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Ergotamine

Uses

Ergotamine is used in the treatment of acute migraine headaches and Raynaud's disease.

How it Works

How Ergotamine Works Migraine headaches are thought to result from the dilation of blood vessels in the head. Ergotamine is a serotonin receptor antagonist. It works by maintaining the level of serotonin, a chemical messenger, in the brain, thus preventing the transmission of pain. It also inhibits the production of pro-inflammatory neuropeptides, which are responsible for migraine pain. Additionally, it activates 5-HT1D receptors to constrict blood vessels and alleviate pain.

Side Effects

Common side effects of Ergotamine include nausea, vomiting, muscle pain, and leg pain.

Expert Advice

  • Ergotamine is effective in treating an acute migraine attack. Take it as soon as you notice the first signs of a migraine.
  • Some tips that may help avoid a migraine attack include:
    • Have your meals at the same time every day.
    • Avoid bright lights and extreme temperatures.
    • Avoid loud music and noisy places.
    • Avoid chocolates, cheese, processed foods, alcohol, and smoking.
    • Get sufficient sleep and manage stress.
  • Ergotamine should be taken at night before going to bed, as it may cause sleepiness.
  • Do not drive or engage in activities that require mental focus until you understand how Ergotamine affects you.
  • Do not stop taking the medication suddenly, as this can lead to worsening headaches.
  • Ergotamine is also used in the prevention and treatment of migraine headaches.
  • Do not use it to treat an acute migraine attack.

Other Combinations

Caffeine + Ergotamine

Caffeine + Ergotamine + Paracetamol (Acetaminophen) + Prochlorperazine

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Frequently asked questions

Yes, Ergotamine can cause dependence and should not be used regularly or for migraine prevention, as this can lead to rebound headaches and increased usage.
No, Ergotamine should not be used regularly, even at prescribed dosages, as it may lead to ergotism, which can cause decreased blood supply to the brain, resulting in symptoms like limb weakness, blurred vision, and slurred speech.
Take one tablet at the first sign of a migraine. If the headache persists after 30 minutes, you may take an additional half or whole tablet. Continue taking half or one tablet every 30 minutes until the headache resolves, up to a maximum of 3 tablets (6 mg) in 24 hours or 6 tablets (12 mg) in one week. Consult your doctor if the headache continues.
Ergotamine is derived from the Claviceps species, primarily Claviceps purpurea.
Ergotamine is classified as an ergot alkaloid, which works by constricting blood vessels in the head to alleviate headaches.
Overdose symptoms may include vomiting, numbness, tingling, pain, blue extremities, lack of pulse, dizziness, faintness, drowsiness, unconsciousness, and potentially coma or seizures. If vomiting hasn't occurred, the stomach should be cleared.
Serious side effects may include leg weakness, chest pain, irregular heartbeat, dizziness, and muscle pain in limbs. Other symptoms include blue extremities, swelling, itching, and tingling in fingers and toes. Seek immediate medical attention if these occur.
Avoid grapefruit juice, smoking, and alcohol while taking Ergotamine, as they can increase side effects. If drowsy, do not drive or operate heavy machinery. Pregnant or breastfeeding individuals should avoid Ergotamine due to potential harm to the baby.
Avoid taking zolmitriptan, almotriptan, sumatriptan, rizatriptan, or frovatriptan for 24 hours after Ergotamine. Additionally, do not take Ergotamine for 6 hours after these medications. Eletriptan and Ergotamine should not be used within 24 hours of each other.
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