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Human adenovirus vector vaccine

Uses

Human adenovirus vector vaccine is used to prevent coronavirus disease (COVID-19).

How it Works

How the human adenovirus vector vaccine works: The SARS-CoV-2 virus, which causes COVID-19, uses proteins known as spike proteins to enter the cells in our body. The human adenovirus vector vaccine contains two different adenovirus vectors (rAd26 and rAd5), which are administered separately in the first and second doses, respectively. These vectors carry the gene for producing the SARS-CoV-2 spike protein but have been modified so that they cannot cause the disease. Once vaccinated, the body generates antibodies against the coronavirus, helping to fight the virus if exposed. This results in a reduced risk of developing the illness and its associated complications. Using different vectors enhances the immune response even more than using the same vector twice and may provide longer-lasting protection against the virus upon exposure.

Side Effects

Common side effects of the human adenovirus vector vaccine include injection site pain, tiredness, and fever.

Expert Advice

  • Human adenovirus vector vaccine is a 2-dose vaccination regimen.
  • The second dose is administered 21 days after the first dose.
  • The vaccine is given intramuscularly into the upper arm.
  • In addition to vaccination, observe other control measures such as:
    • Social distancing
    • Mask-wearing
    • Hand-washing
  • The human adenovirus vector vaccine is currently not intended for administration in children, as safety and efficacy have not yet been established.

Other Combinations

Related Medications

Frequently asked questions

COVID-19, or Coronavirus disease 2019, is a highly contagious respiratory illness caused by the SARS-CoV-2 virus. It is characterized by symptoms such as breathing difficulties, fever, and cough.
Emergency Use Authorization (EUA) is a regulatory declaration allowing specific vaccines, medicines, or devices to be used during public health emergencies, such as the COVID-19 outbreak. While these measures may not have full approval, they can be authorized based on a risk-benefit analysis, with ongoing assessments of safety and effectiveness.
In addition to the Human adenovirus vector vaccine, 14 vaccines have been approved globally, including Pfizer-BioNTech, Oxford/AstraZeneca, Moderna, Janssen (Johnson & Johnson), Covaxin, and Covishield. These vaccines utilize various technologies, including viral vector, RNA-based, and inactivated protein subunit approaches, all aimed at preventing COVID-19.
The Human adenovirus vector vaccine has reported an efficacy of over 90%, with clinical trial data published in The Lancet indicating no serious adverse events. Most side effects are mild, including flu-like symptoms, injection site reactions, headache, and fatigue.
The Human adenovirus vector vaccine has an efficacy rate exceeding 90%, specifically 91.6%, based on data from over 19,800 volunteers who received both doses.
The safety and effectiveness of the Human adenovirus vector vaccine have not been studied in children. Current guidelines recommend it only for individuals aged 18 and older, so it is advised not to vaccinate children until more data is available.
Common side effects include pain at the injection site, fatigue, and fever. These are typically mild and resolve over time. If they persist or cause concern, consult your doctor for advice.
According to Russian guidelines, the Human adenovirus vector vaccine can be stored at temperatures between +2 to +8 degrees Celsius, facilitating global distribution.
Yes, it is crucial to receive both doses of the Human adenovirus vector vaccine, as each dose contains a different weakened adenovirus vector. Trials have shown that receiving both doses, spaced 21 days apart, leads to better and longer-lasting immunity.
Yes, the Human adenovirus vector vaccine is expected to provide protection against newer strains of the COVID-19 virus. The vaccine prompts the body to produce multiple types of antibodies that can effectively combat the virus, and current data suggests that mutations are unlikely to render the vaccine ineffective.
Yes, individuals who have had a prior COVID-19 infection should still get vaccinated, as the vaccine serves as a booster to enhance the immune response. There have been cases of reinfection, highlighting the importance of vaccination.
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