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Ethambutol + Isoniazid + Pyrazinamide + Rifampicin

Uses

Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide are used in the treatment of tuberculosis.

How it Works

How Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide work: Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide is a combination of four medications.

Side Effects

Common side effects of Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide include nausea, vomiting, peripheral neuropathy (tingling and numbness in the feet and hands), abdominal pain, skin rash, hepatitis (viral infection of the liver), lethargy, low blood platelets, joint pain, thrombocytopenic purpura, cutaneous reactions, and retrobulbar optic neuritis.

Expert Advice

You have been prescribed Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide for the treatment of tuberculosis.
Take the medication on an empty stomach and preferably at the same time every day.
Avoid missing a dose, as this increases the risk of the bacteria becoming resistant to the medication and may also heighten the risk of side effects.
The medication may cause discoloration of your urine, sweat, saliva, and tears, resulting in a reddish/orange color. This is normal and not harmful.
Your doctor may check your liver function before starting treatment and regularly thereafter.
Inform your doctor if you notice any of the following symptoms:
- Yellowing of eyes or skin
- Dark urine
- Stomach pain
Avoid consuming alcohol while taking Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide, as this may increase the risk of liver side effects.
The medication may cause vitamin B6 deficiency. Your doctor may prescribe vitamin B6 supplements to help prevent potential issues related to its deficiency, such as inflammation of the nerves (neuritis).
Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while taking Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide, as it may reduce the effectiveness of hormonal contraceptives like the pill.
Do not take indigestion remedies (antacids) within at least two hours of taking the medication.
Complete the full course of the medication, even if you feel better. Stopping treatment early increases the risk of the infection returning.

Other Combinations

Ethambutol + Isoniazid + Piperine + Pyrazinamide + Rifampicin

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Ethambutol + Isoniazid + Rifampicin + Vitamin B6 (Pyridoxine)

Ethambutol + Isoniazid

Ethambutol + Isoniazid + Rifampicin

Related Medications

Salt Composition

Ethambutol + Isoniazid 300mg + Pyrazinamide + Rifampicin 800mg

AC 4 Kit 5s

Alembic Pharmaceuticals Ltd.

Strip of 5 kit

MRP ₹15.1

Salt Composition

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

MRP ₹15.8

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

MRP ₹19.7

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

Scc 4 Plus Pouch

Maneesh Pharmaceuticals Ltd.

Packet of 1 unit

MRP ₹28.6

Salt Composition

Ethambutol + Isoniazid + Pyrazinamide + Rifampicin + Vitamin B6 (Pyridoxine)

MRP ₹25

Ethambutol 120mg + Isoniazid 250mg + Pyrazinamide + Rifampicin 80mg

MRP ₹68.3

Ethambutol 550mg + Isoniazid 150mg + Pyrazinamide 750mg + Rifampicin 450mg

Coxina 4 Tablet

Aristo Pharmaceuticals Pvt. Ltd.

Strip of 3 tablets

MRP ₹11.6

Salt Composition

Ethambutol 800mg + Isoniazid 300mg + Pyrazinamide 750mg + Rifampicin 450mg

MRP ₹12.3

Ethambutol NA + Isoniazid NA + Pyrazinamide NA + Rifampicin NA

Scc Kit

Maneesh Pharmaceuticals Ltd.

Packet of 3 kit

MRP ₹10.3

Salt Composition

Ethambutol 275mg + Isoniazid 75mg + Pyrazinamide 400mg + Rifampicin 150mg

Trac 4 Tablet

Macleods Pharmaceuticals Pvt. Ltd.

Strip of 6 tablets

MRP ₹34

Salt Composition

Ethambutol NA + Isoniazid NA + Pyrazinamide NA + Rifampicin NA

Scc 4 Pouch

Maneesh Pharmaceuticals Ltd.

Packet of 1 gm

MRP ₹11.9

Salt Composition

Ethambutol 275mg + Isoniazid 75mg + Pyrazinamide 400mg + Rifampicin 150mg

MRP ₹60.1

Ethambutol 400mg + Isoniazid 150mg + Pyrazinamide 750mg + Rifampicin 225mg

MRP ₹54.6

Ethambutol 400mg + Isoniazid 150mg + Pyrazinamide 750mg + Rifampicin 225mg

Mycotube Plus Tablet

Indillina Pharmaceuticals Ltd.

Strip of 6 tablets

MRP ₹53.6

Salt Composition

Ethambutol 275mg + Isoniazid 75mg + Pyrazinamide 400mg + Rifampicin 150mg

MRP ₹58

Ethambutol NA + Isoniazid NA + Pyrazinamide NA + Rifampicin NA

Exact 4 Tablet

Marc Laboratories Pvt. Ltd.

Strip of 10 tablets

MRP ₹35.6

Salt Composition

Ethambutol 800mg + Isoniazid 300mg + Pyrazinamide 1500mg + Rifampicin 450mg

Monto 4 Combipack

Shreya Life Sciences Pvt. Ltd.

Packet of 1 tablets

MRP ₹16.7

Salt Composition

Ethambutol 1100mg + Isoniazid 300mg + Pyrazinamide 800mg + Rifampicin 600mg

MRP ₹14.5

Ethambutol 550mg + Isoniazid 150mg + Pyrazinamide 750mg + Rifampicin 450mg

INFEZ 4 TABLET

Shreya Life Sciences Pvt. Ltd.

Strip of 3 tablets

MRP ₹13.8

Salt Composition

Ethambutol 800mg + Isoniazid 150mg + Pyrazinamide 225mg + Rifampicin 225mg

Infez 3 Kit

Shreya Life Sciences Pvt. Ltd.

Packet of 1 Kit

MRP ₹14.7

Salt Composition

Ethambutol NA + Isoniazid NA + Pyrazinamide NA + Rifampicin NA

Coxter Kit 4 Tablet

Alkem Laboratories Ltd.

Strip of 4 tablets

MRP ₹11.9

Salt Composition

Ethambutol 800mg + Isoniazid 300mg + Pyrazinamide 750mg + Rifampicin 450mg

MYCOCOX-4 KIT

Cadila Healthcare Ltd.

Strip of 4 tablets

MRP ₹11.2

Salt Composition

Ethambutol NA + Isoniazid NA + Pyrazinamide NA + Rifampicin NA

MRP ₹11.9

Ethambutol 400mg + Isoniazid 150mg + Pyrazinamide 750mg + Rifampicin 225mg

Forecox Tablet 6s

Macleods Pharmaceuticals Pvt. Ltd.

Strip of 6 tablets

MRP ₹90.9

Salt Composition

Ethambutol 400mg + Isoniazid 150mg + Pyrazinamide 750mg + Rifampicin 225mg

R-Cinex EZ Tablet

Lupin Ltd.

Strip of 6 tablets

MRP ₹93

Frequently asked questions

How should I take Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide?

Take Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide on an empty stomach, at least one hour before or two hours after a meal, with a full glass of water.

Can Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide affect my vision?

Yes, Ethambutol may cause visual impairment. Inform your doctor immediately if you notice any changes in your eyesight.

Does Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide cause urine discoloration?

Yes, Rifampicin can cause temporary discoloration of urine, sweat, saliva, and tears (red, orange, or brown). However, if urine discoloration is accompanied by stomach pain, loss of appetite, or jaundice, contact your doctor as it may indicate liver damage.

Is it safe to drink alcohol while taking Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide?

No, avoid alcohol while taking these medications as it increases the risk of hepatitis associated with Isoniazid.

Can I use oral contraceptives while taking Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide?

No, these medications may reduce the effectiveness of birth control pills. Consult your doctor for alternative contraceptive methods that do not affect hormone levels.

Is it safe to stop taking Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide if I feel better?

No, do not discontinue these medications without consulting your doctor, as stopping early can worsen your infection and lead to drug-resistant tuberculosis.

What are the storage and disposal instructions for Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide?

Store the medicine in its original container, tightly closed, and follow the storage instructions on the label. Dispose of any unused medicine safely to prevent accidental ingestion by pets, children, or others.

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