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Denosumab

Uses

Denosumab is used in the treatment of osteoporosis. It is also utilized to treat bone loss in men with prostate cancer and in women with breast cancer who are undergoing specific treatments that increase their risk of fractures.

How it Works

Denosumab is a monoclonal antibody that binds to a protein responsible for bone loss. This action strengthens the bone and reduces the risk of fractures.

Side Effects

Common side effects of Denosumab include rash, musculoskeletal pain (bone, muscle, or joint), eczema, upper respiratory tract infection, sciatica, pain in extremities, back pain, joint pain, urinary tract infection, constipation, abdominal discomfort, hair loss, hypercholesterolemia (high cholesterol), and cystitis.

Expert Advice

Denosumab is a medication used to treat thinning of the bones (osteoporosis).
Take calcium and vitamin D to help build your bones while using Denosumab.
Do not take Denosumab if you are pregnant or planning to become pregnant.
May cause a rare jaw problem (osteonecrosis), primarily observed after dental procedures.
Inform your doctor if you experience sudden jaw pain.
Denosumab may also increase the risk of infection.
Avoid close contact with individuals who have cold, flu, or other contagious illnesses.
Notify your doctor if you develop a rash while taking Denosumab.

Other Combinations

Related Medications

Salt Composition in both

Denosumab 60mg

Nuclasta 60mg Injection

Cadila Healthcare Ltd.

Prefilled syringe of 1 ml

₹18,000

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Ogain 60mg Injection

₹2,100

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Denoci 60 Injection

Prefilled syringe of 1 ml

₹15,000

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Prolia 60mg Solution for Injection 1ml

Dr. Reddy's Laboratories Ltd.

Prefilled syringe of 1 ml

₹19,687.5

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Denorange Injection

Biorange Biologicals Pvt. Ltd.

Prefilled syringe of 1 ml

₹21,000

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Rozel Injection

Intas Pharmaceuticals Ltd.

Prefilled syringe of 1 ml

₹20,000

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Denoci-OP Injection

Prefilled syringe of 1 ml

₹15,000

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Denuril 60mg Injection 1ml

Alkem Laboratories Ltd.

Prefilled syringe of 1 ml

₹8,085.9

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Olimab 60mg Injection

Intas Pharmaceuticals Ltd.

Prefilled syringe of 1 ml

₹14,990

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Denmab 60mg Injection

Emcure Pharmaceuticals Ltd.

₹20,000

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Denub 60mg Injection 1ml

Alkem Laboratories Ltd.

Prefilled syringe of 1 ml

₹8,085.9

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Denu 60mg Injection 1ml

Alkem Laboratories Ltd.

Prefilled syringe of 1 ml

₹8,625

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition

Denosumab 60mg

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Odensomab 60mg Injection

Prefilled syringe of 1 ml

₹19,600

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Denbri Injection

RPG Life Sciences Ltd.

₹23,500

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Esentra 60mg Injection

Intas Pharmaceuticals Ltd.

₹20,000

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Denoclast 60mg Injection 1ml

Zydus Healthcare Ltd.

Prefilled syringe of 1 ml

₹19,687

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Denolite Injection

Bioelite Lifesciences Pvt. Ltd.

Prefilled syringe of 1 ml

₹22,000

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Ogain Prefilled Syringe

₹21,000

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Denaxa 60mg Injection 1s

Abbott Healthcare Pvt. Ltd.

Prefilled syringe of 1 ml

₹15,937.5

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 60mg

Masden 60mg Pfs Injection 1ml

Mastro Biologicals P Ltd

₹23,000

Deninta SC 60mg Injection 1ml

Intas Pharmaceuticals Ltd.

₹8,010.3

MRP ₹14,053.1

Salt Composition in both

Denosumab 120mg

Xgeva Solution for Injection 1s

Dr. Reddy's Laboratories Ltd.

Vial of 1 Solution

₹28,787

Denoci 120mg Injection 1.7ml

₹24,100.3

MRP ₹29,390.6

Salt Composition in both

Denosumab 120mg

Denosurel 120mg Injection 1s

Reliance Lifecare Pvt. Ltd.

₹31,350

Denoci 120mg Injection 1.7ml

₹24,100.3

MRP ₹29,390.6

Salt Composition in both

Denosumab 120mg

Esentra 120 Injection

Intas Pharmaceuticals Ltd.

₹26,400

Denoci 120mg Injection 1.7ml

₹24,100.3

MRP ₹29,390.6

Salt Composition

Denosumab 120mg

Denoci 120mg Injection 1.7ml

₹24,100.3

MRP ₹29,390.6

Frequently asked questions

Can Denosumab lead to hair loss?

Yes, hair loss can occur as a side effect of Denosumab, although it does not affect everyone. Consult your doctor if you have concerns about hair loss.

Is Denosumab safe to use during pregnancy?

No, Denosumab should not be used during pregnancy. Effective birth control is advised during treatment and for at least 5 months after the last dose if pregnancy is possible.

Is Denosumab classified as a chemotherapy drug?

No, Denosumab is not a chemotherapy drug. It is a monoclonal antibody that targets a specific protein to treat bone loss and osteoporosis, thereby strengthening bones and reducing fracture risk.

What are the storage requirements for Denosumab?

Denosumab should be refrigerated at 36°F to 46°F (2°C to 8°C) in its original carton. Avoid exposing it to warm temperatures, and once removed from the refrigerator, it can be kept at room temperature (up to 77°F or 25°C) in the original carton for up to 14 days.

What is the administration schedule for Denosumab?

Denosumab is administered as an injection by a healthcare professional, typically once every 6 months. Your doctor may recommend taking calcium and vitamin D supplements alongside the treatment.

Does Denosumab increase the risk of osteonecrosis of the jaw?

Osteonecrosis of the jaw is a rare side effect of Denosumab, characterized by bone damage in the jaw. To minimize risk, maintain good oral hygiene and have regular dental check-ups. Contact your doctor and dentist if you experience symptoms such as loose teeth, discharge, pain, swelling, or non-healing sores, as these may indicate osteonecrosis.

What is the recommended duration of Denosumab treatment for osteoporosis?

There is no specific optimal duration for Denosumab treatment in osteoporosis. The patient's response and tolerability are monitored through periodic assessments, particularly after 5 years of use, to determine the appropriate duration of treatment.

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