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Methotrexate

Uses

Methotrexate is used in the treatment of rheumatoid arthritis and psoriasis.

How it Works

How Methotrexate Works Methotrexate is an immunosuppressant. In rheumatoid arthritis, it reduces the activity of the body's immune system, which decreases swelling, alleviates pain and stiffness, and improves function. In psoriasis, it slows down the rapid growth of skin cells.

Side Effects

Common side effects of Methotrexate include abdominal pain, loss of appetite, nausea, vomiting, increased liver enzymes, stomatitis (inflammation of the mouth), low blood platelets, headache, mouth ulcers, decreased white blood cell count, fatigue, diarrhea, drowsiness, throat ulcers, dyspepsia, anemia (low number of red blood cells), pneumonitis, exanthema, erythema (skin redness), and itching.

Expert Advice

  • Take it once a week, on the same day every week.
  • Drink plenty of liquids to stay hydrated while taking this medication.
  • Always take folic acid as advised by your doctor; this will help lessen the side effects of this medicine.
  • It may take 6 to 8 weeks for Methotrexate to take effect.
  • Continue taking the medication as prescribed.
  • Avoid drinking alcohol while taking this medicine, as it may increase the risk of side effects.
  • This medication can be harmful to an unborn baby; avoid pregnancy for at least 6 months after your last dose.

Other Combinations

Methotrexate + Vitamin B9 (Folic Acid)

Frequently asked questions

Yes, Methotrexate can impact fertility in both genders, potentially reducing sperm count in males and causing menstrual irregularities in females. These effects are typically reversible after discontinuing therapy.
Yes, Methotrexate can cause mouth soreness and ulcers as side effects. Taking folic acid may help reduce these ulcers. Consult your doctor about possibly reducing the dose to further alleviate this issue.
Folic acid is essential for cell production, and Methotrexate can lower folic acid levels in the body. It helps mitigate common side effects of Methotrexate, including mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia, and liver issues.
Methotrexate may suppress immune system activity, increasing the risk of serious infections, including rare lung infections. Use Methotrexate with caution if you have an active infection.
Regular blood tests allow your doctor to monitor your response to Methotrexate and check for side effects, including liver function and blood cell counts. Additional tests may be ordered based on results.
Avoid pregnancy while your husband is on Methotrexate and for at least 3 months after therapy, as it may cause serious fetal abnormalities.
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