Isoniazid + Rifampicin

Uses

Rifampicin and Isoniazid are used in the treatment of tuberculosis.

How it Works

How Rifampicin and Isoniazid Work Rifampicin and Isoniazid are a combination of two antibiotics that treat tuberculosis (TB). Rifampicin inactivates a bacterial enzyme, RNA polymerase, which is essential for TB bacteria to produce vital proteins and reproduce. Isoniazid prevents these bacteria from forming their protective covering. Together, they kill the bacteria and eradicate the infection.

Side Effects

Common side effects of Rifampicin and Isoniazid include vomiting, nausea, peripheral neuropathy (tingling and numbness in the hands and feet), abdominal pain, skin rash, itching, hepatitis (viral infection of the liver), dizziness, lethargy, and low blood platelets.

Expert Advice

You have been prescribed Rifampicin + Isoniazid for the treatment of tuberculosis.
Complete the full course of the medication, even if you feel better. Stopping it early may cause the infection to return.
Take the medication on an empty stomach, preferably at the same time every day.
It may cause discolouration of your urine, sweat, saliva, and tears to a reddish-orange color. This is normal and not harmful.
Your doctor may check your liver function before starting treatment and regularly thereafter.
Inform your doctor if you notice any of the following symptoms:
- Yellowing of the eyes or skin
- Dark urine
- Stomach pain
Avoid drinking alcohol while taking Rifampicin + Isoniazid, as this may increase the risk of liver side effects.
Use an alternative or additional contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while taking Rifampicin + Isoniazid, as it may reduce the effectiveness of hormonal contraceptives like the pill.
Do not take indigestion remedies (antacids) within at least two hours of taking Rifampicin + Isoniazid.

Other Combinations

Ethambutol + Isoniazid + Piperine + Pyrazinamide + Rifampicin

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Ethambutol + Isoniazid + Rifampicin + Vitamin B6 (Pyridoxine)

Isoniazid + Piperine + Rifampicin

Isoniazid + Sodium aminosalicylate

Isoniazid + Vitamin B6 (Pyridoxine)

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin

Ethambutol + Isoniazid + Rifampicin

Isoniazid + Pyrazinamide + Rifampicin

Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Isoniazid + Rifampicin + Vitamin B6 (Pyridoxine)

Related Medications

Salt Composition

Isoniazid + Rifampicin 125mg

Lynacox Tablet DT

Lancer Healthcare Pvt. Ltd.

Strip of 10 tablets

MRP ₹11.2

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

MRP ₹137.3

Isoniazid 300mg + Rifampicin 450mg

CADIRIFA 450MG/300MG TABLET

Cadila Healthcare Ltd.

Strip of 10 tablets

MRP ₹39.3

Salt Composition

Isoniazid 30mg + Rifampicin 60mg

Ticinex Kid 60mg/30mg Tablet

Themis Medicare Ltd.

Strip of 6 tablets

MRP ₹5.8

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Twinculor 450mg/300mg Tablet

TOSC International Pvt. Ltd.

Strip of 10 tablets

MRP ₹67.6

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Coxbact 2 450mg/300mg Tablet

Alpic Remedies Ltd.

Strip of 10 tablets

MRP ₹69

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Parkox 450/300mg Tablet 10s

Park Pharmaceuticals

Strip of 10 tablets

MRP ₹69.5

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Eurorif 450mg/300mg Tablet

Euro Biogenics

Strip of 10 tablets

MRP ₹52

Salt Composition

Isoniazid 50mg + Rifampicin 100mg

Vicox 2 Kid Tablet

Shrinivas Gujarat Laboratories Pvt. Ltd.

Strip of 10 tablets

MRP ₹25

Salt Composition

Isoniazid 75mg + Rifampicin 150mg

Vicox 4 150 mg/75 mg Tablet

Shrinivas Gujarat Laboratories Pvt. Ltd.

Bottle of 100 tablets

MRP ₹354.5

Salt Composition

Isoniazid 50mg + Rifampicin 100mg

Rifaden Kid 100mg/50mg Tablet

Eden Healthcare Pvt. Ltd.

Strip of 10 tablets

MRP ₹13

Salt Composition

Isoniazid 100mg + Rifampicin 100mg

Nkt Kid 100mg/100mg Tablet

Asian Pharmaceuticals Pvt. Ltd.

Strip of 10 tablets

MRP ₹14

Salt Composition

Isoniazid 100mg + Rifampicin 100mg

Osorifa Plus KID 100/100mg Tablet 10s

Osho Pharma Pvt. Ltd.

Strip of 10 tablets

MRP ₹12.3

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Isorif 450mg/300mg Tablet

Dyochem Laboratories

Strip of 10 tablets

MRP ₹53

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Coxibin Plus 450mg/300mg Capsule

Bindlysh Biotec Ltd.

Strip of 10 capsules

MRP ₹54

Salt Composition

Isoniazid 50mg + Rifampicin 100mg

Bicox Kid 100/50mg Tablet 10s

Overseas Healthcare Pvt. Ltd.

Strip of 10 tablets

MRP ₹12.6

Salt Composition

Isoniazid 75mg + Rifampicin 150mg

Scc JR 150 mg/75 mg Tablet

Maneesh Pharmaceuticals Ltd.

Strip of 10 tablets

MRP ₹19.2

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Rifarcin Plus 450/300mg Tablet 10s

Reliance Formulation Pvt. Ltd.

Strip of 10 tablets

MRP ₹56.2

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Remcox 450mg/300mg Tablet

Remed Healthcare Pvt. Ltd.

Strip of 10 tablets

MRP ₹68

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

RIMPAZID 450MG/300MG TABLET

Cadila Healthcare Ltd.

Strip of 10 tablets

MRP ₹63.6

Salt Composition

Isoniazid 150mg + Rifampicin 300mg

Scc 2 LW 300mg/150mg Pouch

Maneesh Pharmaceuticals Ltd.

Packet of 1 tablets

MRP ₹13

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Optimat 450mg/300mg Tablet

Terrace Pharmaceuticals

Strip of 10 tablets

MRP ₹70

Salt Composition

Isoniazid 75mg + Rifampicin 150mg

Exact 2 Tablet

Marc Laboratories Pvt. Ltd.

Strip of 10 tablets

MRP ₹147.3

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Anacox Plus 450/300mg Tablet 4s

Ajanta Pharma Ltd.

Strip of 4 tablets

MRP ₹26

Salt Composition

Isoniazid 300mg + Rifampicin 450mg

Coxwin 2 Tablet

Marc Laboratories Pvt. Ltd.

Strip of 10 tablets

MRP ₹43.8

Frequently asked questions

What is Rifampicin+Isoniazid?

Rifampicin+Isoniazid is a combination medication used to treat tuberculosis. Rifampicin inhibits bacterial RNA-polymerase, essential for bacterial protein synthesis and reproduction, while Isoniazid prevents the bacteria from forming a protective covering. Together, they effectively kill the bacteria and eliminate the infection.

Does Rifampicin+Isoniazid change urine color?

Yes, Rifampicin+Isoniazid can cause urine, skin, sweat, saliva, tears, and feces to turn brownish-red or orange. This change is harmless.

What is the best time to take Rifampicin+Isoniazid?

Take Rifampicin+Isoniazid as directed by your doctor, preferably on an empty stomach—one hour before or two hours after meals.

What are the storage and disposal instructions for Rifampicin+Isoniazid?

Store the medication in its original container, tightly closed, following the storage instructions on the label. Dispose of any unused medicine properly to prevent accidental ingestion by pets, children, or others.

Does Rifampicin+Isoniazid affect the effectiveness of birth control pills?

Yes, Rifampicin+Isoniazid can reduce the effectiveness of birth control pills. Consult your doctor about alternative contraceptive methods that do not affect hormone levels, such as condoms or diaphragms.

What is the most important information to know about Rifampicin+Isoniazid?

Complete the full course of the prescribed medication, even if you feel better. Avoid alcohol during treatment to reduce the risk of liver damage. Contact your doctor immediately if you experience vision changes, loss of appetite, fatigue, stomach pain, nausea, vomiting, yellowing of the skin or eyes, or dark urine.

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