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Glibenclamide + Metformin

Uses

Glibenclamide and Metformin are used in the treatment of type 2 diabetes mellitus.

How it Works

How Glibenclamide and Metformin Work Glibenclamide is a sulfonylurea that increases the amount of insulin released by the pancreas to lower blood glucose levels. Metformin is a biguanide that reduces glucose production in the liver, delays glucose absorption from the intestines, and enhances the body's sensitivity to insulin.

Side Effects

Common side effects of Glibenclamide and Metformin include diarrhea, nausea, flatulence, dizziness, headache, and upper respiratory tract infection.

Expert Advice

  • Take it with food to reduce the risk of an upset stomach.
  • Continue to exercise regularly, maintain a healthy diet, and take your other diabetes medications alongside Glibenclamide + Metformin.
  • Be aware that it can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medications, alcohol, or if you delay or miss a meal.
  • Inform your doctor about your diabetes treatment if you are scheduled for surgery under general anesthesia.
  • Notify your doctor immediately if you experience any of the following:
    • Deep or rapid breathing
    • Persistent nausea
    • Vomiting
    • Stomach pain
  • Glibenclamide + Metformin may lead to a rare but serious condition called lactic acidosis, characterized by an excess of lactic acid in the blood.
  • Your doctor may monitor your liver function regularly.
  • Inform your doctor if you develop any of the following symptoms:
    • Abdominal pain
    • Loss of appetite
    • Yellowing of the eyes or skin (jaundice)

Other Combinations

Glibenclamide + Metformin + Pioglitazone

Glibenclamide + Metformin + Rosiglitazone

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Frequently asked questions

What is type 2 diabetes?
Type 2 diabetes is the most prevalent form of diabetes, characterized by the body's inability to produce sufficient insulin or ineffective use of the insulin produced. This leads to elevated blood glucose levels, resulting in serious health complications. Symptoms include frequent urination, increased thirst, and heightened hunger. If untreated, it can cause long-term issues such as neuropathy, nephropathy, retinopathy, foot problems, and an increased risk of heart disease.
What is Glibenclamide and Metformin?
Glibenclamide and Metformin is a combination medication used to treat type 2 diabetes mellitus (DM). It helps improve blood glucose levels in adults when combined with a proper diet and regular exercise. Glibenclamide increases insulin release from the pancreas, while Metformin reduces glucose production in the liver and enhances insulin sensitivity. This combination is not suitable for treating Type 1 DM.
Can Glibenclamide and Metformin cause hypoglycemia?
Yes, Glibenclamide and Metformin can cause hypoglycemia. Symptoms include nausea, headache, irritability, hunger, sweating, dizziness, rapid heartbeat, and anxiety. The risk increases if meals are missed, alcohol is consumed, excessive exercise occurs, or other antidiabetic medications are taken concurrently. Regular blood sugar monitoring is essential, and it is advisable to keep a quick source of sugar, such as glucose tablets or fruit juice, on hand.
Can Glibenclamide and Metformin lead to vitamin B12 deficiency?
Yes, long-term use of Glibenclamide and Metformin can lead to vitamin B12 deficiency due to impaired absorption in the stomach. Untreated deficiency may result in anemia and nerve issues, including tingling, numbness, weakness, urinary problems, altered mental status, and balance difficulties. Some researchers recommend annual vitamin B12 supplementation.
What are the possible side effects of Glibenclamide and Metformin?
Common side effects of Glibenclamide and Metformin include hypoglycemia, altered taste, nausea, stomach pain, diarrhea, headache, and upper respiratory infections. Rare but serious side effects may include lactic acidosis, and long-term use can lead to vitamin B12 deficiency.
Is it safe to consume alcohol while taking Glibenclamide and Metformin?
No, it is unsafe to consume alcohol while taking Glibenclamide and Metformin, as it may exacerbate hypoglycemia and increase the risk of lactic acidosis.
What are the storage and disposal instructions for Glibenclamide and Metformin?
Store Glibenclamide and Metformin in its original container, tightly closed, according to the label instructions. Dispose of any unused medication properly to prevent accidental ingestion by pets, children, or others.
Are there specific conditions where Glibenclamide and Metformin should not be taken?
Glibenclamide and Metformin should be avoided in individuals with known allergies to its components, moderate to severe kidney disease, or underlying metabolic acidosis, including diabetic ketoacidosis.
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