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OnabotulinumtoxinA

Uses

OnabotulinumtoxinA Uses OnabotulinumtoxinA is used in the treatment of botulism, overactive bladder (OAB) symptoms, wrinkles, prevention of migraines, muscle spasms, cervical dystonia, and strabismus. It is also used to treat muscle stiffness in the elbow, wrist, fingers, ankle, and toe muscles in adults. Additionally, it reduces the symptoms of severe underarm sweating.

How it Works

How OnabotulinumtoxinA works: OnabotulinumtoxinA is a protein produced by a type of bacteria called Clostridium botulinum type A. It functions by blocking the release of a chemical known as acetylcholine. This action temporarily weakens nerve activity in the muscles surrounding the bladder, alleviating symptoms such as urinary urgency and frequency. Additionally, it blocks pain signals associated with migraines and treats various types of involuntary muscle contractions.

Side Effects

Common side effects of OnabotulinumtoxinA include dryness in the mouth, neck pain, injection site pain, tiredness, and headache.

Expert Advice

  • OnabotulinumtoxinA prevents headaches in individuals with chronic migraines and treats various other conditions, including muscle spasms and wrinkles.
  • It can prevent migraines before they even begin.
  • Your doctor will administer multiple injections at different sites, depending on your specific condition.
  • Potential side effects include swallowing, speaking, or breathing difficulties.
  • Inform your doctor if you experience:
    • Trouble swallowing
    • Slurred speech
    • Loss of bladder control
    • Muscle weakness
    • Breathing difficulties
  • Dizziness may occur; avoid driving or engaging in activities requiring concentration until you understand how it affects you.

Other Combinations

Related Medications

Frequently asked questions

Can OnabotulinumtoxinA exacerbate migraines?
No, OnabotulinumtoxinA is utilized to prevent chronic migraines in adults, particularly those experiencing headaches 15 or more days a month lasting 4 or more hours.
Is OnabotulinumtoxinA detectable in the blood?
No, OnabotulinumtoxinA cannot be detected in peripheral blood after intramuscular injection at recommended doses.
Is OnabotulinumtoxinA suitable for cosmetic use?
Yes, OnabotulinumtoxinA is approved for cosmetic purposes in adults 18 years and older, including the temporary smoothing of frown lines, crow's feet, and forehead lines.
Can OnabotulinumtoxinA be used for overactive bladder?
Yes, OnabotulinumtoxinA is indicated for overactive bladder, a condition characterized by uncontrollable bladder contractions leading to frequent urination, especially in adults when other treatments have failed.
What are the storage guidelines for OnabotulinumtoxinA?
Unopened vials should be refrigerated at 2° to 8°C (36°F to 46°F) for up to 3 years. Once reconstituted, it should be used within 24 hours and stored in the refrigerator.
Can OnabotulinumtoxinA be used for lower limb spasticity?
Yes, OnabotulinumtoxinA is effective in treating lower limb spasticity in adults, helping to reduce stiffness and increased muscle tone in the ankle and toe.
What is the recommended duration for taking OnabotulinumtoxinA?
The duration of treatment varies based on the condition being treated. Typically, it is administered as a one-time injection, with potential repeat doses every 3 to 6-7 months as directed by a doctor.
When can I expect to see improvements after receiving OnabotulinumtoxinA?
Improvements typically begin within two weeks, with maximum benefits observed around six weeks post-injection. Consult your doctor for specific expectations, and report any lack of improvement.
What information should I provide my doctor before taking OnabotulinumtoxinA?
Inform your doctor about all medical conditions, particularly those affecting muscles and nerves, allergies to botulinum toxins, breathing or swallowing issues, recent facial surgeries, and if you are pregnant, planning to become pregnant, or breastfeeding. Symptoms of urinary tract infections should also be reported.
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