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Methotrexate

Uses

Methotrexate is used in the treatment of rheumatoid arthritis and psoriasis.

How it Works

How Methotrexate Works Methotrexate is an immunosuppressant. In rheumatoid arthritis, it reduces the activity of the body's immune system, which decreases swelling, alleviates pain and stiffness, and improves function. In psoriasis, it slows down the rapid growth of skin cells.

Side Effects

Common side effects of Methotrexate include abdominal pain, loss of appetite, nausea, vomiting, increased liver enzymes, stomatitis (inflammation of the mouth), low blood platelets, headache, mouth ulcers, decreased white blood cell count, fatigue, diarrhea, drowsiness, throat ulcers, dyspepsia, anemia (low number of red blood cells), pneumonitis, exanthema, erythema (skin redness), and itching.

Expert Advice

Take it once a week, on the same day every week.
Drink plenty of liquids to stay hydrated while taking this medication.
Always take folic acid as advised by your doctor; this will help lessen the side effects of this medicine.
It may take 6 to 8 weeks for Methotrexate to take effect.
Continue taking the medication as prescribed.
Avoid drinking alcohol while taking this medicine, as it may increase the risk of side effects.
This medication can be harmful to an unborn baby; avoid pregnancy for at least 6 months after your last dose.

Other Combinations

Methotrexate + Vitamin B9 (Folic Acid)

Related Medications

Salt Composition in both

Methotrexate 1000mg

Methocel 1000mg Injection

Celon Laboratories Ltd.

₹904.8

Merex 1000mg Injection 10ml

Intas Pharmaceuticals Ltd.

₹1,044.1

MRP ₹2,088.3

Salt Composition in both

Methotrexate 1000mg

Merex 1000mg Injection 40ml

Intas Pharmaceuticals Ltd.

₹2,025.2

Merex 1000mg Injection 10ml

Intas Pharmaceuticals Ltd.

₹1,044.1

MRP ₹2,088.3

Salt Composition in both

Methotrexate 15mg

Imutaj 15mg Injection

Taj Pharma India Ltd.

₹117

Folitrax 15mg Injection 1ml

Ipca Laboratories Ltd.

Ampoule of 1 ml

₹76.8

MRP ₹93.7

Salt Composition

Methotrexate 15mg

Folitrax 15mg Injection 1ml

Ipca Laboratories Ltd.

Ampoule of 1 ml

₹76.8

MRP ₹93.7

Salt Composition in both

Methotrexate 5mg

Nanotrax 5mg Tablet 10s

Future Pharma Pvt. Ltd.

Strip of 10 tablets

₹85

Methoquest 5mg Tablet 10s

Dr. Morepen Ltd.

₹49.5

MRP ₹99

Salt Composition in both

Methotrexate 5mg

Arthrate 5mg Tablet 10 tablets

Tas Med India Pvt. Ltd.

Strip of 10 tablets

₹112

Methoquest 5mg Tablet 10s

Dr. Morepen Ltd.

₹49.5

MRP ₹99

Salt Composition in both

Methotrexate 10mg

RA Mex 10mg Tablet

Sun Pharmaceutical Industries Ltd.

Strip of 10 tablets

₹150

Noltrexate 10mg Tablet 10s

Knoll Pharmaceuticals Ltd.

Strip of 10 tablets

₹65.2

MRP ₹130.3

Salt Composition in both

Methotrexate 10mg

Folitrax 10mg Tablet 10s

Ipca Laboratories Ltd.

Strip of 10 tablets

₹130.7

Noltrexate 10mg Tablet 10s

Knoll Pharmaceuticals Ltd.

Strip of 10 tablets

₹65.2

MRP ₹130.3

Salt Composition

Methotrexate 25mg

Folitrax 25mg Injection 1ml

Ipca Laboratories Ltd.

₹55.6

MRP ₹67.8

Salt Composition in both

Methotrexate 25mg

Folitrax 25mg Tablet 4s

Ipca Laboratories Ltd.

Strip of 4 tablets

₹287.8

Folitrax 25mg Tablet 5s

Ipca Laboratories Ltd.

Strip of 5 tablets

₹371.4

MRP ₹422

Salt Composition in both

Methotrexate 500mg

Methoget 500mg Injection 1s

GLS Pharma Ltd.

₹300

Plastomet Injection 5ml

Khandelwal Laboratories Pvt. Ltd.

₹753.8

MRP ₹1,005

Salt Composition

Methotrexate 7.5mg

Metrotrex 7.5mg Tablet 10s

Steris Healthcare Pvt. Ltd.

Strip of 10 tablets

₹55.8

MRP ₹111.5

Salt Composition in both

Methotrexate 15mg

Methofast 15mg Injection

Neon Laboratories Ltd.

₹52.9

Folitrax 15mg Injection 1ml

Ipca Laboratories Ltd.

Ampoule of 1 ml

₹76.8

MRP ₹93.7

Salt Composition

Methotrexate 7.5mg

Folitrax 7.5mg Injection 1ml

Ipca Laboratories Ltd.

₹44.9

MRP ₹51.1

Salt Composition in both

Methotrexate 50mg

Methofast 50mg Injection

Neon Laboratories Ltd.

₹59

Folitrax 50mg Injection 2ml

Ipca Laboratories Ltd.

₹122.2

MRP ₹149

Salt Composition in both

Methotrexate 50mg

Methoget 50mg Injection 1s

GLS Pharma Ltd.

₹80

Folitrax 50mg Injection 2ml

Ipca Laboratories Ltd.

₹122.2

MRP ₹149

Salt Composition in both

Methotrexate 50mg

Methocel 50mg Injection

Celon Laboratories Ltd.

₹74

Folitrax 50mg Injection 2ml

Ipca Laboratories Ltd.

₹122.2

MRP ₹149

Salt Composition in both

Methotrexate 50mg

Methocip 50mg Injection

₹48.8

Folitrax 50mg Injection 2ml

Ipca Laboratories Ltd.

₹122.2

MRP ₹149

Salt Composition in both

Methotrexate 50mg

Zuvitrex 50mg Injection

Zuvius Life Sciences

₹120

Folitrax 50mg Injection 2ml

Ipca Laboratories Ltd.

₹122.2

MRP ₹149

Salt Composition in both

Methotrexate 50mg

Remtrex 50mg Injection

Alkem Laboratories Ltd.

₹72.7

Folitrax 50mg Injection 2ml

Ipca Laboratories Ltd.

₹122.2

MRP ₹149

Salt Composition

Methotrexate 15mg

Metrotrex 15mg Tablet 10s

Steris Healthcare Pvt. Ltd.

Strip of 10 tablets

₹93

MRP ₹155

Salt Composition

Methotrexate 5mg

Noltrexate 5mg Tablet 10s

Knoll Pharmaceuticals Ltd.

Strip of 10 tablets

₹66.7

MRP ₹92.6

Salt Composition in both

Methotrexate 10mg

Mexate 10mg Tablet 10s

Strip of 10 tablets

₹139.5

Noltrexate 10mg Tablet 10s

Knoll Pharmaceuticals Ltd.

Strip of 10 tablets

₹65.2

MRP ₹130.3

Salt Composition

Methotrexate

Chicky Pharma Pvt. Ltd.

Strip of 10 tablets

₹14.6

Sorry, the substitute medicine is Currently Unavailable

Salt Composition

Methotrexate

St. George’s Methotrexate Dilution 30

St. George's Homoeopathy

Bottle of 30 ml

₹131

Sorry, the substitute medicine is Currently Unavailable

Frequently asked questions

Can Methotrexate affect fertility?

Yes, Methotrexate can impact fertility in both genders, potentially reducing sperm count in males and causing menstrual irregularities in females. These effects are typically reversible after discontinuing therapy.

Can Methotrexate cause mouth ulcers?

Yes, Methotrexate can cause mouth soreness and ulcers as side effects. Taking folic acid may help reduce these ulcers. Consult your doctor about possibly reducing the dose to further alleviate this issue.

Why do I have to take folic acid with Methotrexate?

Folic acid is essential for cell production, and Methotrexate can lower folic acid levels in the body. It helps mitigate common side effects of Methotrexate, including mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia, and liver issues.

Can Methotrexate use make me more prone to infections?

Methotrexate may suppress immune system activity, increasing the risk of serious infections, including rare lung infections. Use Methotrexate with caution if you have an active infection.

Why do I need to take regular blood tests while taking Methotrexate?

Regular blood tests allow your doctor to monitor your response to Methotrexate and check for side effects, including liver function and blood cell counts. Additional tests may be ordered based on results.

What to do if I am planning to become pregnant and my husband is taking Methotrexate?

Avoid pregnancy while your husband is on Methotrexate and for at least 3 months after therapy, as it may cause serious fetal abnormalities.

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