Pyrazinamide

Uses

Pyrazinamide is used in the treatment of tuberculosis.

How it Works

How Pyrazinamide works Pyrazinamide is an antitubercular medication. In the body, it is converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I, a bacterial enzyme that is essential for bacterial growth. Therefore, it acts as a bactericidal agent to inhibit their growth and treat tuberculosis.

Side Effects

Common side effects of Pyrazinamide include hepatitis (viral infection of the liver), joint pain, nausea, vomiting, and abdominal pain.

Expert Advice

Pyrazinamide, in conjunction with other medications, effectively treats tuberculosis.
Do not forget a dose, as this increases the risk of bacteria becoming resistant to the medication and heightens the risk of side effects.
Your doctor may check your liver function before starting treatment and continue to monitor it regularly thereafter.
Inform your doctor if you notice:

Yellowing of the eyes or skin
Dark urine
Stomach pain

Avoid drinking alcohol while taking Pyrazinamide, as this may increase the risk of liver-related side effects.
Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while taking Pyrazinamide, as it may reduce the effectiveness of hormonal contraceptives like the pill.

Other Combinations

Ethambutol + Isoniazid + Piperine + Pyrazinamide + Rifampicin

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin

Isoniazid + Pyrazinamide + Rifampicin

Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Frequently asked questions

Is Pyrazinamide bactericidal?

Pyrazinamide exhibits both bacteriostatic and bactericidal properties, inhibiting bacterial growth in some cases while killing tuberculosis-causing bacteria in others.

What is Pyrazinamide and what is its use?

Pyrazinamide is an antibiotic used in combination with other antibiotics to treat tuberculosis.

How does Pyrazinamide work to treat tuberculosis?

Pyrazinamide targets Mycobacterium tuberculosis, either killing or inhibiting its growth; however, its exact mechanism of action is not fully understood.

How does Pyrazinamide lead to hyperuricemia and gout?

After oral administration, Pyrazinamide is converted to pyrazinoic acid, which inhibits urate excretion by the kidneys, leading to increased blood uric acid levels (hyperuricemia) and potentially causing gout symptoms such as joint pain and swelling.

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