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Nortriptyline + Pregabalin

Uses

Pregabalin and Nortriptyline are used in the treatment of neuropathic pain.

How it Works

How Pregabalin and Nortriptyline Work Pregabalin and Nortriptyline is a combination of two medications: Pregabalin and Nortriptyline. Pregabalin is an alpha-2 delta ligand that decreases pain by modulating the calcium channel activity of nerve cells. Nortriptyline is a tricyclic antidepressant that increases the levels of chemical messengers (serotonin and noradrenaline) that inhibit the transmission of pain signals in the brain. Together, they effectively relieve neuropathic pain, which is pain resulting from damaged nerves.

Side Effects

Common side effects of Pregabalin and Nortriptyline include constipation, difficulty urinating, weight gain, sleepiness, dizziness, tiredness, blurred vision, dry mouth, increased heart rate, orthostatic hypotension (sudden lowering of blood pressure upon standing), and uncoordinated body movements.

Expert Advice

  • Pregabalin + Nortriptyline is used to treat certain types of chronic pain caused by nerve damage.
  • Inform your doctor if you are taking any other pain-relieving medications.
  • Notify your doctor if you have a history of seizures.
  • Immediately seek medical assistance if you experience:
    • Hallucinations
    • Fever
    • Sweating
    • Shivering
    • Fast heart rate
    • Muscle twitching
    • Loss of coordination
  • Along with taking Pregabalin + Nortriptyline, your doctor may recommend physiotherapy to help relieve pain.

Other Combinations

Nortriptyline + Pregabalin + Vitamin B12 (Methylcobalamin)

Gabapentin + Nortriptyline + Vitamin B12 (Methylcobalamin)

Frequently asked questions

Pregabalin+Nortriptyline is a combination of two medications used to treat nerve pain (neuropathic pain) by calming damaged or overactive nerves, thereby reducing pain sensation.
Regular check-ups are recommended after starting Pregabalin+Nortriptyline, especially if symptoms do not improve or side effects persist.
Contact your doctor or seek emergency help immediately, even if there are no symptoms, as overdose can lead to serious complications.
If you miss a dose and it's almost time for the next one, skip the missed dose. Otherwise, take it as soon as you remember, but do not double up on doses.
Initial benefits may be seen after 2 weeks, but full effects can take 2-3 months or longer.
Yes, it may affect sexual function in both men and women, causing decreased desire, erectile dysfunction, and reduced satisfaction. Discuss any concerns with your doctor without stopping the medication.
No, you should not stop taking Pregabalin+Nortriptyline even if your pain improves. Consult your doctor before discontinuing, as sudden cessation may lead to withdrawal symptoms.
Yes, Pregabalin+Nortriptyline may cause drowsiness or sudden sleep episodes. Avoid driving or operating machinery until you know how it affects you, and inform your doctor if these episodes occur.
Avoid alcohol, grapefruit, and activities requiring alertness due to potential impairment. Protect yourself from sun exposure as the medication may increase sunburn risk.
To manage potential weight gain, maintain a healthy, balanced diet without increasing portion sizes, avoid high-calorie foods, and engage in regular exercise.
Serious side effects are rare but may include changes in body temperature, difficulty breathing, increased heartbeat, mood changes, and signs of infection. Seek medical attention if these occur.
Store tablets in their original packaging in a cool, dry place, out of children's reach. Dispose of unused medications safely to prevent accidental consumption.
No, taking a higher dose may not enhance effectiveness and can increase the risk of serious side effects. Consult your doctor for dosage adjustments if needed.
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