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Pamidronate

Uses

Pamidronate is used in the treatment of high calcium levels in the blood and osteoporosis.

How it Works

How Pamidronate works Pamidronate is a bisphosphonate that functions by suppressing the activity of osteoclasts, the cells responsible for bone destruction. This action strengthens the bones and minimizes the risk of fractures.

Side Effects

Common side effects of Pamidronate include headache, diarrhea, low blood platelets, joint pain, muscle pain, vomiting, conjunctivitis, nausea, decreased potassium levels in the blood, abdominal pain, loss of appetite, decreased phosphate levels in the blood, decreased calcium levels in the blood, fever, anemia (low number of red blood cells), atrial fibrillation, decreased magnesium levels in the blood, high blood pressure, bone pain, constipation, flu-like symptoms, tiredness, lymphocytopenia, granulocytopenia, sleep disturbances, skin rash, generalized pain, hydronephrosis, and infusion site reactions.

Expert Advice

  • Your doctor has prescribed Pamidronate to strengthen your bones and reduce the risk of fractures.
  • Take it in the morning at least 30 minutes before eating or drinking anything.
  • Maintain an upright posture for 30 minutes after taking the medication to prevent irritation of your esophagus.
  • It may cause a decrease in the level of calcium in your blood.
  • Include calcium-rich foods in your diet and have regular blood tests to monitor your calcium levels.
  • It is important to care for your mouth and teeth while on this medication.
  • Schedule regular dental check-ups and inform your dentist that you are taking Pamidronate.
  • Pamidronate is administered by injection into a vein, typically over at least 15 minutes or as directed by your doctor.
  • Drink plenty of fluids to prevent dehydration and kidney damage.
  • Calcium and vitamin D supplements may be necessary as recommended by your doctor.
  • You may experience fever or flu-like symptoms, such as chills, tiredness, and weakness; these are usually temporary and should resolve in a few days.
  • You may take a pain reliever or fever reducer to alleviate these symptoms.
  • Pamidronate may cause a rare condition known as osteonecrosis of the jaw.
  • Have regular dental check-ups and inform your doctor if you experience sudden jaw pain.
  • Your doctor will monitor your response to Pamidronate by testing your bone mineral density (BMD), typically every 1-3 years.
  • Do not take Pamidronate if you are pregnant or breastfeeding.

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Frequently asked questions

Pamidronate is safe when taken as prescribed by your doctor. Adhere strictly to the dosage instructions and report any concerning side effects.
Pamidronate is administered as a 1-2 hour intravenous infusion under medical supervision. The dosage is determined by your doctor based on your condition.
Hair loss can occur with Pamidronate, though it is not common. Report any hair loss to your doctor for further guidance.
Pamidronate prevents bone breakdown by inhibiting increased bone turnover, thereby alleviating pain and discomfort associated with conditions like bone stress and marrow edema.
Pamidronate is not considered safe during pregnancy or breastfeeding. Consult your doctor before use, as it may pose risks to the baby. Women are advised to avoid pregnancy for 6 months after treatment due to the drug's prolonged presence in bones.
The frequency of Pamidronate doses varies based on your condition, but typically ranges from 1 to 3 doses, as determined by your doctor.
To enhance the benefits of Pamidronate, incorporate calcium and vitamin D-rich foods, increase sun exposure for natural vitamin D, quit smoking, limit alcohol, and engage in weight-bearing exercises like walking and strength training.
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