Levosulpiride is used in the treatment of gastroesophageal reflux disease (acid reflux), irritable bowel syndrome, heartburn, schizophrenia, and depression.
How Levosulpiride works Levosulpiride is an atypical antipsychotic. It functions by increasing the release of acetylcholine, a chemical messenger. This action enhances the movement of the stomach and intestines, and prevents reflux, which is the backward flow of acid into the esophagus.
Common side effects of Levosulpiride include increased prolactin levels in the blood, extrapyramidal symptoms, weight gain, akathisia (inability to stay still), increased liver enzymes, constipation, insomnia (difficulty sleeping), sedation, and maculopapular rash.