How Evogliptin and Metformin Work Evogliptin and Metformin are antidiabetic medications. Evogliptin functions by increasing insulin release from the pancreas and decreasing the hormones that elevate blood sugar levels, thereby reducing fasting and post-meal sugar levels. Metformin works by lowering glucose production in the liver, delaying the absorption of glucose from the intestines, and enhancing the body's sensitivity to insulin.