Gliclazide + Metformin

Gliclazide+Metformin is a combination medication used to treat type 2 diabetes mellitus. It helps improve blood glucose levels in adults when combined with a proper diet and regular exercise. Gliclazide increases insulin release from the pancreas, while Metformin reduces glucose production in the liver and enhances insulin sensitivity. This combination is not suitable for treating Type 1 diabetes.

Yes, Gliclazide+Metformin can cause hypoglycemia, characterized by symptoms such as nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate, and anxiety. The risk increases if meals are missed, alcohol is consumed, excessive exercise occurs, or other antidiabetic medications are taken. Regular blood sugar monitoring is essential, and it's advisable to carry glucose tablets, honey, or fruit juice.

Yes, Gliclazide+Metformin can lead to lactic acidosis, a rare but serious condition resulting from elevated lactic acid levels in the blood. It is particularly risky for patients with kidney disease, older adults, or those who consume excessive alcohol. Symptoms include muscle pain, dizziness, fatigue, cold extremities, difficulty breathing, nausea, vomiting, stomach pain, and slow heart rate. If these symptoms occur, discontinue use and consult a doctor immediately.

Yes, long-term use of Gliclazide+Metformin can result in vitamin B12 deficiency due to impaired absorption. Untreated deficiency may lead to anemia and nerve issues, causing symptoms like tingling, numbness, weakness, urinary problems, altered mental status, and balance difficulties. To prevent these issues, some experts recommend annual vitamin B12 supplementation.

Common side effects of Gliclazide+Metformin include hypoglycemia, altered taste, nausea, stomach pain, diarrhea, headache, and upper respiratory infections. Serious but rare side effects include lactic acidosis, and long-term use may lead to vitamin B12 deficiency.

No, it is not safe to consume alcohol while taking Gliclazide+Metformin, as it may lower blood sugar levels and increase the risk of lactic acidosis.

Gliclazide+Metformin should be avoided in individuals with known allergies to its components, moderate to severe kidney disease, or underlying metabolic acidosis, including diabetic ketoacidosis.