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Promethazine is used in the treatment of nausea, vomiting, vertigo, allergic conditions, as an appetite stimulant, for morning sickness, and for motion sickness. It is also used for the short-term treatment of insomnia (difficulty sleeping) in adults and as a sedative in children aged 5 years and older.
How Promethazine works Promethazine is an antiallergic medication. When your body is exposed to an allergen such as pollen, animal dander, or house dust, it produces a chemical called histamine. This leads to symptoms like watery eyes, a runny or blocked nose, sneezing, skin rashes, and itching. Promethazine works by blocking the action of histamine, thereby alleviating these symptoms. Additionally, it acts on various areas of the brain to prevent nausea and vomiting, helping you feel more relaxed.