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Pertuzumab + Trastuzumab

Uses

Pertuzumab and Trastuzumab are used in the treatment of breast cancer.

How it Works

How Pertuzumab and Trastuzumab Work Pertuzumab and Trastuzumab is a combination of two anticancer medications. Pertuzumab recognizes and attaches to a protein called human epidermal growth factor 2 (HER2), which is abundantly present on the surface of certain cancer cells and stimulates their growth. When Pertuzumab attaches to HER2 on cancer cells, it may slow or stop their growth or even kill them. Trastuzumab also binds to HER2, inhibiting the growth of cancer cells and leading to their death.

Side Effects

Common side effects of Pertuzumab and Trastuzumab include hair loss, nausea, diarrhea, joint pain, and fatigue.

Expert Advice

  • Do not receive any kind of immunization or vaccination without your doctor’s approval while taking Pertuzumab + Trastuzumab.
  • Use contraceptives, and do not conceive a child (get pregnant) while taking Pertuzumab + Trastuzumab.
  • Barrier methods of contraception, such as condoms, are recommended.
  • Drink at least two to three quarts of fluid every 24 hours, unless instructed otherwise.
  • You may be at risk of infection; try to avoid crowds or people with colds.
  • Report fever or any other signs of infection immediately to your healthcare provider.
  • To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
  • Take anti-diarrhea medication as prescribed by your doctor and consume foods that may help control diarrhea.
  • Avoid sun exposure; wear SPF 15 (or higher) sunblock and protective clothing.

Other Combinations

Related Medications

Frequently asked questions

Can Pertuzumab and Trastuzumab cause diarrhea?
Yes, severe diarrhea is a possible side effect of Pertuzumab and Trastuzumab, particularly in patients over 65. If severe diarrhea occurs, your doctor may prescribe medication to manage it or pause treatment until it resolves.
How is Pertuzumab and Trastuzumab administered?
Pertuzumab and Trastuzumab are given as subcutaneous injections by a healthcare professional in a hospital or clinic, typically every three weeks. Injections alternate between thighs, with each injection site being at least 2.5 cm from the previous one and free of redness, bruising, tenderness, or hardness.
Can Pertuzumab and Trastuzumab cause joint pain?
Joint pain may occur for a few days after treatment. Inform your doctor, who may prescribe pain relief. Avoid over-the-counter painkillers without consulting your doctor. To relieve joint pain, consider using a heating pad, taking warm baths, and scheduling regular rest periods.
Does Pertuzumab and Trastuzumab lead to hair loss?
Yes, hair may become brittle and break, with possible patchy hair loss or thinning during treatment. These effects typically resolve after stopping the medication. Handle hair gently during washing and brushing.
How can I improve changes in my taste during treatment?
If you experience a metallic taste or loss of taste, rinse your mouth with a salt and bicarbonate solution before meals to neutralize unpleasant flavors. Adding extra seasonings to your food may also help.
What is the dosage regimen for Pertuzumab and Trastuzumab?
Pertuzumab and Trastuzumab are administered as a loading dose followed by maintenance doses. The loading dose is a larger amount given once over 8 minutes, while subsequent maintenance doses are smaller and given over 5 minutes.
How can I determine if Pertuzumab and Trastuzumab is effective?
Continue taking the medication as prescribed until your doctor advises otherwise. Regular scans will assess the tumor's response to treatment, and your doctor will schedule these evaluations.
Is it safe to take Pertuzumab and Trastuzumab during pregnancy?
This treatment can harm a developing fetus. It is crucial to avoid pregnancy or fathering a child during treatment and for at least 7 months afterward. Discuss effective contraception with your doctor before starting treatment.
How can I manage diarrhea while receiving Pertuzumab and Trastuzumab?
To alleviate diarrhea, consume foods high in soluble fiber, such as ripe bananas, oranges, boiled potatoes, white rice, curd, and oatmeal. Stay hydrated by drinking 8-10 glasses of water daily and consider soups and juices for additional hydration.
Could nausea and fatigue be side effects of Pertuzumab and Trastuzumab?
Yes, nausea and fatigue are common side effects. To reduce nausea, eat smaller, more frequent meals and avoid salty, spicy, fried, or fatty foods. Ensure you get plenty of rest and incorporate light exercise to combat fatigue.
What can I do to relieve constipation while on Pertuzumab and Trastuzumab?
To alleviate constipation, increase dietary fiber intake (fruits and vegetables), drink 8-10 glasses of fluids daily, and stay active. A stool softener may be recommended by your doctor. Consult your doctor if you haven't had a bowel movement in 2-3 days.
Are there any dietary restrictions while taking Pertuzumab and Trastuzumab?
You can maintain your usual diet unless advised otherwise by your doctor. It is recommended to sip water regularly, eat small nourishing snacks frequently, and suck on hard candy or popsicles to help prevent nausea and vomiting.
What information should I provide to my doctor before receiving Pertuzumab and Trastuzumab?
Inform your doctor about any allergies to medications, heart issues, current infections, fever, or diarrhea prior to receiving Pertuzumab and Trastuzumab.
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