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Isoniazid + Rifampicin

Uses

Rifampicin and Isoniazid are used in the treatment of tuberculosis.

How it Works

How Rifampicin and Isoniazid Work Rifampicin and Isoniazid are a combination of two antibiotics that treat tuberculosis (TB). Rifampicin inactivates a bacterial enzyme, RNA polymerase, which is essential for TB bacteria to produce vital proteins and reproduce. Isoniazid prevents these bacteria from forming their protective covering. Together, they kill the bacteria and eradicate the infection.

Side Effects

Common side effects of Rifampicin and Isoniazid include vomiting, nausea, peripheral neuropathy (tingling and numbness in the hands and feet), abdominal pain, skin rash, itching, hepatitis (viral infection of the liver), dizziness, lethargy, and low blood platelets.

Expert Advice

You have been prescribed Rifampicin + Isoniazid for the treatment of tuberculosis.
Complete the full course of the medication, even if you feel better. Stopping it early may cause the infection to return.
Take the medication on an empty stomach, preferably at the same time every day.
It may cause discolouration of your urine, sweat, saliva, and tears to a reddish-orange color. This is normal and not harmful.
Your doctor may check your liver function before starting treatment and regularly thereafter.
Inform your doctor if you notice any of the following symptoms:
- Yellowing of the eyes or skin
- Dark urine
- Stomach pain
Avoid drinking alcohol while taking Rifampicin + Isoniazid, as this may increase the risk of liver side effects.
Use an alternative or additional contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while taking Rifampicin + Isoniazid, as it may reduce the effectiveness of hormonal contraceptives like the pill.
Do not take indigestion remedies (antacids) within at least two hours of taking Rifampicin + Isoniazid.

Other Combinations

Ethambutol + Isoniazid + Piperine + Pyrazinamide + Rifampicin

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Ethambutol + Isoniazid + Rifampicin + Vitamin B6 (Pyridoxine)

Isoniazid + Piperine + Rifampicin

Isoniazid + Sodium aminosalicylate

Isoniazid + Vitamin B6 (Pyridoxine)

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin

Ethambutol + Isoniazid + Rifampicin

Isoniazid + Pyrazinamide + Rifampicin

Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Isoniazid + Rifampicin + Vitamin B6 (Pyridoxine)

Related Medications

Salt Composition

Isoniazid + Rifampicin 125mg

Lynacox Tablet DT

Lancer Healthcare Pvt. Ltd.

Strip of 10 tablets

MRP ₹11.2

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

R Cinex 450/300mg Tablet 10s

Strip of 10 tablets

MRP ₹128.7

Salt Composition

Isoniazid 100mg + Rifampicin 100mg

Recox 100mg/100mg Tablet

Jarson Pharmaceuticals

Strip of 10 tablets

MRP ₹14

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Rifazid A Forte Capsule 10s

Acichem Laboratories

Strip of 10 capsules

MRP ₹60

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Coxirid Plus Tablet

Apex Laboratories Pvt. Ltd.

Strip of 10 tablets

MRP ₹56

Salt Composition

Isoniazid 225mg + Rifampicin 400mg

Scc 2 400 mg/225 mg Tablet

Maneesh Pharmaceuticals Ltd.

Strip of 10 tablets

MRP ₹40.1

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Recox 450mg/300mg Tablet

Jarson Pharmaceuticals

Strip of 10 tablets

MRP ₹54.4

Salt Composition

Isoniazid 50mg + Rifampicin 100mg

Lynacox Kid 100 mg/50 mg Tablet

Lancer Healthcare Pvt. Ltd.

Strip of 10 tablets

MRP ₹12.1

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Secox 2 Capsule

Sierra Pharmaceuticals Ltd.

Strip of 10 capsules

MRP ₹63

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Mush 450/300mg Tablet 10s

Orison Pharma International

Strip of 10 tablets

MRP ₹52

Salt Composition

Isoniazid 300mg + Rifampicin 600mg

Bicox 600/300mg Tablet 10s

Overseas Healthcare Pvt. Ltd.

Strip of 10 tablets

MRP ₹64.1

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Nkt Plus 450mg/300mg Tablet

Asian Pharmaceuticals Pvt. Ltd.

Strip of 10 tablets

MRP ₹65

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

N Cox Plus 450mg/300mg Capsule

Unicure India Pvt. Ltd.

Strip of 10 capsules

MRP ₹67.5

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Mexcox Plus 450mg/300mg Tablet

Mexon Healthcare Ltd.

Strip of 10 tablets

MRP ₹68.7

Salt Composition

Isoniazid 300mg + Rifampicin 100mg

Coxwin ZH Kid 100 mg/300 mg Tablet

Marc Laboratories Pvt. Ltd.

Strip of 10 tablets

MRP ₹20.2

Salt Composition

Isoniazid 150mg + Rifampicin 300mg

Scc 2 LW 300 mg/150 mg Tablet

Maneesh Pharmaceuticals Ltd.

Strip of 10 tablets

MRP ₹38.5

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Tubachem 450mg/300mg Tablet

Chemo Biological

Strip of 10 tablets

MRP ₹48

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Antex 450mg/300mg Tablet

Gujarat Terce Laboratories Ltd.

Strip of 10 tablets

MRP ₹72.2

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

COXINEX 450MG/300MG CAPSULE

Aristo Pharmaceuticals Pvt. Ltd.

Strip of 10 capsules

MRP ₹65.1

Salt Composition

Isoniazid 225mg + Rifampicin 450mg

Scc 2 450 mg/225 mg Powder

Maneesh Pharmaceuticals Ltd.

Box of 1 powders

MRP ₹16.5

Salt Composition

Isoniazid 75mg + Rifampicin 150mg

Ticinex 150mg/75mg Tablet

Themis Medicare Ltd.

Strip of 6 tablets

MRP ₹11.7

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Akt 2 300/450mg Tablet 10s

Strip of 10 tablets

MRP ₹129.1

Salt Composition

Isoniazid NA + Rifampicin NA

Akurit LD Tablet 6s

Strip of 6 tablets

MRP ₹13

Salt Composition

Isoniazid 50mg + Rifampicin 100mg

R-Cinex 100mg/50mg Tablet

Strip of 10 tablets

MRP ₹46.3

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Rinex 450mg/300mg Tablet

Hamax Pharmaceuticals

Strip of 10 tablets

MRP ₹49.6

Frequently asked questions

What is Rifampicin+Isoniazid?

Rifampicin+Isoniazid is a combination medication used to treat tuberculosis. Rifampicin inhibits bacterial RNA-polymerase, essential for bacterial protein synthesis and reproduction, while Isoniazid prevents the bacteria from forming a protective covering. Together, they effectively kill the bacteria and eliminate the infection.

Does Rifampicin+Isoniazid change urine color?

Yes, Rifampicin+Isoniazid can cause urine, skin, sweat, saliva, tears, and feces to turn brownish-red or orange. This change is harmless.

What is the best time to take Rifampicin+Isoniazid?

Take Rifampicin+Isoniazid as directed by your doctor, preferably on an empty stomach—one hour before or two hours after meals.

What are the storage and disposal instructions for Rifampicin+Isoniazid?

Store the medication in its original container, tightly closed, following the storage instructions on the label. Dispose of any unused medicine properly to prevent accidental ingestion by pets, children, or others.

Does Rifampicin+Isoniazid affect the effectiveness of birth control pills?

Yes, Rifampicin+Isoniazid can reduce the effectiveness of birth control pills. Consult your doctor about alternative contraceptive methods that do not affect hormone levels, such as condoms or diaphragms.

What is the most important information to know about Rifampicin+Isoniazid?

Complete the full course of the prescribed medication, even if you feel better. Avoid alcohol during treatment to reduce the risk of liver damage. Contact your doctor immediately if you experience vision changes, loss of appetite, fatigue, stomach pain, nausea, vomiting, yellowing of the skin or eyes, or dark urine.

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