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Edaravone

Uses

Edaravone is used in the treatment of Alzheimer's disease, amyotrophic lateral sclerosis (ALS), stroke, dementia associated with Parkinson's disease, age-related memory loss, and head injuries.

How it Works

How Edaravone works Edaravone is an antioxidant with nootropic (nerve enrichment) and neuroprotective properties. It functions by slowing nerve damage caused by harmful chemicals (free radicals). This action delays the progression of amyotrophic lateral sclerosis (ALS) symptoms by reducing oxidative stress, which is an imbalance between free radicals and antioxidants in the brain.

Side Effects

Common side effects of Edaravone include headache, rash, chest pain, abnormal gait, cough, confusion, dry skin, breathing difficulty, and tachycardia.

Expert Advice

  • Edaravone slows the decline of physical function and helps relieve symptoms of amyotrophic lateral sclerosis (ALS), such as muscle cramps and fatigue.
  • It is administered through a needle into a vein by your healthcare provider.
  • The full dose of Edaravone takes approximately 60 minutes to receive.
  • Wear relaxed, loose-fitting clothing and stay hydrated during treatment with this medication.
  • Inform your doctor if you are pregnant or breastfeeding.
  • Notify your doctor immediately if you experience any of the following after receiving this medication:
    • Itching
    • Swelling of the lips, tongue, or face
    • Breathing problems
    • Trouble swallowing
  • Inform your doctor if you have a known allergy to sulfa drugs.

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Frequently asked questions

Early symptoms of ALS include muscle twitches in the arms, legs, shoulders, or tongue, muscle cramps, stiffness (spasticity), weakness in limbs or neck, slurred or nasal speech, and difficulty chewing or swallowing. Symptoms often begin in the hands or arms, affecting simple tasks, or in the legs, causing awkwardness while walking or increased tripping.
Caucasians and non-Hispanics are more likely to develop ALS, with symptoms typically appearing between ages 55 and 75. The disease is slightly more common in men than women, though this difference diminishes with age. Additionally, military veterans may be 1.5 to 2 times more likely to develop ALS due to toxin exposure.
The most common side effects of Edaravone include confusion, headache, and difficulty walking. Uncommon side effects may include skin allergies (rash and itching), breathing difficulties, chest tightness, wheezing, coughing (especially in individuals with asthma), and fungal infections.
There are currently no studies confirming whether ALS can be prevented. However, awareness of risk factors, such as smoking, exposure to pesticides, and military service, may help reduce the likelihood of developing the disease.
Researchers suggest that exposure to toxins during military service and the physical demands of athletic activity may contribute to the increased risk of ALS among veterans and athletes.
Before taking Edaravone, inform your doctor about any allergies to the medication or its components, as well as any other medications, vitamins, or supplements you are taking. Discuss your medical history, including asthma, pregnancy, or breastfeeding status, as these factors may require monitoring or dosage adjustments.
Edaravone is used to treat amyotrophic lateral sclerosis (ALS) by slowing the nerve damage that leads to the worsening of ALS symptoms, as the condition causes the nerves controlling muscle movement to gradually deteriorate, resulting in muscle shrinkage and weakness.
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