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Pyrazinamide

Uses

Pyrazinamide is used in the treatment of tuberculosis.

How it Works

How Pyrazinamide works Pyrazinamide is an antitubercular medication. In the body, it is converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I, a bacterial enzyme that is essential for bacterial growth. Therefore, it acts as a bactericidal agent to inhibit their growth and treat tuberculosis.

Side Effects

Common side effects of Pyrazinamide include hepatitis (viral infection of the liver), joint pain, nausea, vomiting, and abdominal pain.

Expert Advice

Pyrazinamide, in conjunction with other medications, effectively treats tuberculosis.
Do not forget a dose, as this increases the risk of bacteria becoming resistant to the medication and heightens the risk of side effects.
Your doctor may check your liver function before starting treatment and continue to monitor it regularly thereafter.
Inform your doctor if you notice:

Yellowing of the eyes or skin
Dark urine
Stomach pain

Avoid drinking alcohol while taking Pyrazinamide, as this may increase the risk of liver-related side effects.
Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while taking Pyrazinamide, as it may reduce the effectiveness of hormonal contraceptives like the pill.

Other Combinations

Ethambutol + Isoniazid + Piperine + Pyrazinamide + Rifampicin

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Isoniazid + Pyrazinamide + Rifampicin

Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Related Medications

Salt Composition

Pyrazinamide

Tbzide Tablet

Biochem Pharmaceutical Industries

Strip of 10 tablets

MRP ₹17.3

Salt Composition

Pyrazinamide

Zin LC Tablet 10s

Abbott Healthcare Pvt. Ltd.

Strip of 10 tablets

MRP ₹32.6

Salt Composition

Pyrazinamide 750mg

Pyriza 750mg Tablet 10s

MRP ₹67.5

Pyrazinamide 750mg

MRP ₹63

Pyrazinamide 750mg

Pyrina 750mg Tablet 10s

MRP ₹60

Pyrazinamide 750mg

Ind Swift Laboratories Ltd.

Strip of 10 tablets

MRP ₹15.5

Salt Composition

Pyrazinamide 750mg

Ultimide 750mg Tablet

Concept Pharmaceuticals Ltd.

Strip of 10 tablets

MRP ₹57.5

Salt Composition

Pyrazinamide 750mg

Zed 750mg Tablet 10s

Pan Pharmaceuticals Ltd.

Strip of 10 tablets

MRP ₹20.5

Salt Composition

Pyrazinamide 750mg

Zopycox 750mg Tablet

Zorex Pharma Pvt. Ltd..

Strip of 10 tablets

MRP ₹49

Salt Composition

Pyrazinamide 1000mg

Mzide 1000mg Tablet

Marc Laboratories Pvt. Ltd.

Strip of 10 tablets

MRP ₹80.6

Salt Composition

Pyrazinamide 500mg

Pyzox 500mg Tablet 10s

Chemo Healthcare Pvt. Ltd.

Strip of 10 tablets

MRP ₹945.2

Salt Composition

Pyrazinamide 500mg

Zin 500mg Tablet 10s

Radicura Pharma Pvt. Ltd.

Strip of 10 tablets

MRP ₹41

Salt Composition

Pyrazinamide 500mg

Ticimide 500mg Tablet

MRP ₹40.8

Pyrazinamide 750mg

Hamax Pharmaceuticals

MRP ₹60

Pyrazinamide 1000mg

MRP ₹75

Pyrazinamide 1000mg

PM-Zide 1000mg Tablet

RK Medicare Pvt. Ltd.

Strip of 10 tablets

MRP ₹99

Salt Composition

Pyrazinamide 750mg

Toszinamide Forte Tablet

TOSC International Pvt. Ltd.

Strip of 10 tablets

MRP ₹63

Salt Composition

Pyrazinamide 500mg

P Zide 500 Tablet 20 Tablet

Cadila Healthcare Ltd.

Strip of 20 tablets

MRP ₹88

Salt Composition

Pyrazinamide 750mg

Cavizide 750mg Tablet 10s

MRP ₹46

Pyrazinamide 750mg

Brilliant Lifesciences Pvt. Ltd.

MRP ₹72

Pyrazinamide 500mg

MRP ₹18

Pyrazinamide 500mg

Pza Ciba 500mg Tablet 1 Tablet

Novartis India Ltd.

Strip of 1 tablets

MRP ₹6.1

Salt Composition

Pyrazinamide 500mg

Pza Ciba 500mg Tablet 10 Tablet

MRP ₹42.5

Pyrazinamide 1000mg

MRP ₹112.4

Pyrazinamide 750mg

Zydus Healthcare Ltd.

Strip of 10 tablets

MRP ₹23.8

Frequently asked questions

Is Pyrazinamide bactericidal?

Pyrazinamide exhibits both bacteriostatic and bactericidal properties, inhibiting bacterial growth in some cases while killing tuberculosis-causing bacteria in others.

What is Pyrazinamide and what is its use?

Pyrazinamide is an antibiotic used in combination with other antibiotics to treat tuberculosis.

How does Pyrazinamide work to treat tuberculosis?

Pyrazinamide targets Mycobacterium tuberculosis, either killing or inhibiting its growth; however, its exact mechanism of action is not fully understood.

How does Pyrazinamide lead to hyperuricemia and gout?

After oral administration, Pyrazinamide is converted to pyrazinoic acid, which inhibits urate excretion by the kidneys, leading to increased blood uric acid levels (hyperuricemia) and potentially causing gout symptoms such as joint pain and swelling.