Nutritional Deficiency States: Vitamin A (Retinol) + Vitamin B12 (Methylcobalamin) + Vitamin B3 (Niacin) + Vitamin B5 (Pantothenic Acid) + Vitamin B6 (Pyridoxine) + Vitamin B2 (Riboflavin) + Vitamin B1 (Thiamine) + Vitamin D3 (Cholecalciferol) + Zinc (Elemental Zinc) corrects and prevents deficiencies of vitamins A, B-complex, D3, and zinc in individuals with inadequate intake or increased requirements.

• Immune Support: Vitamins A, D3, B6, B12, and zinc collectively support innate and adaptive immune function.

• Neurological Health and Neuropathy: B-complex vitamins support nerve conduction, myelin maintenance, and neurotransmitter synthesis in peripheral neuropathy management.

• Bone Health: Vitamin D3 and zinc support calcium metabolism and skeletal mineralisation.

• Skin and Mucosal Health: Vitamins A, B2, B3, and zinc support epithelial integrity and skin barrier function.

• Energy and Metabolic Support: The full B-vitamin complex provides coenzyme support for energy metabolism across all macronutrient pathways.

• Post-Illness Nutritional Repletion: Replenishes micronutrients depleted during illness, surgery, or prolonged hospitalisation.

Here are the benefits of Vitamin A (Retinol) + Vitamin B12 (Methylcobalamin) + Vitamin B3 (Niacin) + Vitamin B5 (Pantothenic Acid) + Vitamin B6 (Pyridoxine) + Vitamin B2 (Riboflavin) + Vitamin B1 (Thiamine) + Vitamin D3 (Cholecalciferol) + Zinc (Elemental Zinc):

• Comprehensive Micronutrient Coverage: Addresses deficiencies across fat-soluble vitamins, the full B-complex, and an essential trace mineral in a single formulation.

• Synergistic Neurological Support: Thiamine, riboflavin, B6, and methylcobalamin together support nerve conduction, myelin integrity, and neurotransmitter synthesis.

• Immune System Modulation: Vitamins A, D3, B6, B12, and zinc collectively regulate innate and adaptive immune responses.

• Bone and Calcium Metabolism Support: Vitamin D3 and zinc promote calcium absorption and bone mineralisation.

• Antioxidant Defence: Riboflavin, niacin, and zinc support cellular antioxidant mechanisms including glutathione regeneration and superoxide dismutase activity.

• Energy Metabolism Support: The B-vitamin complex provides essential coenzymes for carbohydrate, fat, and protein metabolism.

Like all medicines, Vitamin A (Retinol) + Vitamin B12 (Methylcobalamin) + Vitamin B3 (Niacin) + Vitamin B5 (Pantothenic Acid) + Vitamin B6 (Pyridoxine) + Vitamin B2 (Riboflavin) + Vitamin B1 (Thiamine) + Vitamin D3 (Cholecalciferol) + Zinc (Elemental Zinc) may cause side effects in some individuals.

Common Side Effects

• Mild Gastrointestinal Discomfort: Nausea or loose stools may occur, particularly when taken on an empty stomach.

• Altered Urine Colour: Riboflavin causes harmless bright yellow discolouration of urine, which is expected and benign.

• Skin Flushing: Niacin may cause transient flushing or warmth, particularly at higher doses.

Uncommon Side Effects

• Headache: Mild headache may develop during early use.

• Metallic Taste: Some patients report a slight metallic taste with zinc or methylcobalamin.

• Skin Rash: Mild hypersensitivity reactions may occur in sensitive individuals.

Serious Side Effects (Require Immediate Medical Attention)

• Vitamin A Toxicity: Excessive intake may cause headache, visual disturbances, and liver damage. Do not exceed the prescribed dose.

• Vitamin D Toxicity: Hypervitaminosis D may cause hypercalcaemia presenting with nausea, weakness, and confusion.

• Severe Allergic Reaction: Swelling of the face, lips, or throat with difficulty breathing requires urgent medical care.

• Always consult your doctor if side effects persist or worsen.

To ensure safe use:

• Use exactly as prescribed by your doctor.

• Take once daily with a meal containing fat to maximise absorption of fat-soluble vitamins.

• Do not exceed the prescribed dose, particularly for vitamins A and D3 which accumulate in the body.

• Inform your doctor of all other supplements to avoid excessive combined intake.

The B-vitamin complex functions as coenzymes in mitochondrial energy production. Thiamine pyrophosphate, FAD and FMN from riboflavin, and NAD from niacin drive the citric acid cycle and oxidative phosphorylation. Pantothenic acid as coenzyme A supports fatty acid metabolism. Pyridoxal phosphate and methylcobalamin support amino acid metabolism, neurotransmitter synthesis, and homocysteine remethylation.

Vitamin A binds to nuclear retinoid receptors, regulating gene expression for cell differentiation, immune cell development, and mucosal maintenance. Vitamin D3 is converted to calcitriol, which binds vitamin D receptors in intestinal cells, bone, and immune tissue to regulate calcium absorption, bone remodelling, and immune modulation. Zinc acts as a catalytic and structural component in metalloenzymes supporting DNA synthesis, immune cell function, and superoxide dismutase-mediated antioxidant defence.

A few practical measures can help improve outcomes and ensure safe use of Vitamin A (Retinol) + Vitamin B12 (Methylcobalamin) + Vitamin B3 (Niacin) + Vitamin B5 (Pantothenic Acid) + Vitamin B6 (Pyridoxine) + Vitamin B2 (Riboflavin) + Vitamin B1 (Thiamine) + Vitamin D3 (Cholecalciferol) + Zinc (Elemental Zinc):

• Take with a meal containing fat: Fat-soluble vitamins A and D3 require dietary fat for optimal absorption; taking with a main meal significantly improves bioavailability.

• Do not supplement additionally without advice: Fat-soluble vitamins accumulate; additional supplements alongside this formulation risk toxicity.

• Bright yellow urine is expected: Riboflavin causes harmless yellow discolouration and is not a cause for concern.

• Minimise niacin flushing: Taking with food and avoiding hot beverages immediately after reduces niacin-induced skin flushing.

• Monitor vitamin D levels periodically: Long-term supplementation warrants periodic serum 25-hydroxyvitamin D assessment to prevent accumulation.

Proper storage is important to maintain the stability and effectiveness of Vitamin A (Retinol) + Vitamin B12 (Methylcobalamin) + Vitamin B3 (Niacin) + Vitamin B5 (Pantothenic Acid) + Vitamin B6 (Pyridoxine) + Vitamin B2 (Riboflavin) + Vitamin B1 (Thiamine) + Vitamin D3 (Cholecalciferol) + Zinc (Elemental Zinc):

• Store at room temperature: Keep away from heat, moisture, and direct sunlight.

• Keep in original packaging: Protects fat-soluble and light-sensitive components including vitamins A, D3, and riboflavin.

• Keep out of reach of children: Fat-soluble vitamin overdose, particularly vitamins A and D3, can be serious in children.

• Check expiry before use: Do not use after the expiry date printed on the packaging.

Vitamin A (Retinol) + Vitamin B12 (Methylcobalamin) + Vitamin B3 (Niacin) + Vitamin B5 (Pantothenic Acid) + Vitamin B6 (Pyridoxine) + Vitamin B2 (Riboflavin) + Vitamin B1 (Thiamine) + Vitamin D3 (Cholecalciferol) + Zinc (Elemental Zinc) may generally be taken without strict dietary restrictions. However:

• Take with a fat-containing meal: Maximises absorption of vitamins A and D3.

• Avoid excessive alcohol: Depletes B vitamins, impairs fat-soluble vitamin metabolism, and reduces zinc absorption.

• Avoid additional multivitamin supplements: Combining with other products increases fat-soluble vitamin toxicity risk.

Vitamin A (Retinol) + Vitamin B12 (Methylcobalamin) + Vitamin B3 (Niacin) + Vitamin B5 (Pantothenic Acid) + Vitamin B6 (Pyridoxine) + Vitamin B2 (Riboflavin) + Vitamin B1 (Thiamine) + Vitamin D3 (Cholecalciferol) + Zinc (Elemental Zinc) may interact with the following medicines:

• Retinoids: Concurrent vitamin A with systemic retinoids significantly increases toxicity risk and is contraindicated.

• Anticonvulsants: Phenytoin and carbamazepine reduce B vitamin levels; high-dose B6 may reduce anticonvulsant effectiveness.

• Thiazide Diuretics: May increase hypercalcaemia risk when combined with vitamin D3.

• Statins: Niacin at higher doses may interact with statin therapy.

• Levothyroxine: Zinc reduces levothyroxine absorption; separate doses by at least four hours.

Vitamin A (Retinol) + Vitamin B12 (Methylcobalamin) + Vitamin B3 (Niacin) + Vitamin B5 (Pantothenic Acid) + Vitamin B6 (Pyridoxine) + Vitamin B2 (Riboflavin) + Vitamin B1 (Thiamine) + Vitamin D3 (Cholecalciferol) + Zinc (Elemental Zinc) should be used carefully in the following conditions:

• Hypercalcaemia: Vitamin D3 increases calcium absorption; use with caution in patients with elevated calcium levels.

• Hypervitaminosis A: Pre-existing toxicity or liver disease impairing vitamin A metabolism contraindicates additional supplementation.

• Renal Impairment: Impaired vitamin D activation increases hypercalcaemia risk with D3 supplementation.

• Haemochromatosis: Niacin may enhance iron absorption; caution is required in iron overload conditions.

• Epilepsy: High-dose B6 may reduce the effectiveness of certain anticonvulsant medicines.

Usually taken as a single oral dose once daily with food as directed by your doctor. Dose depends on the specific formulation, individual nutritional requirements, and clinical indication.

If a dose is missed, take it as soon as remembered. However, if it is close to the time of the next scheduled dose, skip the missed dose and resume the regular schedule. Do not double the dose to make up for a missed one.