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Tolvaptan

Uses

Tolvaptan Uses Tolvaptan is used in the treatment of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and low sodium levels in the blood. It addresses low sodium levels, which can result from conditions such as heart failure, cirrhosis, and SIADH.

How it Works

How Tolvaptan works Tolvaptan is a vasopressin antagonist. It functions by blocking the effects of the hormone vasopressin in the body. This action increases urine production, reduces the amount of water in the blood, and raises the blood sodium level.

Side Effects

Common side effects of Tolvaptan include dryness in the mouth, increased thirst, dizziness, nausea, fatigue, polyuria, and diarrhea.

Expert Advice

  • Tolvaptan treats low sodium levels in the blood.
  • It improves urine flow without causing excessive sodium loss during urination.
  • Take it at the same time every day.
  • Follow the dose and duration prescribed by your doctor.
  • To avoid dehydration, drink fluids as soon as you feel thirsty, but avoid alcoholic beverages.
  • Do not take Tolvaptan if you:
    • Are unable to urinate
    • Cannot recognize when you are thirsty
    • Are severely dehydrated
  • You will need to be hospitalized under observation whenever you start or restart treatment with Tolvaptan.
  • Inform your doctor if you notice:
    • Problems with speech or muscle control
    • Trouble swallowing
    • Trouble moving your arms and legs
    • Mood changes
  • Your doctor may check your liver function before starting treatment and regularly thereafter.
  • Inform your doctor if you notice:
    • Yellowing of the eyes or skin
    • Dark urine
    • Stomach pain

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Frequently asked questions

Tolvaptan is typically prescribed for a maximum of 30 days to correct sodium levels. Consult your doctor about stopping the medication once sodium levels normalize.
Tolvaptan should not be taken by individuals with low sodium levels, those unable to replace fluids, patients with impaired kidney function due to fluid loss, those who cannot sense thirst or dizziness, individuals allergic to Tolvaptan, or those on medications that interfere with Tolvaptan's effectiveness.
Yes, Tolvaptan may increase blood sugar levels. Patients with diabetes should monitor their blood sugar closely while taking this medication.
Seek urgent medical attention immediately if you suspect an overdose. Symptoms may include excessive thirst, dry skin, sunken eyes, rapid heartbeat, shallow breathing, low blood pressure, increased urination, and fainting.
No, grapefruit and grapefruit juice should be avoided while taking Tolvaptan, as they can increase Tolvaptan levels in the blood and cause sodium levels to rise too rapidly.
Tolvaptan can cause sodium levels in your blood to rise too quickly, potentially leading to osmotic demyelination syndrome (ODS), which may result in serious nerve damage, coma, or death. Symptoms of ODS include difficulty speaking or swallowing, drowsiness, confusion, mood changes, seizures, involuntary movements, and muscle weakness.
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