Topiroxostat

Uses

Topiroxostat is used in the treatment of gout.

How it Works

How Topiroxostat works Gout occurs due to elevated levels of uric acid in the blood. Topiroxostat reduces the synthesis of uric acid by inhibiting the enzyme responsible for its production.

Side Effects

Common side effects of Topiroxostat include increased liver enzymes.

Expert Advice

Take adequate water or fluids while using Topiroxostat to prevent kidney stones.
Treatment with this medication should not begin during a sudden or severe gout attack.
Wait until your current gout attack has resolved before starting this medication.
Consult your doctor before taking Topiroxostat if you have or have ever had:

Kidney stones
Stomach ulcers
Peptic ulcers
Diabetes
Liver disorders
Blood disorders

Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

Other Combinations

Frequently asked questions

Is Topiroxostat safe for patients with kidney disease?

Topiroxostat should be used with caution in patients with kidney disease due to an increased risk of side effects.

What is the recommended dosage of Topiroxostat for adults?

The typical starting dose of Topiroxostat for adults is 20 mg taken orally twice daily. This may be gradually increased based on blood uric acid levels, with a usual maintenance dose of 60 mg twice daily, and adjustments up to 80 mg twice daily if necessary.

What precautions should be taken when increasing the dose of Topiroxostat?

The dosage of Topiroxostat should be increased gradually, starting at 20 mg twice daily, with potential increases to 40 mg at or after Week 2, and to 60 mg at or after Week 6, ensuring adequate patient monitoring after each increase.

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