Mefenamic Acid + Tranexamic Acid contains mefenamic acid and tranexamic acid and is commonly prescribed for the management of heavy menstrual bleeding (menorrhagia) associated with menstrual pain. Heavy menstrual bleeding occurs when menstrual blood loss is excessive or prolonged, often affecting daily activities and quality of life. This combination works through two complementary mechanisms: mefenamic acid reduces pain and inflammation, while tranexamic acid reduces excessive bleeding by stabilising blood clots. Mefenamic Acid + Tranexamic Acid is commonly used during menstrual days when symptoms are most pronounced and should be taken under medical supervision.

Mefenamic Acid + Tranexamic Acid contains mefenamic acid, a non-steroidal anti-inflammatory drug (NSAID), and tranexamic acid, an antifibrinolytic medicine used together to manage heavy menstrual bleeding with associated dysmenorrhoea (period pain).

Mefenamic acid works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), which reduces the production of prostaglandins, chemical mediators responsible for uterine contractions, pain, and inflammation during menstruation. By lowering prostaglandin levels, it helps relieve abdominal cramps, pelvic pain, and discomfort associated with menstruation.

Tranexamic acid works differently by preventing the breakdown of fibrin clots through inhibition of plasminogen activation. This helps maintain clot stability within the uterine lining and significantly reduces menstrual blood loss.

This dual-action combination is particularly beneficial for women who experience both excessive bleeding and painful periods. It is often prescribed for short-term use during menstruation only, rather than continuous daily therapy.

The medicine usually begins to relieve pain within a few hours, while reduction in menstrual blood flow becomes noticeable during the same treatment cycle. Because tranexamic acid affects clotting pathways, patients with a history of thrombosis or clotting disorders require careful assessment before use.

When taken as prescribed, Mefenamic Acid + Tranexamic Acid provides effective symptom relief and helps improve comfort and daily functioning during menstruation.

Heavy Menstrual Bleeding (Menorrhagia)

Reduces excessive menstrual blood loss during periods.

Painful Menstruation (Dysmenorrhoea)

Relieves abdominal cramps and pelvic pain during menstruation.

Menstrual Discomfort

Helps manage associated symptoms such as lower back pain and pelvic heaviness.

Short-Term Menstrual Symptom Control

Used during active menstrual days for symptomatic relief.

• Dual Action Relief: Combines pain relief and bleeding control in one formulation.

• Reduces Menstrual Blood Loss: Tranexamic acid helps stabilise blood clots and reduce excessive bleeding.

• Relieves Menstrual Pain: Mefenamic acid reduces uterine cramps by lowering prostaglandin production.

• Improves Daily Comfort: Helps women maintain normal daily activities during menstruation.

• Short-Term Use Convenience: Usually required only during menstrual days.

• Supports Quality of Life: Particularly beneficial in women with heavy, painful periods affecting routine activities.

When taken as directed, Mefenamic Acid + Tranexamic Acid is generally well tolerated. Side effects are usually mild and temporary.

Common Side Effects

• Nausea or Vomiting: Mild stomach discomfort may occur after dosing.

• Diarrhoea or Indigestion: Gastrointestinal upset is relatively common with NSAIDs.

• Headache: Temporary headache may occur in some individuals.

• Abdominal Pain: Mild stomach discomfort may occur.

Uncommon Side Effects

• Dizziness: Occasional light-headedness may occur.

• Acidity or Gastric Irritation: More likely if taken on an empty stomach.

• Skin Rash: Mild allergic skin reactions may occur rarely.

Serious Side Effects (Require Immediate Medical Attention)

• Severe Allergic Reaction: Swelling of face, lips, or breathing difficulty.

• Blood Clot Symptoms: Sudden chest pain, leg swelling, or breathlessness.

• Severe Gastrointestinal Bleeding: Black stools, vomiting blood, or severe abdominal pain.

• Vision Changes: Rarely associated with tranexamic acid.

Mefenamic Acid + Tranexamic Acid should be taken exactly as prescribed by your physician. It is usually started at the onset of menstrual bleeding or pain and continued for the prescribed number of days during menstruation. Tablets should preferably be taken after food to reduce gastric irritation. Swallow the tablet whole with water. Do not exceed the recommended dose.

The mechanism of Mefenamic Acid + Tranexamic Acid is based on the complementary actions of mefenamic acid and tranexamic acid, which together help control menstrual pain and reduce excessive bleeding.

Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the cyclooxygenase enzymes COX-1 and COX-2, thereby reducing the synthesis of prostaglandins. Prostaglandins are chemical mediators responsible for uterine muscle contractions, inflammation, and pain during menstruation. By lowering prostaglandin levels, mefenamic acid helps reduce uterine cramps, pelvic discomfort, and menstrual pain.

Tranexamic acid is an antifibrinolytic agent that works by reversibly blocking the lysine-binding sites on plasminogen molecules. This prevents plasminogen from converting into plasmin, the enzyme responsible for breaking down fibrin clots. As a result, fibrin clot stability within the endometrium is maintained, which helps reduce excessive menstrual blood loss.

This dual mechanism allows Mefenamic Acid + Tranexamic Acid to provide effective relief from both heavy menstrual bleeding and period pain, making it particularly useful in women with menorrhagia associated with dysmenorrhoea.

• Take During Menstrual Days Only: Use only for the prescribed menstrual period.

• Take After Food: Helps reduce stomach irritation caused by mefenamic acid.

• Avoid Overuse: Do not exceed recommended duration.

• Monitor Bleeding Pattern: Consult your doctor if bleeding remains unusually heavy.

• Watch for Clotting Symptoms: Seek immediate medical advice if unusual swelling or chest pain develops.

• Inform About Medical History: Especially if you have clotting disorders or ulcers.

While Mefenamic Acid + Tranexamic Acid is best taken after food, certain dietary factors may influence tolerability.

• Alcohol (High): Increases gastric irritation and bleeding risk.

• Caffeine (Moderate): Excess caffeine may worsen abdominal discomfort.

• Spicy Foods (Moderate): May aggravate gastric irritation.

• Hydration (Recommended): Adequate fluid intake supports tolerability.

Mefenamic Acid + Tranexamic Acid can interact with several medicines.

• Anticoagulants (High): Increased risk of clotting imbalance or bleeding complications.

• Other NSAIDs (High): Increased gastric irritation and bleeding risk.

• Hormonal Medicines (Moderate): Some hormonal therapies may increase clot risk with tranexamic acid.

• Antiplatelet Medicines (Moderate): Increased bleeding or clotting considerations.

• Corticosteroids (Moderate): Higher gastric ulcer risk.

Mefenamic Acid + Tranexamic Acid should be used carefully in patients with certain medical conditions.

• Clotting Disorders (High): Tranexamic acid may increase clot risk.

• History of Thrombosis (High): Use only after medical evaluation.

• Peptic Ulcer Disease (High): NSAIDs may worsen gastric bleeding.

• Kidney Disease (Moderate): Reduced clearance may increase side effects.

• Asthma (Moderate): NSAIDs may trigger symptoms in susceptible individuals.

If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Skip the missed dose if your next dose is due soon. Do not take two doses together. Because treatment is short-term and symptom-based, follow your doctor’s advice carefully.