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Erlotinib

Uses

Erlotinib is used in the treatment of non-small cell lung cancer and pancreatic cancer.

How it Works

How Erlotinib works Erlotinib is an anti-cancer medication. Epidermal growth factor receptors (EGFR) are present on the surfaces of lung cancer cells and play a role in regulating their growth. This medication works by binding to the chemical messenger EGFR, thereby inhibiting the cancer signaling pathways mediated by EGFR. This mechanism restricts the further growth of cancer cells.

Side Effects

Common side effects of Erlotinib include acne, conjunctivitis, dry skin, gastrointestinal bleeding, hair follicle inflammation, hair loss, nosebleeds, skin fissures, corneal inflammation, paronychia, and renal insufficiency.

Expert Advice

  • Erlotinib is used to treat non-small cell lung cancer that is locally advanced or has metastasized to other areas of the body.
  • It should be taken 1 hour before or 2 hours after a meal.
  • Diarrhea may occur as a side effect; drink plenty of fluids and inform your doctor if it persists or if you notice blood in your stools.
  • Use a reliable contraceptive method to prevent pregnancy while taking this medicine and for one month after discontinuation.
  • Erlotinib increases skin sensitivity to sunlight; apply sunscreen or wear protective clothing when outdoors.
  • Avoid smoking while on this medication, as it can reduce the drug's effectiveness and may require dose adjustments.
  • Do not take with medications that lower stomach acid (such as antacids or H2 blockers including ranitidine), as this may affect the efficacy of the drug.
  • Inform your doctor if you experience mouth ulceration, changes in vision, or worsening cough, shortness of breath, or breathing difficulties while taking this medication.
  • Your doctor may recommend regular blood tests to monitor liver function during treatment.
  • Do not take this medicine if you are pregnant, planning to conceive, or breastfeeding.

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Frequently asked questions

Erlotinib can cause conjunctivitis and dry eyes. If you experience acute or worsening eye redness, pain, increased watering, blurred vision, or sensitivity to light, contact your doctor immediately for potential urgent treatment.
You should take Erlotinib daily for as long as your doctor prescribes. The treatment duration may vary based on individual circumstances.
Erlotinib should be taken orally once daily on an empty stomach, at least 1 hour before or 2 hours after meals, as prescribed by your doctor. It is advisable to take it at the same time each day for consistency.
Erlotinib is not a traditional chemotherapy drug; it is a kinase inhibitor that blocks abnormal proteins that signal cancer cells to multiply, thereby slowing or stopping the spread of cancer.
Yes, smoking can significantly reduce the effectiveness of Erlotinib. It is recommended to stop smoking before starting treatment, and your doctor may need to adjust your dose if you continue smoking or change your smoking habits.
Avoid pregnancy during Erlotinib treatment. If you are of child-bearing age, use effective contraception during treatment and avoid pregnancy for at least 1 month after your last dose.
A rash is a common side effect of Erlotinib. Do not stop taking the medication; instead, consult your doctor for appropriate treatment. Additionally, minimize sun exposure, use sunscreen, and wear protective clothing.
Contact your doctor if you have sudden breathing difficulties with cough or fever, severe diarrhea, loss of appetite, nausea, or vomiting. Also, inform them of any acute eye issues or if you experience unexplained muscle pain, tenderness, weakness, or cramps while taking a statin.
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