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Riluzole

Uses

Riluzole is used in the treatment of amyotrophic lateral sclerosis (ALS).

How it Works

How Riluzole works Riluzole is a glutamate antagonist and is used as an anticonvulsant. It is believed to work by inhibiting the action of glutamate, a chemical messenger, and also inactivates voltage-dependent sodium channels. In this way, it regulates the transmission of nerve signals in the brain.

Side Effects

Common side effects of Riluzole include weakness, dizziness, nausea, decreased pulmonary function, high blood pressure, tachycardia, xerostomia, and peripheral edema.

Expert Advice

  • Take it twice a day, 1 hour before or 2 hours after a meal, preferably at the same time.
  • It may cause sleepiness; avoid driving or engaging in activities that require concentration until you know how it affects you.
  • Avoid smoking, as it may reduce the effectiveness of Riluzole.
  • Your doctor may monitor your liver function, lung function, and blood count while you are taking this medication.
  • Inform your doctor if you develop any of the following symptoms while taking this medicine:
    • Yellowing of the skin
    • Abdominal pain
    • Fever
    • Sore throat
    • New cough
    • Shortness of breath
  • Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

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Frequently asked questions

Approximately 5 to 10 percent of ALS cases are familial, meaning they are inherited. Risk factors include smoking, exposure to pesticides, and military service, which may increase the risk due to exposure to toxins or physical strain.
ALS is diagnosed through a detailed history of symptoms and a physician's physical examination, along with tests such as Electromyography (EMG) and nerve conduction studies (NCS) to assess muscle and nerve electrical activity.
No, Riluzole does not cure ALS. It extends survival by delaying the progression of the disease, allowing patients to live without external breathing support.
Yes, Riluzole tablets can be crushed and mixed with a spoonful of sugar, food puree, or yogurt. However, crushed tablets may cause an anesthetic effect on the tongue. If swallowing is an issue, an oral suspension of Riluzole can be used.
No, Riluzole should not be taken with meals, as food can reduce its absorption and effectiveness. It should be taken at least 1 hour before or 2 hours after meals, and high-fat meals should be avoided.
Early symptoms of ALS include muscle twitches, cramps, stiffness, and weakness in the arms, legs, neck, or diaphragm, as well as slurred speech and difficulty chewing or swallowing. Symptoms often first appear in the hands or arms, affecting simple tasks, or in the legs, causing awkwardness while walking.
The duration of Riluzole therapy depends on your response to the treatment and tolerance. Continue taking Riluzole even if you feel well, as it may delay ALS progression but does not cure it. Consult your doctor before stopping the medication.
Taking more than the recommended dose of Riluzole may cause drowsiness, headache, tiredness, memory loss, shortness of breath, difficulty concentrating, involuntary movements, skin discoloration, seizures, or coma. Seek immediate medical help if these symptoms occur.
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