Ethambutol + Isoniazid + Piperine + Pyrazinamide + Rifampicin

Uses

Rifampicin, Isoniazid, Piperine, Ethambutol, and Pyrazinamide are used in the treatment of tuberculosis.

How it Works

How Rifampicin, Isoniazid, Piperine, Ethambutol, and Pyrazinamide Work Rifampicin, Isoniazid, Piperine, Ethambutol, and Pyrazinamide is a combination of five medicines used to treat tuberculosis (TB). Rifampicin works by inactivating a bacterial enzyme (RNA polymerase) that TB bacteria require to produce essential proteins and reproduce, while Isoniazid prevents these bacteria from forming their protective covering. Together, they kill the bacteria and eradicate the infection. Ethambutol and Pyrazinamide, on the other hand, work by slowing the growth of these bacteria. Vitamin B6 (pyridoxine) is added to prevent nerve damage, which may be a side effect of Isoniazid.

Side Effects

Common side effects of Rifampicin, Isoniazid, Piperine, Ethambutol, and Pyrazinamide include nausea, vomiting, rash, fever, dark-colored urine, sweating, increased sputum production, salivation, watery eyes, peripheral neuropathy (tingling and numbness in the feet and hands), increased liver enzymes, jaundice, elevated uric acid levels in the blood, and visual impairment.

Expert Advice

Rifampicin, Isoniazid, Piperine, Ethambutol, and Pyrazinamide must be taken on an empty stomach at the same time every day.
Do not skip any doses and complete the full course of treatment, even if you feel better.
Stopping the medication early may result in the infection returning and becoming harder to treat.
Discontinue Rifampicin, Isoniazid, Piperine, Ethambutol, and Pyrazinamide and inform your doctor immediately if you experience:

a rash
itchy skin
swelling of the face and mouth
difficulty in breathing

It is advisable to drink plenty of fluids and maintain a healthy diet while taking the medication.
Be aware that it may cause dizziness.
Do not drive or engage in activities that require mental focus until you understand how the medication affects you.