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Finerenone

Uses

Finerenone is used to prevent chronic kidney disease.

How it Works

How Finerenone works Finerenone is a nonsteroidal, selective antagonist of the mineralocorticoid receptor (MR). This receptor, typically activated by hormones such as aldosterone and cortisol, plays a crucial role in regulating sodium levels in the body. Finerenone blocks and prevents overactivation of this receptor, which can lead to damage in various parts of the body, including the kidneys, heart, and blood vessels.

Side Effects

Common side effects of Finerenone include increased potassium levels in the blood, hypotension (low blood pressure), and decreased sodium levels in the blood.

Expert Advice

  • Avoid breastfeeding during treatment with Finerenone and for one day after treatment.
  • For patients who cannot swallow whole tablets, Finerenone may be crushed and mixed with water or soft foods before administration.
  • Inform your doctor if you are taking potassium supplements or any other medications for high blood pressure or heart disease.
  • Women of childbearing potential should use effective contraception during treatment to prevent pregnancy.
  • Finerenone contains lactose; inform your doctor if you have lactose intolerance.

Other Combinations

Related Medications

Frequently asked questions

Breastfeeding is not advised during Finerenone treatment and for one day following the treatment.
Finerenone dosing is determined by estimated glomerular filtration rate (eGFR). The initial dose is 20 mg daily for eGFR ≥ 60 mL/min and 10 mg daily for eGFR between 25 and < 60 mL/min. It is not recommended for patients with eGFR < 25 mL/min. Dosage adjustments may be made for high potassium levels.
Yes, Finerenone may cause a reduction in blood pressure, potentially leading to hypotension.
Yes, Finerenone can lead to hyperkalemia (elevated potassium levels), particularly in patients with impaired kidney function or pre-existing high potassium levels. Your doctor will likely monitor your potassium levels before and during treatment and may adjust the dosage as needed.
Yes, studies indicate that Finerenone lowers the risk of new-onset heart failure and enhances heart failure outcomes in patients with chronic kidney disease and type 2 diabetes, regardless of prior heart failure or heart disease history.
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