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Messenger ribonucleic acid (mR) (nucleoside modified)

Uses

Messenger ribonucleic acid (mRNA) (nucleoside modified) is used to prevent coronavirus disease (COVID-19).

How it Works

How messenger ribonucleic acid (mRNA) (nucleoside modified) works Messenger ribonucleic acid (mRNA) (nucleoside modified) contains the genetic material of the virus, known as mRNA, encapsulated in a lipid layer. Once the vaccine is administered, this lipid layer facilitates the delivery of the genetic code into the host cells of the vaccinated individual. The mRNA cannot replicate or cause disease. However, the immune system recognizes it as a foreign substance and is prompted to produce antibodies against this mRNA. This process enables the immune system to develop robust antibodies that can neutralize the actual virus if the individual is later exposed to it. This approach is safe for the body, provides maximum protection, and does not induce disease.

Side Effects

Common side effects of messenger ribonucleic acid (mRNA) (nucleoside modified) include injection site reactions (pain, swelling, redness), fatigue, headache, muscle pain, joint pain, chills, nausea, vomiting, swelling of lymph nodes, and fever.

Expert Advice

  • Messenger ribonucleic acid (mRNA) (nucleoside modified) is a 2-dose vaccination regimen.
  • The second dose is administered 28 days after the first dose.
  • The vaccine is given intramuscularly in the upper arm.
  • Post-vaccination, you may be observed for 15-30 minutes to monitor for any allergic reactions.
  • Getting vaccinated is voluntary; however, it is advisable to complete the vaccination schedule to help restrict the spread of the virus.
  • In addition to vaccination, observe other control measures such as:
    • Social distancing
    • Mask wearing
    • Hand washing
  • Messenger ribonucleic acid (mRNA) (nucleoside modified) is currently not recommended for children, as safety and efficacy have not yet been established.

Other Combinations

Related Medications

Frequently asked questions

Vaccines do not provide 100% protection against COVID-19. However, vaccinated individuals generally face a lower risk of severe infection compared to unvaccinated individuals. It’s important to continue taking precautions.
The safety and effectiveness of mRNA (nucleoside modified) vaccines have not been established in children. Current guidelines recommend vaccination only for individuals aged 18 and older until more data becomes available.
mRNA vaccines can be refrigerated at 2° to 8°C (36° to 46°F) for up to 30 days before first use. After administration, the vial should be kept at 2° to 25°C (36° to 77°F), and any leftover vaccine must be discarded within 12 hours.
Five vaccines granted emergency use authorization by the Drug Controller General of India are Covishield, Covaxin, Sputnik V, Moderna, and Johnson & Johnson's single-dose vaccine.
Yes, those who have had a prior COVID-19 infection should still get vaccinated, as the vaccine enhances immune response and helps prevent reinfection.
Yes, severe allergic reactions (anaphylaxis) have occurred in some individuals. Those who experience an immediate severe allergic reaction after the first dose should not receive additional doses. Additionally, myocarditis and pericarditis have been reported, particularly after the second dose. Consult your doctor if you have concerns.
Common side effects include pain or swelling at the injection site, fatigue, headache, muscle pain, chills, nausea, and fever. These are typically mild and resolve over time. Consult your doctor if they persist.
Yes, both doses are crucial for achieving full protection, which is expected two weeks after the second dose.
Current evidence suggests that newer COVID-19 strains do not affect the safety or effectiveness of mRNA (nucleoside modified) vaccines, indicating potential protection against these variants. Ongoing studies are expected to provide more data.
If the second dose is missed, the interval can be extended up to 42 days without needing to repeat the vaccination series, even if more than 42 days pass.
Inform your doctor about any regular medications, history of myocarditis or pericarditis, allergies, fever, bleeding disorders, blood thinners, immunocompromised status, or if you are pregnant or breastfeeding. Also, mention if you have received another COVID-19 vaccine.
Currently, no booster dose is required after the two-dose regimen. A third booster may be introduced later, but the two-dose schedule is being followed worldwide for now.
Yes, mRNA vaccines are safe for individuals with controlled hypertension, diabetes, and other stable medical conditions. Consult your doctor if your blood pressure or blood sugar is not well controlled before vaccination.
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