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Denosumab

Uses

Denosumab is used in the treatment of osteoporosis. It is also utilized to treat bone loss in men with prostate cancer and in women with breast cancer who are undergoing specific treatments that increase their risk of fractures.

How it Works

Denosumab is a monoclonal antibody that binds to a protein responsible for bone loss. This action strengthens the bone and reduces the risk of fractures.

Side Effects

Common side effects of Denosumab include rash, musculoskeletal pain (bone, muscle, or joint), eczema, upper respiratory tract infection, sciatica, pain in extremities, back pain, joint pain, urinary tract infection, constipation, abdominal discomfort, hair loss, hypercholesterolemia (high cholesterol), and cystitis.

Expert Advice

  • Denosumab is a medication used to treat thinning of the bones (osteoporosis).
  • Take calcium and vitamin D to help build your bones while using Denosumab.
  • Do not take Denosumab if you are pregnant or planning to become pregnant.
  • May cause a rare jaw problem (osteonecrosis), primarily observed after dental procedures.
  • Inform your doctor if you experience sudden jaw pain.
  • Denosumab may also increase the risk of infection.
  • Avoid close contact with individuals who have cold, flu, or other contagious illnesses.
  • Notify your doctor if you develop a rash while taking Denosumab.

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Frequently asked questions

Yes, hair loss can occur as a side effect of Denosumab, although it does not affect everyone. Consult your doctor if you have concerns about hair loss.
No, Denosumab should not be used during pregnancy. Effective birth control is advised during treatment and for at least 5 months after the last dose if pregnancy is possible.
No, Denosumab is not a chemotherapy drug. It is a monoclonal antibody that targets a specific protein to treat bone loss and osteoporosis, thereby strengthening bones and reducing fracture risk.
Denosumab should be refrigerated at 36°F to 46°F (2°C to 8°C) in its original carton. Avoid exposing it to warm temperatures, and once removed from the refrigerator, it can be kept at room temperature (up to 77°F or 25°C) in the original carton for up to 14 days.
Denosumab is administered as an injection by a healthcare professional, typically once every 6 months. Your doctor may recommend taking calcium and vitamin D supplements alongside the treatment.
Osteonecrosis of the jaw is a rare side effect of Denosumab, characterized by bone damage in the jaw. To minimize risk, maintain good oral hygiene and have regular dental check-ups. Contact your doctor and dentist if you experience symptoms such as loose teeth, discharge, pain, swelling, or non-healing sores, as these may indicate osteonecrosis.
There is no specific optimal duration for Denosumab treatment in osteoporosis. The patient's response and tolerability are monitored through periodic assessments, particularly after 5 years of use, to determine the appropriate duration of treatment.
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