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Probenecid

Uses

Probenecid is used in the treatment of gout.

How it Works

How Probenecid Works Probenecid is a urine alkalizer. It functions by increasing the pH of urine, making it less acidic. This process aids the kidneys in eliminating excess uric acid, thereby preventing gout and certain types of kidney stones.

Side Effects

Common side effects of Probenecid include nausea, vomiting, headache, gout flares, fever, rash, aplastic anemia, hemolytic anemia, and decreased white blood cell count (lymphocytes).

Expert Advice

  • Do not use probenecid along with salicylates, such as aspirin.
  • You may be prescribed colchicine or a non-steroidal anti-inflammatory agent (NSAID, pain killer) to prevent severe gouty attacks during the first 6 to 12 months of probenecid therapy.
  • Consult your doctor before starting probenecid treatment if you have or have ever had:
    • Kidney stones
    • Any other kidney disorder
    • Ulcers in the stomach and small intestine (peptic ulcers)
    • Diabetes
    • Severe liver disorders
    • Blood disorders
    • Glucose 6-phosphate dehydrogenase (G6PD) deficiency
  • Inform your doctor about any scheduled surgery for which you will be receiving anesthetics.
  • You should consume adequate water or fluids while taking probenecid to prevent kidney stones.
  • Notify your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.
  • Take precautions while driving or operating machinery, as probenecid is known to cause dizziness.

Other Combinations

Cefalexin + Probenecid

Cefadroxil + Probenecid

Ampicillin + Probenecid

Amoxycillin + Cloxacillin + Probenecid

Amoxycillin + Probenecid

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Frequently asked questions

Probenecid is a uricosuric agent used to lower uric acid levels and to prevent and treat gout and gouty arthritis. It is also used to enhance the effectiveness of antibiotics like penicillin.
Yes, kidney stones are a known side effect of probenecid treatment.
Probenecid is prescribed with penicillin in certain serious infections to prolong the antibiotic's effect. It works by inhibiting the kidney's elimination of penicillin, increasing its concentration in the blood.
No, probenecid is a uricosuric agent used to lower uric acid levels and treat gout. It does not have anti-inflammatory properties like NSAIDs, nor does it fight infections like antibiotics or sulfa drugs. It is sometimes used with antibiotics to enhance their effect but is not a diuretic.
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