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Isosorbide Dinitrate

Uses

Isosorbide Dinitrate is used in the treatment of angina (heart-related chest pain), heart failure, coronary artery disease, hypertensive emergencies, and anal fissures.

How it Works

How Isosorbide Dinitrate Works Isosorbide Dinitrate is a nitrate that functions by relaxing blood vessels. This relaxation decreases the oxygen demand of the heart and reduces its workload, thereby preventing and treating attacks of angina (chest pain).

Side Effects

Common side effects of Isosorbide Dinitrate include headache.

Expert Advice

  • Eat a healthy diet (low-fat, high-fiber, low-sodium).
  • Quit smoking.
  • Increase your physical activity.
  • Monitor your weight.
  • Reduce stress.
  • Isosorbide Dinitrate may cause dizziness or sleepiness.
  • Do not drive or engage in activities requiring concentration until you know how it affects you.
  • Avoid alcohol consumption while taking Isosorbide Dinitrate, as it may increase dizziness.
  • Headaches may occur but usually resolve after a few days of continued treatment; inform your doctor if headaches persist.
  • You may develop tolerance to Isosorbide Dinitrate over time, meaning the same dose may become less effective.
  • Follow the prescribed dosing schedule to minimize tolerance.
  • Discontinue medications for erectile dysfunction (e.g., sildenafil or tadalafil) while on treatment with Isosorbide Dinitrate, as they may cause low blood pressure.
  • You have been prescribed Isosorbide Dinitrate for the prevention and treatment of heart-related chest pain (angina).

Other Combinations

Hydralazine + Isosorbide Dinitrate

Frequently asked questions

Isosorbide Dinitrate works by dilating blood vessels in the heart, increasing blood flow to areas that require it.
Isosorbide Dinitrate is an organic nitrate used to prevent and treat angina pectoris and as an adjunctive treatment for severe acute or chronic congestive heart failure.
Isosorbide Dinitrate does not lower heart rate; however, it may cause reflex tachycardia (increased heart rate) in some individuals.
Yes, Isosorbide Dinitrate lowers blood pressure by dilating blood vessels and reducing vascular resistance. Caution is advised for individuals with low blood pressure; consult your doctor if concerned.
No, combining sildenafil with Isosorbide Dinitrate is not recommended, as both lower blood pressure and may lead to significant hypotension, increasing the risk of fainting or heart attack. Avoid other similar medications like vardenafil and tadalafil.
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