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Evolocumab

Uses

Evolocumab is used in the treatment of high cholesterol and atherosclerosis, which involves plaque deposition inside the arteries.

How it Works

Evolocumab works by inhibiting the production of LDL cholesterol, thereby reducing the cholesterol that may accumulate on the walls of the arteries and obstruct blood flow to the heart, brain, and other parts of the body.

Side Effects

Common side effects of Evolocumab include nasopharyngitis (inflammation of the throat and nasal passages), upper respiratory tract infection, infection, influenza, back pain, and injection site reactions (pain, swelling, redness).

Expert Advice

  • Before taking Evolocumab, inform your doctor if you are allergic to rubber or latex, as the needle covers on the syringe contain dry natural rubber.
  • Inform your doctor immediately if you experience any of the following symptoms:
    • Swelling
    • Fatigue
    • Muscle weakness
    • Muscle pain
  • Your doctor may check your liver function before starting treatment and regularly thereafter.
  • If you are diabetic, monitor your blood sugar levels regularly, as Evolocumab may increase them.
  • Lifestyle changes that may enhance the effectiveness of Evolocumab include:
    • Adopting a low-fat and low-salt diet
    • Engaging in regular exercise
    • Avoiding smoking
    • Reducing alcohol consumption

Related Medications

Frequently asked questions

Evolocumab is injected subcutaneously in the abdomen, thigh, or upper arm every two weeks or once a month.
HDL, or high-density lipoprotein, is referred to as good cholesterol because it transports cholesterol from the blood to the liver for removal, thereby reducing heart disease risk.
You can schedule a lipid profile test at an accredited laboratory to monitor total cholesterol, LDL, HDL, triglycerides, and cholesterol-to-HDL ratio. Fasting for 10-12 hours prior to the test may be required. Consult your doctor to evaluate the results.
LDL, or low-density lipoprotein, is known as bad cholesterol because it contributes to cholesterol buildup in the blood, leading to blockages that can cause heart attacks, strokes, and peripheral artery disease.
Evolocumab is an injectable medication prescribed to lower cholesterol levels and reduce the risk of heart attacks in adults.
Statins inhibit cholesterol production in the liver, while Evolocumab enhances the liver's ability to remove LDL cholesterol by blocking the PCSK9 protein, resulting in lower blood cholesterol levels.
High cholesterol can accumulate in artery walls, narrowing blood vessels and reducing blood flow to the heart, potentially leading to heart attacks or strokes.
Evolocumab can reduce LDL cholesterol levels in one month, achieving up to a 63% reduction in three months, though individual results may vary. Consult your doctor if you do not see improvement.
Normal total cholesterol levels should be between 125 to 200 mg/dL, LDL should be less than 100 mg/dL, and HDL should be 40 mg/dL or higher.
Evolocumab should be taken as long as prescribed; discontinuing it abruptly can lead to increased cholesterol levels.
To improve the effectiveness of Evolocumab, adopt a low-fat diet, exercise regularly, maintain a healthy weight, and limit alcohol consumption.
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