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Macitentan

Uses

Macitentan is used in the treatment of pulmonary arterial hypertension (PAH).

How it Works

How Macitentan works Macitentan is an endothelin receptor blocker. It inhibits the action of endothelin, a natural substance that causes blood vessels to constrict. This constriction increases the pressure in the blood vessels of the lungs. Macitentan helps relax these blood vessels and enhances the blood supply to the lungs.

Side Effects

Common side effects of Macitentan include headache, bronchitis (inflammation of the airways), nasopharyngitis (inflammation of the throat and nasal passages), anemia (low number of red blood cells), urinary tract infection, and influenza.

Expert Advice

  • Your doctor has prescribed Macitentan to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
  • It helps improve your quality of life, exercise ability, and delays disease progression.
  • Notify your doctor if you are pregnant, planning to conceive, or breastfeeding.
  • Your doctor may ask you to undergo routine blood tests to check for anemia and assess liver function.
  • Do not drive or engage in activities requiring concentration until you know how Macitentan affects you.
  • Inform your doctor if you notice:
    • Weight gain
    • Swelling of your arms and legs
    • Difficulty breathing
  • Additionally, inform your doctor if you experience:
    • Yellowing of the skin or eyes
    • Dark urine
    • Stomach pain

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Frequently asked questions

Macitentan should be taken once daily, with or without food. Swallow the tablet whole with water; do not crush or chew. For optimal results, take it at the same time each day.
There is evidence suggesting that Macitentan may reduce fertility in men and could lead to decreased sperm count. Discuss the potential risks with your doctor before starting treatment.
Symptoms of anemia include dizziness, pallor, weakness, rapid heart rate, and palpitations. Consult your doctor if you experience any of these symptoms.
Yes, Macitentan may lower blood pressure and can cause headaches. These side effects may impair your ability to drive or operate heavy machinery.
Your doctor will conduct blood tests before and during treatment to check for anemia and assess liver function.
Females capable of becoming pregnant should use two effective birth control methods during Macitentan treatment and for one month after discontinuation, as it takes time for the drug to clear from the body. Tubal sterilization, progesterone implants, or IUDs can be used alone. Consult your doctor if you have questions about birth control methods.
Macitentan can cause serious birth defects if taken during pregnancy. Pregnant women should not start treatment, and those on Macitentan should avoid becoming pregnant.
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