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Pyrazinamide

Uses

Pyrazinamide is used in the treatment of tuberculosis.

How it Works

How Pyrazinamide works Pyrazinamide is an antitubercular medication. In the body, it is converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I, a bacterial enzyme that is essential for bacterial growth. Therefore, it acts as a bactericidal agent to inhibit their growth and treat tuberculosis.

Side Effects

Common side effects of Pyrazinamide include hepatitis (viral infection of the liver), joint pain, nausea, vomiting, and abdominal pain.

Expert Advice

Pyrazinamide, in conjunction with other medications, effectively treats tuberculosis.
Do not forget a dose, as this increases the risk of bacteria becoming resistant to the medication and heightens the risk of side effects.
Your doctor may check your liver function before starting treatment and continue to monitor it regularly thereafter.
Inform your doctor if you notice:

Yellowing of the eyes or skin
Dark urine
Stomach pain

Avoid drinking alcohol while taking Pyrazinamide, as this may increase the risk of liver-related side effects.
Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while taking Pyrazinamide, as it may reduce the effectiveness of hormonal contraceptives like the pill.

Other Combinations

Ethambutol + Isoniazid + Piperine + Pyrazinamide + Rifampicin

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin

Isoniazid + Pyrazinamide + Rifampicin

Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Related Medications

Salt Composition

Pyrazinamide

Zin LC Tablet 10s

Abbott Healthcare Pvt. Ltd.

Strip of 10 tablets

MRP ₹32.6

Salt Composition

Pyrazinamide

Tbzide Tablet

Biochem Pharmaceutical Industries

Strip of 10 tablets

MRP ₹17.3

Salt Composition

Pyrazinamide 500mg

Pyriza 500mg Tablet 10s

Dr. Morepen Ltd.

Strip of 10 tablets

MRP ₹51.2

Salt Composition

Pyrazinamide 750mg

Eurozide 750mg Tablet

Euro Biogenics

Strip of 10 tablets

MRP ₹65

Salt Composition

Pyrazinamide 500mg

Piraldina 500mg Tablet 10s

Pharmed Ltd.

Strip of 10 tablets

MRP ₹40

Salt Composition

Pyrazinamide 750mg

Ticimide 750mg Tablet

MRP ₹64.1

Pyrazinamide 750mg

Maitri Healthcare Pvt. Ltd.

Strip of 10 tablets

MRP ₹47.5

Salt Composition

Pyrazinamide 750mg

Mecoy 750mg Tablet 10s

Orison Pharma International

Strip of 10 tablets

MRP ₹47.8

Salt Composition

Pyrazinamide 750mg

MONTOZIN 750MG TABLET

Shreya Life Sciences Pvt. Ltd.

Strip of 10 tablets

MRP ₹25.3

Salt Composition

Pyrazinamide 250mg

Piraldina 250mg Tablet 10s

Pharmed Ltd.

Strip of 10 tablets

MRP ₹17

Salt Composition

Pyrazinamide 750mg

Pyraface 750mg Tablet 10s

MRP ₹53.6

Pyrazinamide 750mg

Biocin Genetics & Pharma

MRP ₹63

Pyrazinamide 750mg

MRP ₹49.5

Pyrazinamide 750mg

Kentreck Laboratories Pvt. Ltd.

Strip of 10 tablets

MRP ₹60

Salt Composition

Pyrazinamide 500mg

Pizamax 500mg Tablet

Ind Swift Laboratories Ltd.

Strip of 10 tablets

MRP ₹27.8

Salt Composition

Pyrazinamide 750mg

PM-Zide 750mg Tablet

RK Medicare Pvt. Ltd.

Strip of 10 tablets

MRP ₹70

Salt Composition

Pyrazinamide 500mg

MONTOZIN 500MG TABLET

Shreya Life Sciences Pvt. Ltd.

Strip of 10 tablets

MRP ₹17.1

Salt Composition

Pyrazinamide 140mg

Pyramid 140mg Granules 140gm

MRP ₹54

Pyrazinamide 750mg

Zeelab Pharmacy Pvt. Ltd.

Strip of 10 tablets

MRP ₹35

Salt Composition

Pyrazinamide 1000mg

P Zide 1000 Tablet

Cadila Healthcare Ltd.

Strip of 10 tablets

MRP ₹96.9

Salt Composition

Pyrazinamide 500mg

Pzide 500mg Tablet

Cadila Healthcare Ltd.

Strip of 0 tablets

MRP ₹42.5

Salt Composition

Pyrazinamide 750mg

P Zide 750 Tablet

Cadila Healthcare Ltd.

Strip of 10 tablets

MRP ₹76.9

Salt Composition

Pyrazinamide 750mg

Pza Ciba 750mg Tablet

Novartis India Ltd.

Strip of 10 tablets

MRP ₹67.5

Salt Composition

Pyrazinamide 1500mg

Macrozide 1500 Tablet

Macleods Pharmaceuticals Pvt. Ltd.

Strip of 6 tablets

MRP ₹74.3

Salt Composition

Pyrazinamide 750mg

Mzide 750mg Tablet

Marc Laboratories Pvt. Ltd.

Strip of 10 tablets

MRP ₹60.2

Frequently asked questions

Is Pyrazinamide bactericidal?

Pyrazinamide exhibits both bacteriostatic and bactericidal properties, inhibiting bacterial growth in some cases while killing tuberculosis-causing bacteria in others.

What is Pyrazinamide and what is its use?

Pyrazinamide is an antibiotic used in combination with other antibiotics to treat tuberculosis.

How does Pyrazinamide work to treat tuberculosis?

Pyrazinamide targets Mycobacterium tuberculosis, either killing or inhibiting its growth; however, its exact mechanism of action is not fully understood.

How does Pyrazinamide lead to hyperuricemia and gout?

After oral administration, Pyrazinamide is converted to pyrazinoic acid, which inhibits urate excretion by the kidneys, leading to increased blood uric acid levels (hyperuricemia) and potentially causing gout symptoms such as joint pain and swelling.

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